Mechanism of Action
Controlled ageing transforms the bulb's sulfur profile. The Maillard reaction, which creates its dark colour, accompanies this change. It favours a group of more stable compounds, including S-allyl-cysteine, known as SAC. This marker helps compare and standardise extracts.
After ingestion, the body absorbs and transforms several organosulfur compounds. A human study identified thirty-three compounds and their metabolites in urine after one serving of whole black garlic. This finding documents human exposure to molecules released from the matrix.
Clinical trials also assess vascular tone, blood pressure, lipid transport and endothelial function. These measures structure the study of black garlic in cardiovascular research.
Key Benefits
- Emerging
Home blood pressure: the 250 mg daily Abg10+/Garlace trial reports a favourable change after twelve weeks in adults treated for grade I hypertension.
- Emerging
Diastolic pressure: a crossover trial of 250 mg of an extract standardised to 1.25 mg of S-allyl-cysteine reports a reduction after six weeks in adults with moderate hypercholesterolaemia.
Dosage & Forms
Black garlic is measured in two ways that are not comparable: in milligrams of extract, or in milligrams of S-allyl-cysteine, the organosulfur compound used as the standardisation marker. The second is what makes two preparations comparable.
Controlled aged garlic trials reporting a change in blood pressure use between 1.2 and 2.4 mg of S-allyl-cysteine a day. The extracts are standardised very differently: 250 mg of one supplies 0.25 mg, 250 mg of another supplies 1.25 mg.
Singular delivers 1,200 mg of Abg10+/Garlace extract, which is 1.2 mg of S-allyl-cysteine and the equivalent of 6 g of black garlic. Calibration then follows the individual profile and the formula's safety rules.
In the Singular Formula
Inclusion rationale
Black garlic comes from the same bulb as the garlic used in cooking, after ageing. That ageing removes the pungent compound of raw garlic. In adults being followed for raised blood pressure, a controlled trial records a favourable change in readings taken at home. That result, measured on the aged bulb itself, earns its place in the formula.
Selected form
Abg10+® (Garlace®) is an aqueous extract of aged black garlic bulbs (Allium sativum L.). The process combines controlled temperature and humidity, followed by water extraction. It is an ageing process involving the Maillard reaction, without microbial fermentation. The extract is standardised through an organosulfur compound profile that includes S-allyl-cysteine (SAC). It is also the material evaluated in the controlled trial conducted in adults with hypertension. The selected material uses maltodextrin as a carrier. It retains a characteristic aroma and taste, with less pungency than fresh garlic.
Composition and Origin
Origin : Plant (black garlic (Allium sativum), on maltodextrin).
Allergens contained : Sulphur dioxide and sulphites.
Allergens as traces : None.
Allergens above are declared under European Union regulations. The label of the delivered product carries the declaration applicable to your country of delivery.
Formula dosage
0 to 1,200 mg.
Dose expressed as pure active substance, excluding excipients and carriers of the raw material.
Synergies in the formula
Safety & Precautions
Aged garlic trials, running from six weeks to one year, report reassuring tolerance at the amounts studied. Digestive discomfort or reflux may occur.
People sensitive to sulphites should abstain.
The Singular formula sets black garlic aside where an anticoagulant, an antiplatelet agent or a clotting disorder is declared in the health profile. Professional advice remains recommended with a medicine containing saquinavir. Use is not recommended during the seven days before surgery.
During pregnancy and breastfeeding, black garlic supplementation is not recommended: human data are insufficient and the European authority advises avoiding this use as a precaution.
Scientific Studies
| Authors | Year | Type | Journal | |
|---|---|---|---|---|
| Serrano JCE et al. | 2023 | Randomised Controlled Trial | Nutrients | View on PubMed |
Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial In adults treated for grade I hypertension, 250 mg daily of Abg10+/Garlace favoured home blood pressure measurements over twelve weeks; office blood pressure did not differ between the groups. | ||||
| Valls RM et al. | 2022 | Randomised Controlled Trial | Nutrients | View on PubMed |
Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustained and Controlled Study This crossover trial reports lower diastolic pressure after six weeks with 250 mg daily of an extract standardised to 1.25 mg of SAC. Its primary outcome, LDL cholesterol, did not change, nor did systolic pressure; the trial run on Singular's exact material does not reproduce this effect on office-measured pressure. | ||||
| Ried K et al. | 2013 | Randomised Controlled Trial | European Journal of Clinical Nutrition | View on PubMed |
Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial This dose-response trial of aged garlic compares 0.6, 1.2 and 2.4 mg of S-allyl-cysteine daily for twelve weeks: only the 1.2 mg arm significantly lowered systolic pressure. | ||||
| Jung ES et al. | 2014 | Randomised Controlled Trial | Nutrition | View on PubMed |
Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial This randomised trial reports higher HDL versus placebo after twelve weeks with 6 g daily of black garlic; the fall in ApoB is reported within the treated group. | ||||
| Villaño D et al. | 2023 | Clinical Trial | Nutrients | View on PubMed |
Effect of Black Garlic Consumption on Endothelial Function and Lipid Profile: A Before-and-After Study in Hypercholesterolemic and Non-Hypercholesterolemic Subjects This before-and-after study reports favourable changes in ApoA1 and several endothelial markers after twelve weeks with 12 g daily of whole black garlic. | ||||
| Moreno-Ortega A et al. | 2023 | Clinical Trial | Antioxidants (Basel) | View on PubMed |
Bioavailability of Organosulfur Compounds after the Ingestion of Black Garlic by Healthy Humans After one 20 g serving of whole black garlic, the analysis identified thirty-three organosulfur compounds and urinary metabolites in twelve healthy adults. | ||||