Our bioactives library
Each bioactive is selected for its proven efficacy and optimal bioavailability.
Akkermansia muciniphila
Microbiome & barrierTyndallized Akkermansia muciniphila concentrated at 100 billion cells per gram. Tyndallization is a gentle heat-inactivation process: bacterial cells are heated to 65-70°C in a controlled cycle, inactivating them without denaturing their structural proteins. Unlike a live bacterium, a tyndallized cell requires neither cold chain nor gastro-resistant coating. The decisive advantage lies in the thermostability of the Amuc_1100 protein, located on Akkermansia's outer membrane: this structural protein survives tyndallization and retains its full capacity to interact with intestinal mucosal receptors. The tyndallized form thus delivers the functional active ingredient with a manufacturing stability that the live form cannot guarantee. Quality: vegan.
Akkermansia muciniphila is an anaerobic bacterium that colonises the colonic mucus layer. Its abundance in the human microbiome declines progressively with age — and analyses spanning multiple independent centenarian cohorts consistently identify Akkermansia among the most enriched microbiota signatures in individuals with exceptional longevity. The central mechanism involves the Amuc_1100 protein on its outer membrane, which interacts with intestinal epithelial cell receptors and reinforces the tight junctions controlling mucosal permeability. A less permeable mucosa reduces the passage of bacterial fragments into the general circulation, limiting the chronic low-grade systemic inflammation associated with aging. A randomised controlled trial published in Nature Medicine (2019), conducted in 32 overweight adults over 12 weeks, documented a +28.6% improvement in insulin sensitivity, a 34% reduction in insulinemia and an 8.7% decrease in total cholesterol versus placebo. The tyndallized form was selected because Amuc_1100 is thermostable and retains its activity after cellular inactivation, eliminating the viability constraints of the live form. The synergy with Bifidobacterium longum, Bacillus subtilis, GOS, zinc and vitamin D3 in the formula aims to support the entire mucosal ecosystem: GOS nourish the commensal flora, zinc consolidates tight junctions and vitamin D3 supports the immune component of the mucosa.
0 to 100 mg
Tap to closeAkkermansia muciniphila
Microbiome & barrierTyndallized Akkermansia muciniphila concentrated at 100 billion cells per gram. Tyndallization is a gentle heat-inactivation process: bacterial cells are heated to 65-70°C in a controlled cycle, inactivating them without denaturing their structural proteins. Unlike a live bacterium, a tyndallized cell requires neither cold chain nor gastro-resistant coating. The decisive advantage lies in the thermostability of the Amuc_1100 protein, located on Akkermansia's outer membrane: this structural protein survives tyndallization and retains its full capacity to interact with intestinal mucosal receptors. The tyndallized form thus delivers the functional active ingredient with a manufacturing stability that the live form cannot guarantee. Quality: vegan.
Akkermansia muciniphila is an anaerobic bacterium that colonises the colonic mucus layer. Its abundance in the human microbiome declines progressively with age — and analyses spanning multiple independent centenarian cohorts consistently identify Akkermansia among the most enriched microbiota signatures in individuals with exceptional longevity. The central mechanism involves the Amuc_1100 protein on its outer membrane, which interacts with intestinal epithelial cell receptors and reinforces the tight junctions controlling mucosal permeability. A less permeable mucosa reduces the passage of bacterial fragments into the general circulation, limiting the chronic low-grade systemic inflammation associated with aging. A randomised controlled trial published in Nature Medicine (2019), conducted in 32 overweight adults over 12 weeks, documented a +28.6% improvement in insulin sensitivity, a 34% reduction in insulinemia and an 8.7% decrease in total cholesterol versus placebo. The tyndallized form was selected because Amuc_1100 is thermostable and retains its activity after cellular inactivation, eliminating the viability constraints of the live form. The synergy with Bifidobacterium longum, Bacillus subtilis, GOS, zinc and vitamin D3 in the formula aims to support the entire mucosal ecosystem: GOS nourish the commensal flora, zinc consolidates tight junctions and vitamin D3 supports the immune component of the mucosa.
0 to 100 mg
Astaxanthin
Oxidative stressRed carotenoid pigment extracted from Haematococcus pluvialis microalgae, one of the most concentrated natural sources of astaxanthin. This encapsulated form is water-dispersible, solving the major limitation of natural astaxanthin: its fat-solubility, which restricts intestinal absorption. Encapsulation in a starch and dextrin matrix enables homogeneous dispersion in aqueous media and facilitates assimilation. Unlike synthetic astaxanthin derived from petrochemistry, this form comes from controlled microalgal cultivation. The all-trans isomer, the biologically active form, is guaranteed. Quality: non-GMO, pesticide-free.
Carotenoid of the xanthophyll family, astaxanthin is the pigment responsible for the red color of salmon, shrimp and flamingos. Extracted from the microalga Haematococcus pluvialis, its unique molecular structure allows it to span the lipid bilayer of cell membranes from end to end, a property shared by neither beta-carotene nor vitamin E. This transmembrane position protects membrane integrity both at the surface and deep within. Cell membranes become fragile with age under cumulative oxidative stress. Randomized clinical trials have shown that supplementation of 4 to 12 mg/day for 8 to 12 weeks reduces plasma markers of lipid peroxidation (MDA, isoprostanes). A meta-analysis of 14 controlled trials involving over 600 participants confirmed a significant reduction in circulating MDA. Unlike other carotenoids, astaxanthin does not convert to vitamin A, eliminating any risk of hypervitaminosis A even at high doses. In the formula, it complements lutein and zeaxanthin (also present) to form a trio of carotenoids with complementary localizations: astaxanthin in cell membranes, lutein at the periphery of the macula, zeaxanthin at the center of the macular pigment.
0 to 8 mg
Tap to closeAstaxanthin
Oxidative stressRed carotenoid pigment extracted from Haematococcus pluvialis microalgae, one of the most concentrated natural sources of astaxanthin. This encapsulated form is water-dispersible, solving the major limitation of natural astaxanthin: its fat-solubility, which restricts intestinal absorption. Encapsulation in a starch and dextrin matrix enables homogeneous dispersion in aqueous media and facilitates assimilation. Unlike synthetic astaxanthin derived from petrochemistry, this form comes from controlled microalgal cultivation. The all-trans isomer, the biologically active form, is guaranteed. Quality: non-GMO, pesticide-free.
Carotenoid of the xanthophyll family, astaxanthin is the pigment responsible for the red color of salmon, shrimp and flamingos. Extracted from the microalga Haematococcus pluvialis, its unique molecular structure allows it to span the lipid bilayer of cell membranes from end to end, a property shared by neither beta-carotene nor vitamin E. This transmembrane position protects membrane integrity both at the surface and deep within. Cell membranes become fragile with age under cumulative oxidative stress. Randomized clinical trials have shown that supplementation of 4 to 12 mg/day for 8 to 12 weeks reduces plasma markers of lipid peroxidation (MDA, isoprostanes). A meta-analysis of 14 controlled trials involving over 600 participants confirmed a significant reduction in circulating MDA. Unlike other carotenoids, astaxanthin does not convert to vitamin A, eliminating any risk of hypervitaminosis A even at high doses. In the formula, it complements lutein and zeaxanthin (also present) to form a trio of carotenoids with complementary localizations: astaxanthin in cell membranes, lutein at the periphery of the macula, zeaxanthin at the center of the macular pigment.
0 to 8 mg
Bacillus subtilis
Microbiome & barrierSporebiotic Bacillus subtilis strain concentrated at 100 billion CFU per gram. Unlike conventional probiotics (Lactobacillus, Bifidobacterium), Bacillus subtilis forms spores: natural resistance structures that protect the bacterium from gastric acidity and bile, with no need for coating or refrigeration. The survival rate through to the intestine is therefore significantly higher than that of non-spore-forming vegetative forms. Spores germinate once the intestinal environment is reached. Quality: vegan, non-GMO.
Gram-positive spore-forming bacterium whose spore form resists gastric acidity, bile salts and temperature variations. This resistance allows it to reach the intestinal tract intact, where conventional probiotics in vegetative form lose a significant portion of their viability. Naturally present in soils and the human gastrointestinal tract, Bacillus subtilis has been used in human nutrition for decades, particularly in Japan in the fermentation of natto (fermented soy consumed daily for centuries). Once in the intestine, the spores germinate and resume their metabolic activity, contributing to the microbial diversity of the resident microbiota. The stability of the spore form is a decisive advantage for a powder formula stored at room temperature: no cold chain is required, and viability is preserved throughout the product's shelf life. In the formula, Bacillus subtilis integrates into a complete microbial ecosystem alongside tyndallised Bifidobacterium longum and tyndallised Akkermansia muciniphila (resident postbiotics), as well as GOS (prebiotic galacto-oligosaccharides that selectively feed bifidobacteria). This approach combining spore-forming probiotics, resident postbiotics and selective prebiotics aims to support the diversity of the intestinal microbiota, whose decline is a recognised marker of biological ageing.
0 to 9 mg
Tap to closeBacillus subtilis
Microbiome & barrierSporebiotic Bacillus subtilis strain concentrated at 100 billion CFU per gram. Unlike conventional probiotics (Lactobacillus, Bifidobacterium), Bacillus subtilis forms spores: natural resistance structures that protect the bacterium from gastric acidity and bile, with no need for coating or refrigeration. The survival rate through to the intestine is therefore significantly higher than that of non-spore-forming vegetative forms. Spores germinate once the intestinal environment is reached. Quality: vegan, non-GMO.
Gram-positive spore-forming bacterium whose spore form resists gastric acidity, bile salts and temperature variations. This resistance allows it to reach the intestinal tract intact, where conventional probiotics in vegetative form lose a significant portion of their viability. Naturally present in soils and the human gastrointestinal tract, Bacillus subtilis has been used in human nutrition for decades, particularly in Japan in the fermentation of natto (fermented soy consumed daily for centuries). Once in the intestine, the spores germinate and resume their metabolic activity, contributing to the microbial diversity of the resident microbiota. The stability of the spore form is a decisive advantage for a powder formula stored at room temperature: no cold chain is required, and viability is preserved throughout the product's shelf life. In the formula, Bacillus subtilis integrates into a complete microbial ecosystem alongside tyndallised Bifidobacterium longum and tyndallised Akkermansia muciniphila (resident postbiotics), as well as GOS (prebiotic galacto-oligosaccharides that selectively feed bifidobacteria). This approach combining spore-forming probiotics, resident postbiotics and selective prebiotics aims to support the diversity of the intestinal microbiota, whose decline is a recognised marker of biological ageing.
0 to 9 mg
Berberine
Cellular metabolismPlant alkaloid extracted from barberry root (Berberis vulgaris), through hydroethanolic extraction with a concentrated ratio of approximately 50:1. This highly purified form as berberine hydrochloride is obtained without preservatives or residual solvents. Extraction from the root, the part richest in berberine, ensures an optimal alkaloid profile. Quality: vegan, non-GMO, pesticide-free, allergen-free, preservative-free, residual solvent-free, Halal and Kosher certified.
Isoquinoline alkaloid with an intense yellow pigment, naturally found in barberry (Berberis vulgaris), goldenseal and coptis. Used for millennia in Chinese and Ayurvedic herbal traditions, berberine is today one of the most studied plant compounds in the world, with over 5,000 referenced scientific publications. Its primary mechanism rests on the regulation of cellular energy metabolism. Berberine modulates glycemic balance by acting on pathways that govern how cells use glucose and lipids. Meta-analyses of randomized controlled trials have demonstrated a significant reduction in fasting blood glucose and glycated hemoglobin in participants with disrupted carbohydrate metabolism, with magnitudes comparable to certain reference molecules. Research also documents reductions in total cholesterol and triglycerides in several controlled trials. Its naturally limited oral bioavailability (less than 5% in free form) has led to the development of optimized forms. Extracts standardized in berberine hydrochloride, combined with enhanced absorption technologies, achieve relevant plasma concentrations. The safety profile is well documented at supplementation doses, with a track record of human use spanning several decades.
0 to 380 mg
Tap to closeBerberine
Cellular metabolismPlant alkaloid extracted from barberry root (Berberis vulgaris), through hydroethanolic extraction with a concentrated ratio of approximately 50:1. This highly purified form as berberine hydrochloride is obtained without preservatives or residual solvents. Extraction from the root, the part richest in berberine, ensures an optimal alkaloid profile. Quality: vegan, non-GMO, pesticide-free, allergen-free, preservative-free, residual solvent-free, Halal and Kosher certified.
Isoquinoline alkaloid with an intense yellow pigment, naturally found in barberry (Berberis vulgaris), goldenseal and coptis. Used for millennia in Chinese and Ayurvedic herbal traditions, berberine is today one of the most studied plant compounds in the world, with over 5,000 referenced scientific publications. Its primary mechanism rests on the regulation of cellular energy metabolism. Berberine modulates glycemic balance by acting on pathways that govern how cells use glucose and lipids. Meta-analyses of randomized controlled trials have demonstrated a significant reduction in fasting blood glucose and glycated hemoglobin in participants with disrupted carbohydrate metabolism, with magnitudes comparable to certain reference molecules. Research also documents reductions in total cholesterol and triglycerides in several controlled trials. Its naturally limited oral bioavailability (less than 5% in free form) has led to the development of optimized forms. Extracts standardized in berberine hydrochloride, combined with enhanced absorption technologies, achieve relevant plasma concentrations. The safety profile is well documented at supplementation doses, with a track record of human use spanning several decades.
0 to 380 mg
Bifidobacterium longum
Microbiome & barrierBifidobacterium longum in tyndallised form (postbiotic), concentrated at 100 billion equivalent cells per gram. Tyndallisation is a controlled heat treatment that inactivates bacterial cells while fully preserving their structural components — cell wall, peptidoglycan, lipoteichoic acid. These components retain their capacity to interact with immune receptors in the intestinal mucosa. Unlike a live probiotic that requires refrigeration to maintain viability, this postbiotic is stable at room temperature and requires no cold chain. This superior stability ensures consistent biological activity throughout its shelf life. Quality: vegan, non-GMO.
Bifidobacterium longum is the bifidobacterium most closely associated with human longevity. Among bacterial genera, bifidobacteria colonise the intestine from birth and their proportion progressively declines with age — a phenomenon correlated with the decline of mucosal immunity and increased low-grade inflammation. Analyses spanning multiple independent centenarian cohorts from different world regions consistently identify B. longum among the most consistent microbial signatures in individuals who have surpassed 100 years. A recent systematic review (Food Science and Biotechnology, 2024) designates B. longum as the flagship strain of this association and analyses potential mechanisms: mucosal immunomodulation, gut-brain axis, inflammaging reduction. The tyndallised (postbiotic) form is not a degraded probiotic: tyndallisation preserves the active bacterial structures — peptidoglycan and lipoteichoic acid — that stimulate immune receptors in the mucosa without colonisation. A double-blind randomised controlled trial (n=200, 12 weeks) demonstrated significant efficacy of the tyndallised HT-ES1 form on digestive symptoms versus placebo. A pilot trial in healthy adults confirmed impact on microbiota composition, with an increase in butyrate-producing bacteria and a reduction in non-HDL cholesterol. In the formula, tyndallised B. longum acts synergistically with GOS (prebiotic fibres that selectively nourish endogenous bifidobacteria), Bacillus subtilis with complementary mechanisms, and Akkermansia muciniphila, specialist in mucosal barrier reinforcement.
0 to 100 mg
Tap to closeBifidobacterium longum
Microbiome & barrierBifidobacterium longum in tyndallised form (postbiotic), concentrated at 100 billion equivalent cells per gram. Tyndallisation is a controlled heat treatment that inactivates bacterial cells while fully preserving their structural components — cell wall, peptidoglycan, lipoteichoic acid. These components retain their capacity to interact with immune receptors in the intestinal mucosa. Unlike a live probiotic that requires refrigeration to maintain viability, this postbiotic is stable at room temperature and requires no cold chain. This superior stability ensures consistent biological activity throughout its shelf life. Quality: vegan, non-GMO.
Bifidobacterium longum is the bifidobacterium most closely associated with human longevity. Among bacterial genera, bifidobacteria colonise the intestine from birth and their proportion progressively declines with age — a phenomenon correlated with the decline of mucosal immunity and increased low-grade inflammation. Analyses spanning multiple independent centenarian cohorts from different world regions consistently identify B. longum among the most consistent microbial signatures in individuals who have surpassed 100 years. A recent systematic review (Food Science and Biotechnology, 2024) designates B. longum as the flagship strain of this association and analyses potential mechanisms: mucosal immunomodulation, gut-brain axis, inflammaging reduction. The tyndallised (postbiotic) form is not a degraded probiotic: tyndallisation preserves the active bacterial structures — peptidoglycan and lipoteichoic acid — that stimulate immune receptors in the mucosa without colonisation. A double-blind randomised controlled trial (n=200, 12 weeks) demonstrated significant efficacy of the tyndallised HT-ES1 form on digestive symptoms versus placebo. A pilot trial in healthy adults confirmed impact on microbiota composition, with an increase in butyrate-producing bacteria and a reduction in non-HDL cholesterol. In the formula, tyndallised B. longum acts synergistically with GOS (prebiotic fibres that selectively nourish endogenous bifidobacteria), Bacillus subtilis with complementary mechanisms, and Akkermansia muciniphila, specialist in mucosal barrier reinforcement.
0 to 100 mg
Black Garlic
Systemic inflammationBlack garlic bulb extract (Allium sativum L.), standardised for S-allyl-cysteine (SAC), a stable sulphur compound resulting from the controlled fermentation of white garlic. The fermentation process at controlled temperature and humidity over several weeks converts the unstable sulphur compounds of raw garlic (allicin) into SAC, a stable and highly bioavailable form. The extraction ratio of approximately 10:1 concentrates the compounds of interest. Unlike raw garlic or conventional garlic extracts, SAC from black garlic does not generate a strong sulphurous odour. Quality: non-GMO, pesticide-free.
White garlic transformed through a slow maturation process at controlled temperature and humidity over several weeks. This transformation, known as the Maillard reaction, produces the melanoidins that give black garlic its characteristic color and umami taste, while concentrating S-allyl-cysteine (SAC), a stable and highly bioavailable organosulfur compound. SAC is the most studied bioactive compound in black garlic. Unlike allicin from fresh garlic, which is unstable and rapidly degraded in the digestive tract, SAC resists digestion and reaches the bloodstream with an estimated bioavailability of nearly 98%. Randomized clinical trials have evaluated black garlic on cardiovascular health markers: reduction in arterial stiffness, improvement in lipid profile and modulation of LDL oxidation markers. The organosulfur compounds in garlic contribute to the normal functioning of the cardiovascular system. The Maillard process that transforms white garlic into black garlic also eliminates the digestive discomforts and characteristic odor of raw garlic, considerably improving daily adherence. The melanoidins formed during this transformation possess documented antioxidant properties of their own, adding a complementary benefit to SAC. From a longevity perspective, maintaining vascular health is one of the pillars of preserving organ function with age.
0 to 1,000 mg
Tap to closeBlack Garlic
Systemic inflammationBlack garlic bulb extract (Allium sativum L.), standardised for S-allyl-cysteine (SAC), a stable sulphur compound resulting from the controlled fermentation of white garlic. The fermentation process at controlled temperature and humidity over several weeks converts the unstable sulphur compounds of raw garlic (allicin) into SAC, a stable and highly bioavailable form. The extraction ratio of approximately 10:1 concentrates the compounds of interest. Unlike raw garlic or conventional garlic extracts, SAC from black garlic does not generate a strong sulphurous odour. Quality: non-GMO, pesticide-free.
White garlic transformed through a slow maturation process at controlled temperature and humidity over several weeks. This transformation, known as the Maillard reaction, produces the melanoidins that give black garlic its characteristic color and umami taste, while concentrating S-allyl-cysteine (SAC), a stable and highly bioavailable organosulfur compound. SAC is the most studied bioactive compound in black garlic. Unlike allicin from fresh garlic, which is unstable and rapidly degraded in the digestive tract, SAC resists digestion and reaches the bloodstream with an estimated bioavailability of nearly 98%. Randomized clinical trials have evaluated black garlic on cardiovascular health markers: reduction in arterial stiffness, improvement in lipid profile and modulation of LDL oxidation markers. The organosulfur compounds in garlic contribute to the normal functioning of the cardiovascular system. The Maillard process that transforms white garlic into black garlic also eliminates the digestive discomforts and characteristic odor of raw garlic, considerably improving daily adherence. The melanoidins formed during this transformation possess documented antioxidant properties of their own, adding a complementary benefit to SAC. From a longevity perspective, maintaining vascular health is one of the pillars of preserving organ function with age.
0 to 1,000 mg
Boron
Tissue structureBoron as sodium tetraborate decahydrate (borax). This mineral form provides approximately 11% elemental boron, one of the highest concentrations among authorised food sources. Boron is a trace element naturally present in fruits, vegetables and nuts. The decahydrate form ensures a progressive release of boron in the body. Pure raw material. Quality: non-GMO, no excipient.
Trace element found in significant concentrations in fruits (apples, grapes), legumes and nuts. Boron is naturally present in human bone and dental tissues, where it actively participates in mineral metabolism. Research over the past two decades has revealed boron's involvement in the metabolism of calcium, magnesium and vitamin D, three nutrients essential to bone health. Boron influences the activity of osteoblasts (cells that build bone) and modulates the body's use of calcium and magnesium. It also plays a role in the metabolism of steroid hormones, whose levels decline with age. In the formula, boron is part of a complete bone axis alongside vitamin D3, vitamin K2 MK-7, magnesium and calcium alpha-ketoglutarate (all present in the formula). Vitamin D3 promotes intestinal calcium absorption, vitamin K2 directs calcium toward bones rather than arteries, magnesium is a cofactor in bone mineralization, and boron optimizes the utilization of the whole. Modern diets, low in fresh fruits and vegetables, may not provide optimal boron intakes, making targeted supplementation relevant.
0 to 3 mg
Tap to closeBoron
Tissue structureBoron as sodium tetraborate decahydrate (borax). This mineral form provides approximately 11% elemental boron, one of the highest concentrations among authorised food sources. Boron is a trace element naturally present in fruits, vegetables and nuts. The decahydrate form ensures a progressive release of boron in the body. Pure raw material. Quality: non-GMO, no excipient.
Trace element found in significant concentrations in fruits (apples, grapes), legumes and nuts. Boron is naturally present in human bone and dental tissues, where it actively participates in mineral metabolism. Research over the past two decades has revealed boron's involvement in the metabolism of calcium, magnesium and vitamin D, three nutrients essential to bone health. Boron influences the activity of osteoblasts (cells that build bone) and modulates the body's use of calcium and magnesium. It also plays a role in the metabolism of steroid hormones, whose levels decline with age. In the formula, boron is part of a complete bone axis alongside vitamin D3, vitamin K2 MK-7, magnesium and calcium alpha-ketoglutarate (all present in the formula). Vitamin D3 promotes intestinal calcium absorption, vitamin K2 directs calcium toward bones rather than arteries, magnesium is a cofactor in bone mineralization, and boron optimizes the utilization of the whole. Modern diets, low in fresh fruits and vegetables, may not provide optimal boron intakes, making targeted supplementation relevant.
0 to 3 mg
Ca-AKG
Mitochondrial energyCalcium salt of alpha-ketoglutaric acid (AKG), a key intermediate in the Krebs cycle, the primary pathway for cellular energy production. The calcium form simultaneously provides elemental calcium (approximately 19.5%) and AKG in a single compound, with no added excipient. Unlike free forms of AKG, calcium chelation stabilises the molecule and improves digestive tolerance. AKG naturally participates in amino acid metabolism and energy production within the mitochondria. Quality: non-GMO, no excipient.
Calcium salt of alpha-ketoglutarate, a central intermediate of the Krebs cycle (the primary energy production pathway in every cell). In this calcium-bound form, it offers oral bioavailability suited to supplementation and a dual nutritional benefit: supporting intermediary energy metabolism while contributing to calcium needs, essential for the maintenance of normal bones and teeth. Alpha-ketoglutarate is an endogenous metabolite whose plasma concentrations naturally decline with age, a decline that coincides with the progressive weakening of cellular energy metabolism. This decline has sparked growing interest in aging research. A study published in 2020 observed in CaAKG-supplemented mice a compression of morbidity and a reduction in biological age assessed by epigenetic clock. These preliminary animal results have paved the way for ongoing human clinical trials. Beyond its metabolic role, the calcium provided by this form integrates into the formula's bone axis alongside vitamin D3, vitamin K2 MK-7, magnesium and boron (all present in the formula). Calcium contributes to the maintenance of normal bones, and its combination with vitamin D and vitamin K2 optimizes its utilization by bone tissue.
0 to 1 g
Tap to closeCa-AKG
Mitochondrial energyCalcium salt of alpha-ketoglutaric acid (AKG), a key intermediate in the Krebs cycle, the primary pathway for cellular energy production. The calcium form simultaneously provides elemental calcium (approximately 19.5%) and AKG in a single compound, with no added excipient. Unlike free forms of AKG, calcium chelation stabilises the molecule and improves digestive tolerance. AKG naturally participates in amino acid metabolism and energy production within the mitochondria. Quality: non-GMO, no excipient.
Calcium salt of alpha-ketoglutarate, a central intermediate of the Krebs cycle (the primary energy production pathway in every cell). In this calcium-bound form, it offers oral bioavailability suited to supplementation and a dual nutritional benefit: supporting intermediary energy metabolism while contributing to calcium needs, essential for the maintenance of normal bones and teeth. Alpha-ketoglutarate is an endogenous metabolite whose plasma concentrations naturally decline with age, a decline that coincides with the progressive weakening of cellular energy metabolism. This decline has sparked growing interest in aging research. A study published in 2020 observed in CaAKG-supplemented mice a compression of morbidity and a reduction in biological age assessed by epigenetic clock. These preliminary animal results have paved the way for ongoing human clinical trials. Beyond its metabolic role, the calcium provided by this form integrates into the formula's bone axis alongside vitamin D3, vitamin K2 MK-7, magnesium and boron (all present in the formula). Calcium contributes to the maintenance of normal bones, and its combination with vitamin D and vitamin K2 optimizes its utilization by bone tissue.
0 to 1 g
Collagen Type II
Tissue structureNon-denatured type II collagen (NUVICOL II), extracted from chicken sternum cartilage, manufactured in the Netherlands. The non-denatured form preserves the native three-dimensional structure of collagen, which is essential: denatured (hydrolysed) type II collagen loses its conformation and specific epitopes. This natural cartilage matrix also contains chondroitin sulphate and hydroxyproline, structural components of hyaline cartilage. Type II collagen is the predominant protein in articular cartilage. Single chicken source. Quality: no excipient.
Type II collagen in undenatured native form. Type II collagen is the main structural component of hyaline cartilage, which covers joint surfaces and provides mechanical cushioning between bones. The undenatured form preserves the original three-dimensional structure of the protein, fundamentally distinguishing it from hydrolyzed forms. This distinction is essential because the mechanism of action of undenatured type II collagen does not rely on amino acid supply but on immune recognition. By retaining its intact antigenic epitopes, it interacts with the Peyer's patches of the small intestine through a process called oral tolerance. This natural immune mechanism modulates the immune system's response toward endogenous joint collagen, contributing to joint comfort. Effective doses are very low (40 mg/day), precisely because the effect relies on an immune signal rather than a massive protein supply. Randomized clinical trials have compared undenatured type II collagen to glucosamine with chondroitin, showing favorable results on joint comfort scores. In the formula, type II collagen works in complementarity with glucosamine (also present), which takes a different pathway by providing the direct precursors of cartilage glycosaminoglycans. Two complementary mechanisms for a single objective.
0 to 50 mg
Tap to closeCollagen Type II
Tissue structureNon-denatured type II collagen (NUVICOL II), extracted from chicken sternum cartilage, manufactured in the Netherlands. The non-denatured form preserves the native three-dimensional structure of collagen, which is essential: denatured (hydrolysed) type II collagen loses its conformation and specific epitopes. This natural cartilage matrix also contains chondroitin sulphate and hydroxyproline, structural components of hyaline cartilage. Type II collagen is the predominant protein in articular cartilage. Single chicken source. Quality: no excipient.
Type II collagen in undenatured native form. Type II collagen is the main structural component of hyaline cartilage, which covers joint surfaces and provides mechanical cushioning between bones. The undenatured form preserves the original three-dimensional structure of the protein, fundamentally distinguishing it from hydrolyzed forms. This distinction is essential because the mechanism of action of undenatured type II collagen does not rely on amino acid supply but on immune recognition. By retaining its intact antigenic epitopes, it interacts with the Peyer's patches of the small intestine through a process called oral tolerance. This natural immune mechanism modulates the immune system's response toward endogenous joint collagen, contributing to joint comfort. Effective doses are very low (40 mg/day), precisely because the effect relies on an immune signal rather than a massive protein supply. Randomized clinical trials have compared undenatured type II collagen to glucosamine with chondroitin, showing favorable results on joint comfort scores. In the formula, type II collagen works in complementarity with glucosamine (also present), which takes a different pathway by providing the direct precursors of cartilage glycosaminoglycans. Two complementary mechanisms for a single objective.
0 to 50 mg
Collagen Types I and III
Tissue structureHydrolysed bovine collagen peptides, types I and III, sourced from bovine skin. Enzymatic hydrolysis reduces the molecular weight to 1,000-5,000 daltons, enabling cold-water solubility and facilitating intestinal absorption compared to non-hydrolysed native collagen. This matrix provides the amino acids specific to collagen (glycine, proline, hydroxyproline), which are scarce in other dietary protein sources. Manufactured in Europe (Italy/Netherlands). No additives, no major allergens (other than bovine origin). Halal and Kosher certified. Quality: Halal and Kosher certified.
Type I collagen in the form of hydrolyzed peptides. Type I collagen is the most abundant structural protein in the human body, constituting approximately 90% of total collagen, found in skin, bones, tendons and ligaments. Its endogenous production decreases by approximately 1 to 1.5% per year from age 25, a process accelerated by UV exposure, smoking and oxidative stress. Enzymatic hydrolysis produces low-molecular-weight peptides for facilitated intestinal absorption. These peptides exert a dual action once absorbed: they supply the specific amino acids of collagen (glycine, proline, hydroxyproline) as raw material, and certain dipeptides such as Pro-Hyp act as cellular messengers by stimulating dermal fibroblast activity. Meta-analyses of randomized trials have shown improvement in skin hydration and elasticity after 8 to 12 weeks of supplementation at doses of 2.5 to 10 g/day. In the formula, type I collagen is part of a complete synthesis network: glycine and L-lysine (present in the formula) provide the precursor amino acids, while vitamin C (also present) is the essential cofactor for the hydroxylation of proline and lysine, the key step in collagen maturation. Without vitamin C, the collagen triple helix cannot stabilize.
0 to 10 g
Tap to closeCollagen Types I and III
Tissue structureHydrolysed bovine collagen peptides, types I and III, sourced from bovine skin. Enzymatic hydrolysis reduces the molecular weight to 1,000-5,000 daltons, enabling cold-water solubility and facilitating intestinal absorption compared to non-hydrolysed native collagen. This matrix provides the amino acids specific to collagen (glycine, proline, hydroxyproline), which are scarce in other dietary protein sources. Manufactured in Europe (Italy/Netherlands). No additives, no major allergens (other than bovine origin). Halal and Kosher certified. Quality: Halal and Kosher certified.
Type I collagen in the form of hydrolyzed peptides. Type I collagen is the most abundant structural protein in the human body, constituting approximately 90% of total collagen, found in skin, bones, tendons and ligaments. Its endogenous production decreases by approximately 1 to 1.5% per year from age 25, a process accelerated by UV exposure, smoking and oxidative stress. Enzymatic hydrolysis produces low-molecular-weight peptides for facilitated intestinal absorption. These peptides exert a dual action once absorbed: they supply the specific amino acids of collagen (glycine, proline, hydroxyproline) as raw material, and certain dipeptides such as Pro-Hyp act as cellular messengers by stimulating dermal fibroblast activity. Meta-analyses of randomized trials have shown improvement in skin hydration and elasticity after 8 to 12 weeks of supplementation at doses of 2.5 to 10 g/day. In the formula, type I collagen is part of a complete synthesis network: glycine and L-lysine (present in the formula) provide the precursor amino acids, while vitamin C (also present) is the essential cofactor for the hydroxylation of proline and lysine, the key step in collagen maturation. Without vitamin C, the collagen triple helix cannot stabilize.
0 to 10 g
Copper
Oxidative stressCopper bisglycinate: each copper atom is chelated to two glycine molecules, the smallest amino acid naturally present in the body. This chelated bond protects copper from interaction with dietary fibres and phytates, which block the absorption of conventional inorganic forms (sulphate, oxide). Copper contributes to the normal function of the immune system and to the maintenance of normal connective tissues. Pure raw material. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Essential trace element present in minute amounts in the body, yet indispensable to numerous biological functions. Copper contributes to the maintenance of normal connective tissues, to the normal transport of iron in the body, to the normal functioning of the nervous system, to normal energy metabolism and to the protection of cells against oxidative stress. Copper is a cofactor of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic defense against free radicals. This enzyme works in tandem with zinc (also present in the formula in bisglycinate form), each occupying a distinct catalytic site on the same protein. Copper is also essential to the activity of lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin, the two proteins that give connective tissues their strength and elasticity. It also participates in iron transport via ceruloplasmin (iron is available in the formula for profiles that require it). In the bisglycinate form, where copper is chelated to two glycine molecules, it is absorbed via the amino acid transporters of the intestine. This absorption pathway limits interactions with other minerals and reduces the digestive irritation sometimes associated with inorganic copper salts.
0 to 1 mg
Tap to closeCopper
Oxidative stressCopper bisglycinate: each copper atom is chelated to two glycine molecules, the smallest amino acid naturally present in the body. This chelated bond protects copper from interaction with dietary fibres and phytates, which block the absorption of conventional inorganic forms (sulphate, oxide). Copper contributes to the normal function of the immune system and to the maintenance of normal connective tissues. Pure raw material. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Essential trace element present in minute amounts in the body, yet indispensable to numerous biological functions. Copper contributes to the maintenance of normal connective tissues, to the normal transport of iron in the body, to the normal functioning of the nervous system, to normal energy metabolism and to the protection of cells against oxidative stress. Copper is a cofactor of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic defense against free radicals. This enzyme works in tandem with zinc (also present in the formula in bisglycinate form), each occupying a distinct catalytic site on the same protein. Copper is also essential to the activity of lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin, the two proteins that give connective tissues their strength and elasticity. It also participates in iron transport via ceruloplasmin (iron is available in the formula for profiles that require it). In the bisglycinate form, where copper is chelated to two glycine molecules, it is absorbed via the amino acid transporters of the intestine. This absorption pathway limits interactions with other minerals and reduces the digestive irritation sometimes associated with inorganic copper salts.
0 to 1 mg
Creatine
Mitochondrial energyMicronised creatine monohydrate (200 mesh), vegan grade. Micronisation reduces particle size to an ultrafine level, improving dispersibility in solution and dissolution speed compared to standard creatine monohydrate. The monohydrate form is the most scientifically documented among all available creatine forms. Creatine is a molecule naturally synthesised by the body from arginine, glycine and methionine, stored primarily in skeletal muscle. Pure raw material. Quality: vegan, non-GMO, no excipient.
Often wrongly associated solely with bodybuilding, creatine is the most documented bioactive in human supplementation, with over 500 clinical trials. Naturally synthesized from three amino acids (including glycine, present in the formula), it fuels the phosphocreatine/ATP system: a universal energy buffer present in muscle, brain, heart and bone. Creatine increases physical performance in successive bursts of short-term, high-intensity exercise (effect obtained with 3 g/day). It is beyond muscle that recent data are most striking. A meta-analysis of six randomized trials demonstrated improvements in working memory and reasoning, with a more pronounced effect in older adults and under mental fatigue. Sarcopenia (progressive loss of muscle mass and function with age) is one of the most reliable predictors of loss of autonomy. In adults over 50, adding creatine to resistance training produces greater gains in lean mass and strength compared to exercise alone. Phosphocreatine reserves decline with age, making supplementation relevant for functional longevity. Long-term safety studies (up to 5 years) have shown no adverse effect on renal function: the elevation of serum creatinine (a creatine degradation product) does not reflect kidney dysfunction.
0 to 3.4 g
Tap to closeCreatine
Mitochondrial energyMicronised creatine monohydrate (200 mesh), vegan grade. Micronisation reduces particle size to an ultrafine level, improving dispersibility in solution and dissolution speed compared to standard creatine monohydrate. The monohydrate form is the most scientifically documented among all available creatine forms. Creatine is a molecule naturally synthesised by the body from arginine, glycine and methionine, stored primarily in skeletal muscle. Pure raw material. Quality: vegan, non-GMO, no excipient.
Often wrongly associated solely with bodybuilding, creatine is the most documented bioactive in human supplementation, with over 500 clinical trials. Naturally synthesized from three amino acids (including glycine, present in the formula), it fuels the phosphocreatine/ATP system: a universal energy buffer present in muscle, brain, heart and bone. Creatine increases physical performance in successive bursts of short-term, high-intensity exercise (effect obtained with 3 g/day). It is beyond muscle that recent data are most striking. A meta-analysis of six randomized trials demonstrated improvements in working memory and reasoning, with a more pronounced effect in older adults and under mental fatigue. Sarcopenia (progressive loss of muscle mass and function with age) is one of the most reliable predictors of loss of autonomy. In adults over 50, adding creatine to resistance training produces greater gains in lean mass and strength compared to exercise alone. Phosphocreatine reserves decline with age, making supplementation relevant for functional longevity. Long-term safety studies (up to 5 years) have shown no adverse effect on renal function: the elevation of serum creatinine (a creatine degradation product) does not reflect kidney dysfunction.
0 to 3.4 g
Curcumin
Systemic inflammationConcentrated extract of turmeric rhizome (Curcuma longa), standardised for total curcuminoids, the polyphenols responsible for its characteristic orange colour. Extraction with ethyl acetate, a food-grade solvent, yields a concentrated extract at approximately 25:1 ratio without resorting to harsh solvents. Turmeric is a spice used in Ayurvedic tradition for millennia. Pure raw material. As curcumin is naturally fat-soluble and poorly absorbed on its own, it is designed to be combined with a bioavailability enhancer in the final formula. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
The principal polyphenol of the turmeric rhizome (Curcuma longa), the golden spice at the heart of the Ayurvedic tradition for over 4,000 years. Curcumin is one of the most studied plant compounds in the world, with a body of research exceeding 15,000 scientific publications. Its naturally limited oral bioavailability has been the primary galenic challenge. In its native form, curcumin is rapidly metabolized by the liver. Micellar forms and phospholipid complexes multiply absorption by a factor of 20 to 185 depending on the technology. Meta-analyses of randomized controlled trials have documented its effects on joint comfort and systemic inflammation markers (CRP, IL-6), with clinically significant results over 8 to 12 weeks. Curcumin modulates numerous cellular signaling pathways involved in the inflammatory response and oxidative stress, which explains the diversity of research on the subject. It is also an effective free radical scavenger. In the formula, curcumin is paired with ginger (Zingiber officinale, also present), another member of the Zingiberaceae botanical family. These two rhizomes, used together for millennia in traditional medicine, present complementary activity spectra.
0 to 153 mg
Tap to closeCurcumin
Systemic inflammationConcentrated extract of turmeric rhizome (Curcuma longa), standardised for total curcuminoids, the polyphenols responsible for its characteristic orange colour. Extraction with ethyl acetate, a food-grade solvent, yields a concentrated extract at approximately 25:1 ratio without resorting to harsh solvents. Turmeric is a spice used in Ayurvedic tradition for millennia. Pure raw material. As curcumin is naturally fat-soluble and poorly absorbed on its own, it is designed to be combined with a bioavailability enhancer in the final formula. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
The principal polyphenol of the turmeric rhizome (Curcuma longa), the golden spice at the heart of the Ayurvedic tradition for over 4,000 years. Curcumin is one of the most studied plant compounds in the world, with a body of research exceeding 15,000 scientific publications. Its naturally limited oral bioavailability has been the primary galenic challenge. In its native form, curcumin is rapidly metabolized by the liver. Micellar forms and phospholipid complexes multiply absorption by a factor of 20 to 185 depending on the technology. Meta-analyses of randomized controlled trials have documented its effects on joint comfort and systemic inflammation markers (CRP, IL-6), with clinically significant results over 8 to 12 weeks. Curcumin modulates numerous cellular signaling pathways involved in the inflammatory response and oxidative stress, which explains the diversity of research on the subject. It is also an effective free radical scavenger. In the formula, curcumin is paired with ginger (Zingiber officinale, also present), another member of the Zingiberaceae botanical family. These two rhizomes, used together for millennia in traditional medicine, present complementary activity spectra.
0 to 153 mg
Galacto-oligosaccharides (GOS)
Microbiome & barrierGalacto-oligosaccharides (GOS) in soluble fibre form, produced by enzymatic transgalactosylation of lactose. GOS are prebiotics: non-digestible fibres that serve as a selective substrate for beneficial gut bacteria, particularly bifidobacteria. This concentrated form contains a spectrum of oligosaccharide chains from DP2 to DP8 (degree of polymerisation from 2 to 8 galactose units). Slightly sweet taste, good solubility. May contain traces of residual lactose. Quality: non-GMO.
Non-digestible prebiotic fibers produced by enzymatic transgalactosylation of lactose. GOS (galacto-oligosaccharides) are structurally similar to human milk oligosaccharides (HMOs), the natural fibers that shape the infant microbiota from the very first hours of life. Not digested in the small intestine, GOS reach the colon intact where they are selectively fermented by bifidobacteria and lactobacilli, the bacterial genera that are pillars of a balanced microbiota. This fermentation produces short-chain fatty acids (butyrate, propionate, acetate), energy sources for colonocytes and modulators of intestinal pH. Butyrate nourishes the cells of the colonic mucosa and contributes to intestinal barrier function. GOS differ from FOS (fructo-oligosaccharides) in their galactosidic structure, which gives them superior digestive tolerance with less bloating. In the formula, GOS selectively feed Bifidobacterium lactis (present in the formula), while Bacillus subtilis (also present) brings complementary microbial diversity through its spore form. Acacia fiber adds gradual prebiotic fermentation. This network approach aims to support microbiota diversity, whose decline is a marker of biological aging.
0 to 5 g
Tap to closeGalacto-oligosaccharides (GOS)
Microbiome & barrierGalacto-oligosaccharides (GOS) in soluble fibre form, produced by enzymatic transgalactosylation of lactose. GOS are prebiotics: non-digestible fibres that serve as a selective substrate for beneficial gut bacteria, particularly bifidobacteria. This concentrated form contains a spectrum of oligosaccharide chains from DP2 to DP8 (degree of polymerisation from 2 to 8 galactose units). Slightly sweet taste, good solubility. May contain traces of residual lactose. Quality: non-GMO.
Non-digestible prebiotic fibers produced by enzymatic transgalactosylation of lactose. GOS (galacto-oligosaccharides) are structurally similar to human milk oligosaccharides (HMOs), the natural fibers that shape the infant microbiota from the very first hours of life. Not digested in the small intestine, GOS reach the colon intact where they are selectively fermented by bifidobacteria and lactobacilli, the bacterial genera that are pillars of a balanced microbiota. This fermentation produces short-chain fatty acids (butyrate, propionate, acetate), energy sources for colonocytes and modulators of intestinal pH. Butyrate nourishes the cells of the colonic mucosa and contributes to intestinal barrier function. GOS differ from FOS (fructo-oligosaccharides) in their galactosidic structure, which gives them superior digestive tolerance with less bloating. In the formula, GOS selectively feed Bifidobacterium lactis (present in the formula), while Bacillus subtilis (also present) brings complementary microbial diversity through its spore form. Acacia fiber adds gradual prebiotic fermentation. This network approach aims to support microbiota diversity, whose decline is a marker of biological aging.
0 to 5 g
Ginger
Systemic inflammationGinger rhizome extract (Zingiber officinale), standardised in gingerols, the primary bioactive compounds of the plant. Extraction is performed from the whole rhizome, and the extract is encapsulated in beta-cyclodextrin: a cyclic plant-derived oligosaccharide that forms a molecular cage around gingerols. This encapsulation protects active compounds from oxidation and gastric degradation while improving their aqueous solubility. Ginger has been used for millennia in Ayurvedic and Chinese traditions. Quality: non-GMO, pesticide-free.
Rhizome of Zingiber officinale, a tropical plant used in Asian culinary and herbal traditions for millennia. Ginger owes its properties to its richness in gingerols and shogaols, pungent phenolic compounds. 6-gingerol is the main bioactive in fresh ginger, while 6-shogaol, produced by thermal dehydration, predominates in dried and concentrated forms. Ginger contributes to digestive comfort and the normal functioning of the intestinal tract. Randomized clinical trials have confirmed its efficacy on nausea in various contexts (motion sickness, postoperative, pregnancy), at doses of 1 to 2 g/day. The warming properties of ginger are linked to the activation of heat-sensing receptors, triggering peripheral vasodilation. Recent meta-analyses have documented significant effects on systemic inflammatory markers (CRP) and glycemic profile. In the formula, ginger is paired with curcumin (also present), another member of the Zingiberaceae botanical family. These two rhizomes, combined for millennia in Asian medicinal traditions, present complementary activity spectra.
0 to 120 mg
Tap to closeGinger
Systemic inflammationGinger rhizome extract (Zingiber officinale), standardised in gingerols, the primary bioactive compounds of the plant. Extraction is performed from the whole rhizome, and the extract is encapsulated in beta-cyclodextrin: a cyclic plant-derived oligosaccharide that forms a molecular cage around gingerols. This encapsulation protects active compounds from oxidation and gastric degradation while improving their aqueous solubility. Ginger has been used for millennia in Ayurvedic and Chinese traditions. Quality: non-GMO, pesticide-free.
Rhizome of Zingiber officinale, a tropical plant used in Asian culinary and herbal traditions for millennia. Ginger owes its properties to its richness in gingerols and shogaols, pungent phenolic compounds. 6-gingerol is the main bioactive in fresh ginger, while 6-shogaol, produced by thermal dehydration, predominates in dried and concentrated forms. Ginger contributes to digestive comfort and the normal functioning of the intestinal tract. Randomized clinical trials have confirmed its efficacy on nausea in various contexts (motion sickness, postoperative, pregnancy), at doses of 1 to 2 g/day. The warming properties of ginger are linked to the activation of heat-sensing receptors, triggering peripheral vasodilation. Recent meta-analyses have documented significant effects on systemic inflammatory markers (CRP) and glycemic profile. In the formula, ginger is paired with curcumin (also present), another member of the Zingiberaceae botanical family. These two rhizomes, combined for millennia in Asian medicinal traditions, present complementary activity spectra.
0 to 120 mg
Glucosamine Sulfate
Tissue structureGlucosamine sulphate stabilised with potassium chloride (2KCl), obtained through plant-based fermentation. Unlike conventional glucosamine extracted from crustacean shells, this form is produced by microbial fermentation: no marine allergens, suitable for vegan diets. The 2KCl stabilisation preserves the integrity of glucosamine sulphate over time, essential to its activity. Quality: vegan, non-GMO.
Amino sugar naturally present in human cartilage, where it is a key constituent of glycosaminoglycans and proteoglycans, the molecules that give cartilage its cushioning and mechanical resistance properties. Glucosamine is the direct precursor of hyaluronic acid and keratan sulfates, essential components of the extracellular matrix of articular cartilage. Its endogenous production by chondrocytes (cartilage cells) decreases with age, contributing to the progressive thinning of cartilage observed during aging. The sulfate form is preferred because the sulfate group is itself necessary for the synthesis of sulfated glycosaminoglycans. Numerous clinical studies have evaluated glucosamine sulfate at doses of 1,500 mg/day, making it one of the most documented joint supplements in the world. Randomized trials spanning 3 years have shown a slowing of articular cartilage thickness loss measured by radiography. In the formula, glucosamine works in complementarity with undenatured type II collagen (also present). These two actives take distinct pathways: glucosamine provides the building blocks for glycosaminoglycans, while type II collagen modulates the immune response toward cartilage through oral tolerance. Two complementary mechanisms to support joint comfort.
0 to 1,118 mg
Tap to closeGlucosamine Sulfate
Tissue structureGlucosamine sulphate stabilised with potassium chloride (2KCl), obtained through plant-based fermentation. Unlike conventional glucosamine extracted from crustacean shells, this form is produced by microbial fermentation: no marine allergens, suitable for vegan diets. The 2KCl stabilisation preserves the integrity of glucosamine sulphate over time, essential to its activity. Quality: vegan, non-GMO.
Amino sugar naturally present in human cartilage, where it is a key constituent of glycosaminoglycans and proteoglycans, the molecules that give cartilage its cushioning and mechanical resistance properties. Glucosamine is the direct precursor of hyaluronic acid and keratan sulfates, essential components of the extracellular matrix of articular cartilage. Its endogenous production by chondrocytes (cartilage cells) decreases with age, contributing to the progressive thinning of cartilage observed during aging. The sulfate form is preferred because the sulfate group is itself necessary for the synthesis of sulfated glycosaminoglycans. Numerous clinical studies have evaluated glucosamine sulfate at doses of 1,500 mg/day, making it one of the most documented joint supplements in the world. Randomized trials spanning 3 years have shown a slowing of articular cartilage thickness loss measured by radiography. In the formula, glucosamine works in complementarity with undenatured type II collagen (also present). These two actives take distinct pathways: glucosamine provides the building blocks for glycosaminoglycans, while type II collagen modulates the immune response toward cartilage through oral tolerance. Two complementary mechanisms to support joint comfort.
0 to 1,118 mg
Glycine
Autophagy & SenescenceFree-form L-Glycine, vegan grade. Glycine is the smallest and simplest amino acid. It accounts for approximately one third of the amino acids in collagen and is involved in the synthesis of glutathione, the body's primary intracellular antioxidant. This free form (not bound to another compound) allows direct and rapid intestinal absorption. Highly soluble in water, it disperses readily in a formula. Quality: vegan, non-GMO.
The simplest and smallest amino acid, yet far from the least important: glycine accounts for approximately one third of the amino acids in collagen, the most abundant protein in the human body. It is a conditionally essential amino acid whose endogenous synthesis does not cover all metabolic needs. Human biosynthesis produces approximately 3 g/day, while total requirements exceed 10 g/day, a structural deficit that the modern diet struggles to fill. Glycine occupies a metabolic crossroads in the formula. It is a direct precursor of glutathione (the body's major antioxidant tripeptide), alongside NAC which provides cysteine (both present in the formula). It is also a precursor of creatine (also in the formula), participating in the synthesis of this universal energy buffer. Finally, it provides one of the structural amino acids for type I collagen and type II collagen (both present). Beyond these synergies, glycine participates in the hepatic conjugation of bile acids and acts as an inhibitory neurotransmitter in the central nervous system. Clinical trials have documented its role in sleep quality, with subjective improvement in morning fatigue at 3 g before bedtime.
0 to 2 g
Tap to closeGlycine
Autophagy & SenescenceFree-form L-Glycine, vegan grade. Glycine is the smallest and simplest amino acid. It accounts for approximately one third of the amino acids in collagen and is involved in the synthesis of glutathione, the body's primary intracellular antioxidant. This free form (not bound to another compound) allows direct and rapid intestinal absorption. Highly soluble in water, it disperses readily in a formula. Quality: vegan, non-GMO.
The simplest and smallest amino acid, yet far from the least important: glycine accounts for approximately one third of the amino acids in collagen, the most abundant protein in the human body. It is a conditionally essential amino acid whose endogenous synthesis does not cover all metabolic needs. Human biosynthesis produces approximately 3 g/day, while total requirements exceed 10 g/day, a structural deficit that the modern diet struggles to fill. Glycine occupies a metabolic crossroads in the formula. It is a direct precursor of glutathione (the body's major antioxidant tripeptide), alongside NAC which provides cysteine (both present in the formula). It is also a precursor of creatine (also in the formula), participating in the synthesis of this universal energy buffer. Finally, it provides one of the structural amino acids for type I collagen and type II collagen (both present). Beyond these synergies, glycine participates in the hepatic conjugation of bile acids and acts as an inhibitory neurotransmitter in the central nervous system. Clinical trials have documented its role in sleep quality, with subjective improvement in morning fatigue at 3 g before bedtime.
0 to 2 g
Hyaluronic Acid
Tissue structureExceptionHYAL Star, a patented sodium hyaluronate by Roelmi HPC (Italy). Its specificity: a multi-molecular weight spectrum combining several hyaluronic acid molecular weights in a single ingredient. High molecular weight fractions form a hydrating surface film, while low molecular weight fractions reach deeper layers. Hyaluronic acid is a glycosaminoglycan naturally present in the skin and synovial fluid, capable of retaining up to 1,000 times its weight in water. Produced by bacterial fermentation, with no animal origin. Quality: vegan.
High-molecular-weight glycosaminoglycan, hyaluronic acid is naturally present in the skin, synovial fluid of joints and the vitreous humor of the eye. Each molecule can retain up to 1,000 times its weight in water, making it the body's main endogenous hydrating agent. The human body contains approximately 15 g, of which one third is renewed each day. This rapid turnover slows with age, contributing to the progressive loss of tissue hydration and volume. In the skin, hyaluronic acid occupies the space between the collagen and elastin fibers of the dermis, where it maintains turgor and tissue firmness. In the synovial fluid, it provides the viscosity needed for lubrication and cushioning of joint surfaces. Produced by bacterial fermentation (without animal origin), oral high-molecular-weight hyaluronic acid has been the subject of randomized clinical trials showing measurable improvement in skin hydration by corneometry after 4 to 8 weeks of supplementation. Its safety profile is favorable, with a considerable track record of use in nutrition and cosmetics.
0 to 200 mg
Tap to closeHyaluronic Acid
Tissue structureExceptionHYAL Star, a patented sodium hyaluronate by Roelmi HPC (Italy). Its specificity: a multi-molecular weight spectrum combining several hyaluronic acid molecular weights in a single ingredient. High molecular weight fractions form a hydrating surface film, while low molecular weight fractions reach deeper layers. Hyaluronic acid is a glycosaminoglycan naturally present in the skin and synovial fluid, capable of retaining up to 1,000 times its weight in water. Produced by bacterial fermentation, with no animal origin. Quality: vegan.
High-molecular-weight glycosaminoglycan, hyaluronic acid is naturally present in the skin, synovial fluid of joints and the vitreous humor of the eye. Each molecule can retain up to 1,000 times its weight in water, making it the body's main endogenous hydrating agent. The human body contains approximately 15 g, of which one third is renewed each day. This rapid turnover slows with age, contributing to the progressive loss of tissue hydration and volume. In the skin, hyaluronic acid occupies the space between the collagen and elastin fibers of the dermis, where it maintains turgor and tissue firmness. In the synovial fluid, it provides the viscosity needed for lubrication and cushioning of joint surfaces. Produced by bacterial fermentation (without animal origin), oral high-molecular-weight hyaluronic acid has been the subject of randomized clinical trials showing measurable improvement in skin hydration by corneometry after 4 to 8 weeks of supplementation. Its safety profile is favorable, with a considerable track record of use in nutrition and cosmetics.
0 to 200 mg
Iodine
Cellular metabolismPotassium iodide (KI), synthesised in Europe. Potassium iodide is the most stable and bioavailable form of iodine in oral supplementation. Its high water solubility (1,440 g/L) ensures homogeneous dispersion in the formula. Iodine contributes to normal thyroid function and normal cognitive function. Quality: vegan, non-GMO, allergen-free, residual solvent-free, Kosher certified.
Iodine contributes to normal thyroid function, normal cognitive function and normal energy metabolism. An essential constituent of the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine), iodine holds a central position in regulating the basal metabolism of virtually every cell in the body. The thyroid concentrates circulating iodine to synthesize T4, which is then converted to T3 (the active form) by enzymes called deiodinases, whose activity depends on selenium (also present in the formula). This iodine-selenium synergy is essential for optimal thyroid function. Despite table salt iodization in many countries, nutritional surveys reveal that certain populations remain at suboptimal intake, particularly people limiting their consumption of salt, dairy or fish. Thyroid function directly influences thermogenesis, heart rate, cell renewal and cognitive functions. Its progressive decline with age makes monitoring iodine status particularly relevant from a longevity perspective. Potassium iodide form, stable and well absorbed.
0 to 150 µg
Tap to closeIodine
Cellular metabolismPotassium iodide (KI), synthesised in Europe. Potassium iodide is the most stable and bioavailable form of iodine in oral supplementation. Its high water solubility (1,440 g/L) ensures homogeneous dispersion in the formula. Iodine contributes to normal thyroid function and normal cognitive function. Quality: vegan, non-GMO, allergen-free, residual solvent-free, Kosher certified.
Iodine contributes to normal thyroid function, normal cognitive function and normal energy metabolism. An essential constituent of the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine), iodine holds a central position in regulating the basal metabolism of virtually every cell in the body. The thyroid concentrates circulating iodine to synthesize T4, which is then converted to T3 (the active form) by enzymes called deiodinases, whose activity depends on selenium (also present in the formula). This iodine-selenium synergy is essential for optimal thyroid function. Despite table salt iodization in many countries, nutritional surveys reveal that certain populations remain at suboptimal intake, particularly people limiting their consumption of salt, dairy or fish. Thyroid function directly influences thermogenesis, heart rate, cell renewal and cognitive functions. Its progressive decline with age makes monitoring iodine status particularly relevant from a longevity perspective. Potassium iodide form, stable and well absorbed.
0 to 150 µg
Iron
Mitochondrial energyFerrous bisglycinate: each iron atom (Fe2+) is chelated to two glycine molecules, the smallest natural amino acid. Chelation means iron is stably bonded to an amino acid, allowing it to cross the intestinal wall via amino acid transporters rather than conventional iron pathways. Result: significantly superior absorption compared to classic ferrous salts (sulphate, fumarate, gluconate) and optimal digestive tolerance. Iron contributes to the reduction of tiredness and to normal oxygen transport in the body. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Iron contributes to the normal formation of red blood cells and hemoglobin, to normal oxygen transport in the body and to the reduction of tiredness and fatigue. Included only according to your profile. Iron is a double-edged element: indispensable for oxygen transport and cellular respiration, but potentially pro-oxidant in excess via the Fenton reaction. This is why its supplementation is personalized and not systematic in the formula. Vitamin C (present in the formula) increases non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract. The balance with zinc and copper (also present in the formula in bisglycinate form) is carefully calibrated to avoid mineral absorption competition. The bisglycinate form (iron chelated to two glycine molecules) is absorbed via amino acid transporters in the intestine, bypassing the DMT1 transporter for ionic iron. This distinct absorption mechanism significantly reduces classic digestive side effects (nausea, constipation, dark stools) and provides a bioavailability 3 to 4 times greater than ferrous sulfate, allowing lower effective doses that are better tolerated.
0 to 21 mg
Tap to closeIron
Mitochondrial energyFerrous bisglycinate: each iron atom (Fe2+) is chelated to two glycine molecules, the smallest natural amino acid. Chelation means iron is stably bonded to an amino acid, allowing it to cross the intestinal wall via amino acid transporters rather than conventional iron pathways. Result: significantly superior absorption compared to classic ferrous salts (sulphate, fumarate, gluconate) and optimal digestive tolerance. Iron contributes to the reduction of tiredness and to normal oxygen transport in the body. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Iron contributes to the normal formation of red blood cells and hemoglobin, to normal oxygen transport in the body and to the reduction of tiredness and fatigue. Included only according to your profile. Iron is a double-edged element: indispensable for oxygen transport and cellular respiration, but potentially pro-oxidant in excess via the Fenton reaction. This is why its supplementation is personalized and not systematic in the formula. Vitamin C (present in the formula) increases non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract. The balance with zinc and copper (also present in the formula in bisglycinate form) is carefully calibrated to avoid mineral absorption competition. The bisglycinate form (iron chelated to two glycine molecules) is absorbed via amino acid transporters in the intestine, bypassing the DMT1 transporter for ionic iron. This distinct absorption mechanism significantly reduces classic digestive side effects (nausea, constipation, dark stools) and provides a bioavailability 3 to 4 times greater than ferrous sulfate, allowing lower effective doses that are better tolerated.
0 to 21 mg
L-Lysine
Tissue structureVegan-grade L-Lysine HCl, obtained through microbial fermentation from corn. Lysine is an essential amino acid: the body cannot synthesise it, so it must be obtained from the diet. The hydrochloride (HCl) form ensures superior stability and solubility compared to free-base L-lysine. The plant-based fermentation process avoids any animal source and guarantees high purity. Quality: vegan, non-GMO.
Essential amino acid that the body cannot synthesize. L-lysine is a structural constituent of collagen, where it participates in the cross-links that stabilize the triple helix, the molecular architecture responsible for collagen's mechanical strength. In the formula, it forms part of a coherent collagen support network alongside type I collagen peptides, glycine and vitamin C (an indispensable cofactor for the hydroxylation of lysine and proline in the collagen matrix). Beyond its structural role, lysine is a precursor of carnitine, a molecule involved in the transport of fatty acids to mitochondria for energy production from fats. It also facilitates intestinal calcium absorption and reduces urinary calcium excretion, indirectly contributing to the maintenance of bone mineral density. Vegetarian and vegan diets may present a risk of insufficient lysine intake, as cereals are relatively low in this amino acid.
0 to 500 mg
Tap to closeL-Lysine
Tissue structureVegan-grade L-Lysine HCl, obtained through microbial fermentation from corn. Lysine is an essential amino acid: the body cannot synthesise it, so it must be obtained from the diet. The hydrochloride (HCl) form ensures superior stability and solubility compared to free-base L-lysine. The plant-based fermentation process avoids any animal source and guarantees high purity. Quality: vegan, non-GMO.
Essential amino acid that the body cannot synthesize. L-lysine is a structural constituent of collagen, where it participates in the cross-links that stabilize the triple helix, the molecular architecture responsible for collagen's mechanical strength. In the formula, it forms part of a coherent collagen support network alongside type I collagen peptides, glycine and vitamin C (an indispensable cofactor for the hydroxylation of lysine and proline in the collagen matrix). Beyond its structural role, lysine is a precursor of carnitine, a molecule involved in the transport of fatty acids to mitochondria for energy production from fats. It also facilitates intestinal calcium absorption and reduces urinary calcium excretion, indirectly contributing to the maintenance of bone mineral density. Vegetarian and vegan diets may present a risk of insufficient lysine intake, as cereals are relatively low in this amino acid.
0 to 500 mg
L-Theanine
Systemic inflammationPure L-Theanine, synthesised by acylation reaction between L-pyroglutamic acid and ethylamine (both derived from corn), then crystallised in ethanol (EU-compliant solvent). L-theanine is a non-proteinogenic amino acid, meaning it does not form part of the body's proteins. In nature, it is found almost exclusively in tea leaves (Camellia sinensis). This biomimetic synthesis reproduces the molecule identical to that found in tea. Quality: vegan, non-GMO.
Non-proteinogenic amino acid found almost exclusively in tea leaves (Camellia sinensis), where it represents up to 50% of free amino acids. It is L-theanine that gives green tea its distinctive umami character. Structurally analogous to glutamate, it has been studied since the 1960s in Japan. L-theanine crosses the blood-brain barrier and reaches the brain approximately 30 minutes after oral ingestion. Electroencephalographic studies show that it promotes the production of alpha waves (8-13 Hz), a brain state associated with wakeful relaxation and calm focus. This state of serene alertness, between drowsiness and mental hyperactivity, is precisely what individuals facing sustained cognitive demands seek. Several controlled trials have also explored its influence on sleep quality, with results suggesting improvement in sleep onset and subjective perception of rest. Its safety profile is firmly documented by decades of consumption through tea, and supplementation studies report no significant side effects at usual doses.
0 to 200 mg
Tap to closeL-Theanine
Systemic inflammationPure L-Theanine, synthesised by acylation reaction between L-pyroglutamic acid and ethylamine (both derived from corn), then crystallised in ethanol (EU-compliant solvent). L-theanine is a non-proteinogenic amino acid, meaning it does not form part of the body's proteins. In nature, it is found almost exclusively in tea leaves (Camellia sinensis). This biomimetic synthesis reproduces the molecule identical to that found in tea. Quality: vegan, non-GMO.
Non-proteinogenic amino acid found almost exclusively in tea leaves (Camellia sinensis), where it represents up to 50% of free amino acids. It is L-theanine that gives green tea its distinctive umami character. Structurally analogous to glutamate, it has been studied since the 1960s in Japan. L-theanine crosses the blood-brain barrier and reaches the brain approximately 30 minutes after oral ingestion. Electroencephalographic studies show that it promotes the production of alpha waves (8-13 Hz), a brain state associated with wakeful relaxation and calm focus. This state of serene alertness, between drowsiness and mental hyperactivity, is precisely what individuals facing sustained cognitive demands seek. Several controlled trials have also explored its influence on sleep quality, with results suggesting improvement in sleep onset and subjective perception of rest. Its safety profile is firmly documented by decades of consumption through tea, and supplementation studies report no significant side effects at usual doses.
0 to 200 mg
Lutein
Oxidative stressLutein extracted from Calendula officinalis (marigold) flowers, through a preservative-free water-ethanol process. Lutein is a carotenoid of the xanthophyll family. It naturally concentrates in the macula, the central area of the retina responsible for fine vision. Unlike carotenoids such as beta-carotene, lutein is not synthesised by the human body: it must be obtained from the diet. Extraction from the whole flower preserves the natural carotenoid profile. Quality: vegan, non-GMO, pesticide-free, preservative-free, Halal and Kosher certified.
Carotenoid of the xanthophyll family, extracted from marigold petals (Tagetes erecta). Lutein naturally concentrates in the macula of the retina, at the periphery of the fovea, where together with zeaxanthin (present in the formula and concentrated at the center of the fovea) it constitutes the macular pigment. This pigment is the eye's natural optical filter: it selectively absorbs high-energy blue light (400-500 nm), protecting photoreceptors from cumulative photochemical damage. In a context of increasing exposure to digital screens and LED lighting, the daily blue light load has risen considerably, reinforcing interest in the macular pigment. The optical density of the macular pigment (MPOD) varies according to dietary intake of lutein and zeaxanthin. This parameter is measurable by non-invasive techniques and correlated with long-term retinal health. Astaxanthin (also present in the formula) complements this carotenoid protection through its action at the cell membrane level. The body does not synthesize lutein: it must be provided through diet or supplementation.
0 to 10 mg
Tap to closeLutein
Oxidative stressLutein extracted from Calendula officinalis (marigold) flowers, through a preservative-free water-ethanol process. Lutein is a carotenoid of the xanthophyll family. It naturally concentrates in the macula, the central area of the retina responsible for fine vision. Unlike carotenoids such as beta-carotene, lutein is not synthesised by the human body: it must be obtained from the diet. Extraction from the whole flower preserves the natural carotenoid profile. Quality: vegan, non-GMO, pesticide-free, preservative-free, Halal and Kosher certified.
Carotenoid of the xanthophyll family, extracted from marigold petals (Tagetes erecta). Lutein naturally concentrates in the macula of the retina, at the periphery of the fovea, where together with zeaxanthin (present in the formula and concentrated at the center of the fovea) it constitutes the macular pigment. This pigment is the eye's natural optical filter: it selectively absorbs high-energy blue light (400-500 nm), protecting photoreceptors from cumulative photochemical damage. In a context of increasing exposure to digital screens and LED lighting, the daily blue light load has risen considerably, reinforcing interest in the macular pigment. The optical density of the macular pigment (MPOD) varies according to dietary intake of lutein and zeaxanthin. This parameter is measurable by non-invasive techniques and correlated with long-term retinal health. Astaxanthin (also present in the formula) complements this carotenoid protection through its action at the cell membrane level. The body does not synthesize lutein: it must be provided through diet or supplementation.
0 to 10 mg
Magnesium
Genomic stabilityAnhydrous magnesium bisglycinate, fully reacted: each magnesium atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Unlike partially chelated bisglycinate on the market, this form contains no residual oxide or inorganic magnesium. The anhydrous form concentrates more elemental magnesium per gram. Result: significantly superior intestinal absorption compared to classic forms (oxide, citrate) and optimal digestive tolerance with no laxative effect. Magnesium contributes to the reduction of tiredness and to normal functioning of the nervous system. Quality: vegan, non-GMO, no excipient.
Magnesium contributes to the reduction of tiredness and fatigue, to normal nervous system function, to normal muscle function, to normal energy metabolism, to normal psychological functions and to electrolyte balance. Cofactor of over 600 enzymatic reactions, magnesium is the most broadly involved mineral in human cellular metabolism. It forms the Mg-ATP complex, the active form of cellular energy, and is involved in DNA replication, protein synthesis, nerve transmission and muscle contraction. DNA repair systems also depend on its presence. A meta-analysis encompassing over 500,000 participants found that an increase of 100 mg/day of dietary magnesium is associated with a 22% reduction in heart failure risk and a 19% reduction in type 2 diabetes risk. Epidemiological studies estimate that approximately 50 to 75% of the Western population does not reach the recommended daily intake. In the formula, magnesium participates in the bone axis alongside vitamin D3, vitamin K2-MK7, boron and CaAKG. Bisglycinate form for superior intestinal absorption compared to oxide or citrate forms, without the osmotic laxative effect that limits the tolerable doses of the latter.
0 to 360 mg
Tap to closeMagnesium
Genomic stabilityAnhydrous magnesium bisglycinate, fully reacted: each magnesium atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Unlike partially chelated bisglycinate on the market, this form contains no residual oxide or inorganic magnesium. The anhydrous form concentrates more elemental magnesium per gram. Result: significantly superior intestinal absorption compared to classic forms (oxide, citrate) and optimal digestive tolerance with no laxative effect. Magnesium contributes to the reduction of tiredness and to normal functioning of the nervous system. Quality: vegan, non-GMO, no excipient.
Magnesium contributes to the reduction of tiredness and fatigue, to normal nervous system function, to normal muscle function, to normal energy metabolism, to normal psychological functions and to electrolyte balance. Cofactor of over 600 enzymatic reactions, magnesium is the most broadly involved mineral in human cellular metabolism. It forms the Mg-ATP complex, the active form of cellular energy, and is involved in DNA replication, protein synthesis, nerve transmission and muscle contraction. DNA repair systems also depend on its presence. A meta-analysis encompassing over 500,000 participants found that an increase of 100 mg/day of dietary magnesium is associated with a 22% reduction in heart failure risk and a 19% reduction in type 2 diabetes risk. Epidemiological studies estimate that approximately 50 to 75% of the Western population does not reach the recommended daily intake. In the formula, magnesium participates in the bone axis alongside vitamin D3, vitamin K2-MK7, boron and CaAKG. Bisglycinate form for superior intestinal absorption compared to oxide or citrate forms, without the osmotic laxative effect that limits the tolerable doses of the latter.
0 to 360 mg
Maitake
ImmunosenescenceFruiting body extract of maitake (Grifola frondosa), standardised in polysaccharides. Maitake, also known as 'hen of the woods', is an edible mushroom that is cultivated and manually harvested. Extraction is performed with water then purified with ethanol, a process that concentrates polysaccharides, particularly beta-glucans: soluble fibres found in the cell wall of mushrooms. The 8:1 extraction ratio means 8 kg of fresh fruiting body yield 1 kg of extract. Most common extracts on the market offer only simple aqueous extraction, without triterpenes. Quality: vegan, non-GMO, pesticide-free.
Large edible mushroom (Grifola frondosa), nicknamed 'hen of the woods' for its characteristic shape of cascading overlapping caps. A treasure of traditional Japanese mycology, maitake has been consumed for centuries both for its culinary qualities and its properties in the herbal tradition. Its composition stands out for its richness in specific beta-glucans called D-fraction, high-molecular-weight polysaccharides whose branched beta-1,3/1,6 structure interacts with innate immunity receptors. Maitake also contains ergosterols (precursors of vitamin D2), B vitamins and minerals. In the formula, it forms a complementary duo with reishi (also present): where maitake primarily contributes its D-fraction beta-glucans, reishi enriches the spectrum with its triterpenes (ganoderic acids), a family of compounds exclusive to the Ganoderma genus. This complementarity between polysaccharides and triterpenes reflects the approach of contemporary functional mycology. The extract is standardized in polysaccharides to ensure consistent active compound content.
0 to 1.2 g
Tap to closeMaitake
ImmunosenescenceFruiting body extract of maitake (Grifola frondosa), standardised in polysaccharides. Maitake, also known as 'hen of the woods', is an edible mushroom that is cultivated and manually harvested. Extraction is performed with water then purified with ethanol, a process that concentrates polysaccharides, particularly beta-glucans: soluble fibres found in the cell wall of mushrooms. The 8:1 extraction ratio means 8 kg of fresh fruiting body yield 1 kg of extract. Most common extracts on the market offer only simple aqueous extraction, without triterpenes. Quality: vegan, non-GMO, pesticide-free.
Large edible mushroom (Grifola frondosa), nicknamed 'hen of the woods' for its characteristic shape of cascading overlapping caps. A treasure of traditional Japanese mycology, maitake has been consumed for centuries both for its culinary qualities and its properties in the herbal tradition. Its composition stands out for its richness in specific beta-glucans called D-fraction, high-molecular-weight polysaccharides whose branched beta-1,3/1,6 structure interacts with innate immunity receptors. Maitake also contains ergosterols (precursors of vitamin D2), B vitamins and minerals. In the formula, it forms a complementary duo with reishi (also present): where maitake primarily contributes its D-fraction beta-glucans, reishi enriches the spectrum with its triterpenes (ganoderic acids), a family of compounds exclusive to the Ganoderma genus. This complementarity between polysaccharides and triterpenes reflects the approach of contemporary functional mycology. The extract is standardized in polysaccharides to ensure consistent active compound content.
0 to 1.2 g
N-Acetylcysteine
Oxidative stressN-Acetyl-L-Cysteine produced via fermentation. The acetyl group shields cysteine from oxidation during digestion, allowing significantly higher intestinal absorption than free L-cysteine. Once absorbed, NAC releases cysteine, the rate-limiting sulfur amino acid in glutathione biosynthesis, the body's primary cellular defence system. Unlike conventional chemically synthesised forms, this NAC is produced through fermentation. Freely soluble in water. Quality: vegan, non-GMO, allergen-free, Halal and Kosher certified.
Acetylated form of cysteine offering superior oral bioavailability compared to free cysteine, which oxidizes spontaneously in the digestive tract. N-acetylcysteine is the most effective precursor of glutathione, the body's main intracellular antioxidant. Glutathione is a sulfur-containing tripeptide composed of three amino acids: glutamate, cysteine and glycine. Its synthesis is limited by cysteine availability, the most fragile link. NAC resolves this limitation by providing cysteine in stable form. Glycine (also present in the formula) supplies the second component, while glutamate is abundant in the body. The formula thus brings together both rate-limiting substrates of glutathione synthesis. NAC also participates in phase II hepatic detoxification and in the regeneration of oxidized vitamins C and E. Furthermore, the cysteine provided by NAC is also a precursor of taurine (present in the formula), a sulfur amino acid whose tissue concentrations decline with age. NAC has been used in Europe for several decades, with a safety profile well documented across tens of thousands of patients.
0 to 600 mg
Tap to closeN-Acetylcysteine
Oxidative stressN-Acetyl-L-Cysteine produced via fermentation. The acetyl group shields cysteine from oxidation during digestion, allowing significantly higher intestinal absorption than free L-cysteine. Once absorbed, NAC releases cysteine, the rate-limiting sulfur amino acid in glutathione biosynthesis, the body's primary cellular defence system. Unlike conventional chemically synthesised forms, this NAC is produced through fermentation. Freely soluble in water. Quality: vegan, non-GMO, allergen-free, Halal and Kosher certified.
Acetylated form of cysteine offering superior oral bioavailability compared to free cysteine, which oxidizes spontaneously in the digestive tract. N-acetylcysteine is the most effective precursor of glutathione, the body's main intracellular antioxidant. Glutathione is a sulfur-containing tripeptide composed of three amino acids: glutamate, cysteine and glycine. Its synthesis is limited by cysteine availability, the most fragile link. NAC resolves this limitation by providing cysteine in stable form. Glycine (also present in the formula) supplies the second component, while glutamate is abundant in the body. The formula thus brings together both rate-limiting substrates of glutathione synthesis. NAC also participates in phase II hepatic detoxification and in the regeneration of oxidized vitamins C and E. Furthermore, the cysteine provided by NAC is also a precursor of taurine (present in the formula), a sulfur amino acid whose tissue concentrations decline with age. NAC has been used in Europe for several decades, with a safety profile well documented across tens of thousands of patients.
0 to 600 mg
Nicotinamide Riboside
Mitochondrial energyNicotinamide riboside chloride, a stabilised form of vitamin B3 naturally found in milk. Direct precursor to NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme present in every cell and involved in energy metabolism. Unlike conventional nicotinamide or nicotinic acid, nicotinamide riboside uses the nucleotide salvage pathway, a more direct metabolic route to NAD+. The chloride form ensures optimal stability at ambient temperature. Quality: non-GMO.
Form of vitamin B3 identified in milk and certain foods. Nicotinamide riboside is a direct precursor of NAD+ (nicotinamide adenine dinucleotide) via the nucleotide salvage pathway. NAD+ is a coenzyme present in every living cell, involved in hundreds of metabolic reactions. It plays a dual fundamental role: coenzyme in energy metabolism (glycolysis, Krebs cycle, mitochondrial respiratory chain) and substrate consumed by DNA repair and cellular maintenance enzymes. NAD+ levels decline by 40 to 60% between ages 40 and 60, a decline correlated with many aspects of biological aging. NR is the NAD+ precursor form with the best characterized human pharmacokinetics: clinical trials confirm a biochemical elevation of blood and tissue NAD+. Long-term functional benefits are the subject of ongoing studies in larger populations. In the formula, NR pairs with PQQ (also present), which supports mitochondrial renewal. These two compounds act complementarily: NR fuels energy production via NAD+, while PQQ promotes the genesis of new mitochondria.
0 to 300 mg
Tap to closeNicotinamide Riboside
Mitochondrial energyNicotinamide riboside chloride, a stabilised form of vitamin B3 naturally found in milk. Direct precursor to NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme present in every cell and involved in energy metabolism. Unlike conventional nicotinamide or nicotinic acid, nicotinamide riboside uses the nucleotide salvage pathway, a more direct metabolic route to NAD+. The chloride form ensures optimal stability at ambient temperature. Quality: non-GMO.
Form of vitamin B3 identified in milk and certain foods. Nicotinamide riboside is a direct precursor of NAD+ (nicotinamide adenine dinucleotide) via the nucleotide salvage pathway. NAD+ is a coenzyme present in every living cell, involved in hundreds of metabolic reactions. It plays a dual fundamental role: coenzyme in energy metabolism (glycolysis, Krebs cycle, mitochondrial respiratory chain) and substrate consumed by DNA repair and cellular maintenance enzymes. NAD+ levels decline by 40 to 60% between ages 40 and 60, a decline correlated with many aspects of biological aging. NR is the NAD+ precursor form with the best characterized human pharmacokinetics: clinical trials confirm a biochemical elevation of blood and tissue NAD+. Long-term functional benefits are the subject of ongoing studies in larger populations. In the formula, NR pairs with PQQ (also present), which supports mitochondrial renewal. These two compounds act complementarily: NR fuels energy production via NAD+, while PQQ promotes the genesis of new mitochondria.
0 to 300 mg
Omega-3 (EPA+DHA)
Systemic inflammationOmega-3 fatty acid lysine salt (EPA and DHA) derived from purified fish oil (anchovy, mackerel, herring). AvailOm technology: free fatty acids EPA and DHA are bonded to L-lysine, an essential amino acid obtained by fermentation. This ionic bond converts lipophilic omega-3s into a water-soluble, dispersible form, significantly improving intestinal absorption compared to classic forms (triglycerides, ethyl esters). Manufactured in France by Evonik Rexim (ISO 22000 and FSSC 22000 certified site). Strict marine contaminant control: dioxins, PCBs, heavy metals and aromatic hydrocarbons tested compliant with European regulatory thresholds. Contains fish. Quality: non-GMO, Halal certified.
EPA and DHA contribute to normal heart function (effect obtained with 250 mg/day). DHA contributes to normal brain function and maintenance of normal vision (effect obtained with 250 mg/day of DHA). The formula uses a free fatty acid technology bound to L-lysine, a water-soluble form derived from small wild fish (anchovy, mackerel, herring). This lysine binding transforms omega-3s, naturally water-insoluble, into a form with significantly improved intestinal absorption compared to classic forms (triglycerides, ethyl esters). DHA represents approximately 40% of polyunsaturated fatty acids in the brain and 60% in the retina, explaining its critical structural role in these high metabolic activity tissues. EPA is the precursor of resolvins and protectins, lipid mediators involved in inflammation resolution. Strict contaminant control (dioxins, PCBs, heavy metals) guarantees raw material purity, an essential criterion for prolonged daily supplementation.
0 to 2 g
Tap to closeOmega-3 (EPA+DHA)
Systemic inflammationOmega-3 fatty acid lysine salt (EPA and DHA) derived from purified fish oil (anchovy, mackerel, herring). AvailOm technology: free fatty acids EPA and DHA are bonded to L-lysine, an essential amino acid obtained by fermentation. This ionic bond converts lipophilic omega-3s into a water-soluble, dispersible form, significantly improving intestinal absorption compared to classic forms (triglycerides, ethyl esters). Manufactured in France by Evonik Rexim (ISO 22000 and FSSC 22000 certified site). Strict marine contaminant control: dioxins, PCBs, heavy metals and aromatic hydrocarbons tested compliant with European regulatory thresholds. Contains fish. Quality: non-GMO, Halal certified.
EPA and DHA contribute to normal heart function (effect obtained with 250 mg/day). DHA contributes to normal brain function and maintenance of normal vision (effect obtained with 250 mg/day of DHA). The formula uses a free fatty acid technology bound to L-lysine, a water-soluble form derived from small wild fish (anchovy, mackerel, herring). This lysine binding transforms omega-3s, naturally water-insoluble, into a form with significantly improved intestinal absorption compared to classic forms (triglycerides, ethyl esters). DHA represents approximately 40% of polyunsaturated fatty acids in the brain and 60% in the retina, explaining its critical structural role in these high metabolic activity tissues. EPA is the precursor of resolvins and protectins, lipid mediators involved in inflammation resolution. Strict contaminant control (dioxins, PCBs, heavy metals) guarantees raw material purity, an essential criterion for prolonged daily supplementation.
0 to 2 g
PQQ
Mitochondrial energyPyrroloquinoline quinone in disodium dihydrate form, produced by bacterial fermentation. PQQ is a redox cofactor with a tricyclic aromatic structure, naturally present in trace amounts in certain foods (kiwi, parsley, green tea, breast milk). The disodium form ensures optimal stability and solubility for oral absorption. PQQ is the subject of over 400 scientific publications. Quality: non-GMO.
Redox cofactor discovered in 1979 and characterized as a new class of coenzyme in 2003. Pyrroloquinoline quinone is naturally present in kiwi, parsley, green tea and breast milk, generally in minute quantities (nanograms per gram). It is one of the few redox cofactors identified since the last vitamin was discovered. PQQ stands out for its exceptional stability: it can perform thousands of redox cycles without degradation, whereas other antioxidants such as vitamin C are consumed after a single cycle. Research is particularly interested in its role in mitochondrial biogenesis, the process by which cells generate new mitochondria. The number and quality of mitochondria decline with age, a process that directly contributes to the loss of cellular energy. In the formula, PQQ forms a complementary duo with nicotinamide riboside (NR): NR fuels the NAD+ pathway for energy production in existing mitochondria, while PQQ supports the renewal of the mitochondrial pool itself. This complementarity between energy production and renewal of the energy infrastructure reflects an integrated approach to cellular metabolism.
0 to 20 mg
Tap to closePQQ
Mitochondrial energyPyrroloquinoline quinone in disodium dihydrate form, produced by bacterial fermentation. PQQ is a redox cofactor with a tricyclic aromatic structure, naturally present in trace amounts in certain foods (kiwi, parsley, green tea, breast milk). The disodium form ensures optimal stability and solubility for oral absorption. PQQ is the subject of over 400 scientific publications. Quality: non-GMO.
Redox cofactor discovered in 1979 and characterized as a new class of coenzyme in 2003. Pyrroloquinoline quinone is naturally present in kiwi, parsley, green tea and breast milk, generally in minute quantities (nanograms per gram). It is one of the few redox cofactors identified since the last vitamin was discovered. PQQ stands out for its exceptional stability: it can perform thousands of redox cycles without degradation, whereas other antioxidants such as vitamin C are consumed after a single cycle. Research is particularly interested in its role in mitochondrial biogenesis, the process by which cells generate new mitochondria. The number and quality of mitochondria decline with age, a process that directly contributes to the loss of cellular energy. In the formula, PQQ forms a complementary duo with nicotinamide riboside (NR): NR fuels the NAD+ pathway for energy production in existing mitochondria, while PQQ supports the renewal of the mitochondrial pool itself. This complementarity between energy production and renewal of the energy infrastructure reflects an integrated approach to cellular metabolism.
0 to 20 mg
Reishi
ImmunosenescenceDual extract from the fruiting body of reishi (Ganoderma lucidum), a functional mushroom called 'lingzhi' in traditional Chinese medicine for over 2,000 years. Dual extraction combines aqueous and ethanolic processes. Aqueous extraction concentrates polysaccharides (beta-glucans), soluble fibres with a branched structure. Ethanolic extraction concentrates triterpenes (ganoderic acids), lipophilic compounds specific to reishi. The 30:1 to 36:1 extraction ratio means 30 to 36 kg of fruiting body are required to yield 1 kg of extract. Most common extracts on the market offer only simple aqueous extraction, without triterpenes. Quality: non-GMO, pesticide-free.
Mushroom (Ganoderma lucidum) emblematic of the Chinese herbal tradition for over 2,000 years, where it is known as 'lingzhi.' Its unique composition is characterized by a dual richness: triterpenes (ganoderic acids, over 150 oxygenated compounds exclusive to the Ganoderma genus) and polysaccharides (beta-glucans with beta-1,3/1,6 structure). With over 4,000 referenced scientific publications, reishi is one of the most documented functional mushrooms in the world. Ganoderic acids constitute a molecular diversity without equivalent in the fungal kingdom. Traditionally associated with calm and serenity, reishi is described as an adaptogen, a substance that helps the body modulate its stress response. In the formula, it forms a complementary duo with maitake (also present): reishi primarily contributes its triterpenes, while maitake enriches the spectrum with its D-fraction beta-glucans. The dual standardized extract (water and ethanol) allows for the extraction of both water-soluble polysaccharides and lipid-soluble triterpenes, thus preserving the mushroom's full richness.
0 to 1.5 g
Tap to closeReishi
ImmunosenescenceDual extract from the fruiting body of reishi (Ganoderma lucidum), a functional mushroom called 'lingzhi' in traditional Chinese medicine for over 2,000 years. Dual extraction combines aqueous and ethanolic processes. Aqueous extraction concentrates polysaccharides (beta-glucans), soluble fibres with a branched structure. Ethanolic extraction concentrates triterpenes (ganoderic acids), lipophilic compounds specific to reishi. The 30:1 to 36:1 extraction ratio means 30 to 36 kg of fruiting body are required to yield 1 kg of extract. Most common extracts on the market offer only simple aqueous extraction, without triterpenes. Quality: non-GMO, pesticide-free.
Mushroom (Ganoderma lucidum) emblematic of the Chinese herbal tradition for over 2,000 years, where it is known as 'lingzhi.' Its unique composition is characterized by a dual richness: triterpenes (ganoderic acids, over 150 oxygenated compounds exclusive to the Ganoderma genus) and polysaccharides (beta-glucans with beta-1,3/1,6 structure). With over 4,000 referenced scientific publications, reishi is one of the most documented functional mushrooms in the world. Ganoderic acids constitute a molecular diversity without equivalent in the fungal kingdom. Traditionally associated with calm and serenity, reishi is described as an adaptogen, a substance that helps the body modulate its stress response. In the formula, it forms a complementary duo with maitake (also present): reishi primarily contributes its triterpenes, while maitake enriches the spectrum with its D-fraction beta-glucans. The dual standardized extract (water and ethanol) allows for the extraction of both water-soluble polysaccharides and lipid-soluble triterpenes, thus preserving the mushroom's full richness.
0 to 1.5 g
Rutin
Systemic inflammationRutin extracted from Sophora japonica flowers (pagoda tree), using ethanol-water extraction with an approximate 7:1 ratio. Rutin is a flavonoid glycoside: it combines quercetin, a flavonol, with a disaccharide (rutinose). This natural glycosylation improves quercetin's solubility and stability in the digestive environment. Unlike free quercetin, rutin withstands gastric degradation and is progressively hydrolysed in the intestine. Historically designated 'vitamin P' for its properties related to vascular permeability. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
Glycoside flavonoid of the flavonol family, rutin is one of the most widespread polyphenols in the plant kingdom. Naturally abundant in buckwheat, citrus fruits, capers and green tea, it takes its name from rue (Ruta graveolens), the plant in which it was first identified. Rutin stands out among flavonoids for its rutinoside group (glucose-rhamnose disaccharide), which gives it superior water solubility and specific absorption kinetics. In the intestine, bacterial glycosidases progressively release quercetin (the active aglycone), ensuring sustained release into the circulation rather than a brief plasma peak. This sustained-release mechanism represents a concrete pharmacokinetic advantage over free quercetin, which is rapidly metabolized. Rutin has a long history of use in European phytotherapy for its affinity with the vascular wall. It contributes to the maintenance of normal capillary permeability and blood vessel resistance, two parameters whose progressive deterioration accompanies vascular aging.
0 to 500 mg
Tap to closeRutin
Systemic inflammationRutin extracted from Sophora japonica flowers (pagoda tree), using ethanol-water extraction with an approximate 7:1 ratio. Rutin is a flavonoid glycoside: it combines quercetin, a flavonol, with a disaccharide (rutinose). This natural glycosylation improves quercetin's solubility and stability in the digestive environment. Unlike free quercetin, rutin withstands gastric degradation and is progressively hydrolysed in the intestine. Historically designated 'vitamin P' for its properties related to vascular permeability. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
Glycoside flavonoid of the flavonol family, rutin is one of the most widespread polyphenols in the plant kingdom. Naturally abundant in buckwheat, citrus fruits, capers and green tea, it takes its name from rue (Ruta graveolens), the plant in which it was first identified. Rutin stands out among flavonoids for its rutinoside group (glucose-rhamnose disaccharide), which gives it superior water solubility and specific absorption kinetics. In the intestine, bacterial glycosidases progressively release quercetin (the active aglycone), ensuring sustained release into the circulation rather than a brief plasma peak. This sustained-release mechanism represents a concrete pharmacokinetic advantage over free quercetin, which is rapidly metabolized. Rutin has a long history of use in European phytotherapy for its affinity with the vascular wall. It contributes to the maintenance of normal capillary permeability and blood vessel resistance, two parameters whose progressive deterioration accompanies vascular aging.
0 to 500 mg
Selenium
Oxidative stressL-selenomethionine, an organic form of selenium where the selenium atom replaces sulphur in methionine, an essential amino acid. This form exactly replicates the selenium naturally present in food (cereals, Brazil nuts, legumes). Unlike inorganic forms (selenite, selenate), selenomethionine is recognised by intestinal amino acid transporters, providing significantly higher oral bioavailability. Selenium contributes to the normal function of the immune system and to the protection of cells from oxidative stress. Quality: vegan, non-GMO, allergen-free.
Selenium contributes to the protection of cells against oxidative stress, to the normal functioning of the immune system, to normal thyroid function and to the maintenance of normal hair and nails. The human genome encodes 25 selenoproteins, including glutathione peroxidases (enzymes that neutralize hydrogen peroxide and lipid hydroperoxides) and thioredoxin reductases, involved in regenerating intracellular antioxidant systems. In selenomethionine form, selenium is non-specifically incorporated into body proteins in place of methionine, creating a reservoir mobilizable according to the body's needs. Selenium content in European soils is generally lower than in North American soils, resulting in variable dietary intakes across regions. The deiodinases, enzymes responsible for converting thyroxine (T4) to triiodothyronine (T3, the active form), are themselves selenoproteins. Selenium and iodine (also present in the formula) therefore work in tandem to support normal thyroid function.
0 to 150 µg
Tap to closeSelenium
Oxidative stressL-selenomethionine, an organic form of selenium where the selenium atom replaces sulphur in methionine, an essential amino acid. This form exactly replicates the selenium naturally present in food (cereals, Brazil nuts, legumes). Unlike inorganic forms (selenite, selenate), selenomethionine is recognised by intestinal amino acid transporters, providing significantly higher oral bioavailability. Selenium contributes to the normal function of the immune system and to the protection of cells from oxidative stress. Quality: vegan, non-GMO, allergen-free.
Selenium contributes to the protection of cells against oxidative stress, to the normal functioning of the immune system, to normal thyroid function and to the maintenance of normal hair and nails. The human genome encodes 25 selenoproteins, including glutathione peroxidases (enzymes that neutralize hydrogen peroxide and lipid hydroperoxides) and thioredoxin reductases, involved in regenerating intracellular antioxidant systems. In selenomethionine form, selenium is non-specifically incorporated into body proteins in place of methionine, creating a reservoir mobilizable according to the body's needs. Selenium content in European soils is generally lower than in North American soils, resulting in variable dietary intakes across regions. The deiodinases, enzymes responsible for converting thyroxine (T4) to triiodothyronine (T3, the active form), are themselves selenoproteins. Selenium and iodine (also present in the formula) therefore work in tandem to support normal thyroid function.
0 to 150 µg
Sulforaphane
Autophagy & SenescenceConcentrated extract from broccoli sprouts (Brassica oleracea var. italica), obtained by water-ethanol extraction with an approximate 15:1 ratio. Sulforaphane is a natural isothiocyanate formed in cruciferous vegetables during cell disruption, through enzymatic hydrolysis of glucoraphanin. Sprouts contain significantly higher glucoraphanin concentrations than mature broccoli. Standardised extraction ensures a stable level of active sulforaphane, unlike direct broccoli consumption where content varies with cooking, freshness and variety. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
Sulfur-containing isothiocyanate naturally present in cruciferous vegetables, particularly germinated broccoli seeds, where its concentration is 20 to 100 times higher than in mature broccoli. Sulforaphane is formed by the action of the enzyme myrosinase on glucoraphanin during chewing or processing. With over 3,000 scientific publications, it is one of the most studied plant compounds of the past decade. Sulforaphane stimulates the expression of over 200 cytoprotective genes, including those encoding phase II detoxification enzymes and endogenous antioxidant enzymes. This mechanism falls under hormesis: a mild molecular stress that activates cellular defenses disproportionately to the initial signal. The body responds by durably strengthening its detoxification and protective capacities. Clinical trials in humans have confirmed a measurable increase in detoxification enzyme activity following supplementation. The extract used is standardized in stabilized glucoraphanin, the inactive precursor that converts to sulforaphane in the intestine, ensuring controlled release in the digestive tract.
0 to 40 mg
Tap to closeSulforaphane
Autophagy & SenescenceConcentrated extract from broccoli sprouts (Brassica oleracea var. italica), obtained by water-ethanol extraction with an approximate 15:1 ratio. Sulforaphane is a natural isothiocyanate formed in cruciferous vegetables during cell disruption, through enzymatic hydrolysis of glucoraphanin. Sprouts contain significantly higher glucoraphanin concentrations than mature broccoli. Standardised extraction ensures a stable level of active sulforaphane, unlike direct broccoli consumption where content varies with cooking, freshness and variety. Quality: vegan, non-GMO, pesticide-free, no excipient, preservative-free, Halal and Kosher certified.
Sulfur-containing isothiocyanate naturally present in cruciferous vegetables, particularly germinated broccoli seeds, where its concentration is 20 to 100 times higher than in mature broccoli. Sulforaphane is formed by the action of the enzyme myrosinase on glucoraphanin during chewing or processing. With over 3,000 scientific publications, it is one of the most studied plant compounds of the past decade. Sulforaphane stimulates the expression of over 200 cytoprotective genes, including those encoding phase II detoxification enzymes and endogenous antioxidant enzymes. This mechanism falls under hormesis: a mild molecular stress that activates cellular defenses disproportionately to the initial signal. The body responds by durably strengthening its detoxification and protective capacities. Clinical trials in humans have confirmed a measurable increase in detoxification enzyme activity following supplementation. The extract used is standardized in stabilized glucoraphanin, the inactive precursor that converts to sulforaphane in the intestine, ensuring controlled release in the digestive tract.
0 to 40 mg
Taurine
Mitochondrial energyVegan-certified synthetic taurine, a non-proteinogenic sulphur amino acid. Unlike the 20 protein amino acids, taurine is not incorporated into proteins: it remains free in tissues. It naturally concentrates in the heart, brain, retina and skeletal muscles. The body synthesises it from cysteine, but this endogenous synthesis may be insufficient depending on individual nutritional profiles. The vegan form, obtained by chemical synthesis without animal-derived raw materials, is chemically identical to natural taurine. Quality: vegan, non-GMO.
Often mistaken for a stimulant because of its presence in energy drinks, taurine is actually a sulfur amino acid with calming properties that acts as an inhibitory neuromodulator in the central nervous system. It is one of the most abundant free amino acids in the human body (50 to 70 g in adults), concentrated in organs with high metabolic demand: heart, brain, retina and skeletal muscles. A major study published in Science in 2023 highlighted a correlation between declining taurine levels and many markers of biological aging, sparking considerable renewed interest in this long-underestimated molecule. Tissue concentrations decline markedly after age 50, making supplementation particularly relevant from a longevity perspective. Taurine acts as a cellular osmoregulator, stabilizes membranes, participates in bile acid conjugation necessary for fat absorption, and modulates calcium influx in cardiomyocytes. Synthesized in the body from cysteine, it works in synergy with NAC (N-acetylcysteine, also present in the formula), which provides precisely this precursor.
0 to 2 g
Tap to closeTaurine
Mitochondrial energyVegan-certified synthetic taurine, a non-proteinogenic sulphur amino acid. Unlike the 20 protein amino acids, taurine is not incorporated into proteins: it remains free in tissues. It naturally concentrates in the heart, brain, retina and skeletal muscles. The body synthesises it from cysteine, but this endogenous synthesis may be insufficient depending on individual nutritional profiles. The vegan form, obtained by chemical synthesis without animal-derived raw materials, is chemically identical to natural taurine. Quality: vegan, non-GMO.
Often mistaken for a stimulant because of its presence in energy drinks, taurine is actually a sulfur amino acid with calming properties that acts as an inhibitory neuromodulator in the central nervous system. It is one of the most abundant free amino acids in the human body (50 to 70 g in adults), concentrated in organs with high metabolic demand: heart, brain, retina and skeletal muscles. A major study published in Science in 2023 highlighted a correlation between declining taurine levels and many markers of biological aging, sparking considerable renewed interest in this long-underestimated molecule. Tissue concentrations decline markedly after age 50, making supplementation particularly relevant from a longevity perspective. Taurine acts as a cellular osmoregulator, stabilizes membranes, participates in bile acid conjugation necessary for fat absorption, and modulates calcium influx in cardiomyocytes. Synthesized in the body from cysteine, it works in synergy with NAC (N-acetylcysteine, also present in the formula), which provides precisely this precursor.
0 to 2 g
Trehalose
Autophagy & SenescenceTrehalose dihydrate, a non-reducing disaccharide composed of two glucose molecules linked by an alpha-1,1 bond. Naturally found in mushrooms, yeast and certain extremophile organisms. Unlike sucrose, its symmetrical bond provides remarkable stability against heat and acidity. Trehalose protects protein and lipid structures during desiccation, a well-documented mechanism in cell biology. Its sweetening power is approximately 45% that of sucrose. Quality: non-GMO, no excipient.
Non-reducing disaccharide composed of two glucose molecules linked in alpha,alpha-1,1. Present in mushrooms, yeasts and certain organisms capable of surviving near-total dehydration: tardigrades and so-called 'resurrection plants.' It is precisely this molecular stabilization property under extreme conditions that distinguishes trehalose from other sugars. During dehydration, trehalose forms a vitreous matrix around proteins and lipid membranes, replacing water molecules in hydrogen bond interactions and preserving the native three-dimensional conformation of biomolecules. This unique capacity for biological vitrification is exploited in biotechnology to stabilize vaccines, enzymes and therapeutic proteins without a cold chain. In the context of longevity, trehalose is studied for its ability to promote cellular autophagy, the process by which the cell eliminates its damaged or dysfunctional components. This fundamental maintenance mechanism naturally declines with age, contributing to the accumulation of cellular debris and progressive tissue dysfunction.
0 to 6 g
Tap to closeTrehalose
Autophagy & SenescenceTrehalose dihydrate, a non-reducing disaccharide composed of two glucose molecules linked by an alpha-1,1 bond. Naturally found in mushrooms, yeast and certain extremophile organisms. Unlike sucrose, its symmetrical bond provides remarkable stability against heat and acidity. Trehalose protects protein and lipid structures during desiccation, a well-documented mechanism in cell biology. Its sweetening power is approximately 45% that of sucrose. Quality: non-GMO, no excipient.
Non-reducing disaccharide composed of two glucose molecules linked in alpha,alpha-1,1. Present in mushrooms, yeasts and certain organisms capable of surviving near-total dehydration: tardigrades and so-called 'resurrection plants.' It is precisely this molecular stabilization property under extreme conditions that distinguishes trehalose from other sugars. During dehydration, trehalose forms a vitreous matrix around proteins and lipid membranes, replacing water molecules in hydrogen bond interactions and preserving the native three-dimensional conformation of biomolecules. This unique capacity for biological vitrification is exploited in biotechnology to stabilize vaccines, enzymes and therapeutic proteins without a cold chain. In the context of longevity, trehalose is studied for its ability to promote cellular autophagy, the process by which the cell eliminates its damaged or dysfunctional components. This fundamental maintenance mechanism naturally declines with age, contributing to the accumulation of cellular debris and progressive tissue dysfunction.
0 to 6 g
Trimethylglycine
Genomic stabilityAnhydrous betaine, derived from glycine carrying three methyl groups. Naturally found in beetroot, spinach and quinoa. The anhydrous form (free of crystallisation water) concentrates more active substance per gram than hydrated betaine. This molecule is a methyl group donor, essential to the methionine cycle and homocysteine homeostasis. Quality: vegan, non-GMO, no excipient.
Betaine (trimethylglycine) contributes to normal homocysteine metabolism (effect obtained with a daily intake of 1.5 g). Naturally present in beetroot, which gave it its name (Beta vulgaris), spinach and quinoa. TMG carries three methyl groups on its structure, making it one of the most concentrated methyl donors in the food kingdom. Methylation is a fundamental biochemical process: thousands of methylation reactions occur every second in the body, affecting gene expression (epigenetics), neurotransmitter synthesis, hepatic detoxification and creatine metabolism. Homocysteine is metabolized through two pathways: remethylation (dependent on vitamins B9 and B12) and transsulfuration (dependent on vitamin B6). TMG opens an alternative remethylation pathway via the enzyme BHMT in the liver, independent of folate. In the formula, TMG works in synergy with vitamin B12 (methylcobalamin), vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), thereby covering the entire methylation cycle through complementary pathways. Note: a daily intake exceeding 4 g may increase blood cholesterol levels.
0 to 400 mg
Tap to closeTrimethylglycine
Genomic stabilityAnhydrous betaine, derived from glycine carrying three methyl groups. Naturally found in beetroot, spinach and quinoa. The anhydrous form (free of crystallisation water) concentrates more active substance per gram than hydrated betaine. This molecule is a methyl group donor, essential to the methionine cycle and homocysteine homeostasis. Quality: vegan, non-GMO, no excipient.
Betaine (trimethylglycine) contributes to normal homocysteine metabolism (effect obtained with a daily intake of 1.5 g). Naturally present in beetroot, which gave it its name (Beta vulgaris), spinach and quinoa. TMG carries three methyl groups on its structure, making it one of the most concentrated methyl donors in the food kingdom. Methylation is a fundamental biochemical process: thousands of methylation reactions occur every second in the body, affecting gene expression (epigenetics), neurotransmitter synthesis, hepatic detoxification and creatine metabolism. Homocysteine is metabolized through two pathways: remethylation (dependent on vitamins B9 and B12) and transsulfuration (dependent on vitamin B6). TMG opens an alternative remethylation pathway via the enzyme BHMT in the liver, independent of folate. In the formula, TMG works in synergy with vitamin B12 (methylcobalamin), vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), thereby covering the entire methylation cycle through complementary pathways. Note: a daily intake exceeding 4 g may increase blood cholesterol levels.
0 to 400 mg
Vitamin B12
Genomic stabilityVitamin B12 as methylcobalamin, a coenzyme naturally present in the body. Unlike cyanocobalamin (the classic synthetic form), methylcobalamin requires no hepatic conversion to become active. It participates directly in the methionine cycle and homocysteine metabolism. Vitamin B12 contributes to normal energy-yielding metabolism, normal red blood cell formation and normal nervous system function. Quality: vegan, non-GMO.
Vitamin B12 contributes to normal energy metabolism, to the normal functioning of the nervous system, to normal homocysteine metabolism, to normal psychological functions, to normal red blood cell formation and to the reduction of tiredness and fatigue. A unique vitamin among all: it contains cobalt in its corrin ring, is exclusively synthesized by microorganisms, and its absorption requires a complex mechanism involving gastric intrinsic factor. The prevalence of B12 insufficiency increases significantly with age, affecting up to 20% of people over 60, due to the progressive decrease in gastric acid and intrinsic factor production. Vegan diets imperatively require supplementation. In the formula, B12 participates in the methylation cycle alongside TMG, vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), together ensuring efficient remethylation of homocysteine to methionine. The methylcobalamin form selected is one of the two active coenzyme forms of B12: the one the body uses directly in the cellular cytoplasm, without prior hepatic conversion.
0 to 1,500 µg
Tap to closeVitamin B12
Genomic stabilityVitamin B12 as methylcobalamin, a coenzyme naturally present in the body. Unlike cyanocobalamin (the classic synthetic form), methylcobalamin requires no hepatic conversion to become active. It participates directly in the methionine cycle and homocysteine metabolism. Vitamin B12 contributes to normal energy-yielding metabolism, normal red blood cell formation and normal nervous system function. Quality: vegan, non-GMO.
Vitamin B12 contributes to normal energy metabolism, to the normal functioning of the nervous system, to normal homocysteine metabolism, to normal psychological functions, to normal red blood cell formation and to the reduction of tiredness and fatigue. A unique vitamin among all: it contains cobalt in its corrin ring, is exclusively synthesized by microorganisms, and its absorption requires a complex mechanism involving gastric intrinsic factor. The prevalence of B12 insufficiency increases significantly with age, affecting up to 20% of people over 60, due to the progressive decrease in gastric acid and intrinsic factor production. Vegan diets imperatively require supplementation. In the formula, B12 participates in the methylation cycle alongside TMG, vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), together ensuring efficient remethylation of homocysteine to methionine. The methylcobalamin form selected is one of the two active coenzyme forms of B12: the one the body uses directly in the cellular cytoplasm, without prior hepatic conversion.
0 to 1,500 µg
Vitamin B6 (P5P)
Genomic stabilityActive form of vitamin B6: pyridoxal-5-phosphate (P5P) monohydrate. Unlike classic forms (pyridoxine, pyridoxamine), P5P is directly usable by the body without prior hepatic conversion. This conversion step can be limiting in certain individuals. P5P serves as a coenzyme in over 150 enzymatic reactions, particularly in amino acid metabolism and neurotransmitter synthesis. Vitamin B6 contributes to normal nervous system function and to the reduction of tiredness and fatigue. Quality: non-GMO, no excipient.
Vitamin B6 contributes to normal energy metabolism, to the normal functioning of the nervous system, to normal psychological functions, to the reduction of tiredness and fatigue, to normal protein and glycogen metabolism and to the regulation of hormonal activity. Cofactor of over 150 enzymatic reactions, B6 is primarily involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA, noradrenaline) and hemoglobin synthesis. It also participates in the conversion of tryptophan to niacin (vitamin B3). In the methylation cycle, B6 is the cofactor of the transsulfuration pathway of homocysteine, complementary to the remethylation pathway supported by TMG, vitamin B12 and vitamin B9 (all present in the formula). This coverage of both metabolic pathways of homocysteine is a deliberate formulation choice. The P-5-P (pyridoxal-5-phosphate) form selected is the directly active form, usable by the body without prior hepatic conversion. Conventional forms (pyridoxine, pyridoxamine) must be converted to P-5-P by the liver, a step that may be limited in some individuals with genetic polymorphisms of conversion enzymes.
0 to 19 mg
Tap to closeVitamin B6 (P5P)
Genomic stabilityActive form of vitamin B6: pyridoxal-5-phosphate (P5P) monohydrate. Unlike classic forms (pyridoxine, pyridoxamine), P5P is directly usable by the body without prior hepatic conversion. This conversion step can be limiting in certain individuals. P5P serves as a coenzyme in over 150 enzymatic reactions, particularly in amino acid metabolism and neurotransmitter synthesis. Vitamin B6 contributes to normal nervous system function and to the reduction of tiredness and fatigue. Quality: non-GMO, no excipient.
Vitamin B6 contributes to normal energy metabolism, to the normal functioning of the nervous system, to normal psychological functions, to the reduction of tiredness and fatigue, to normal protein and glycogen metabolism and to the regulation of hormonal activity. Cofactor of over 150 enzymatic reactions, B6 is primarily involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA, noradrenaline) and hemoglobin synthesis. It also participates in the conversion of tryptophan to niacin (vitamin B3). In the methylation cycle, B6 is the cofactor of the transsulfuration pathway of homocysteine, complementary to the remethylation pathway supported by TMG, vitamin B12 and vitamin B9 (all present in the formula). This coverage of both metabolic pathways of homocysteine is a deliberate formulation choice. The P-5-P (pyridoxal-5-phosphate) form selected is the directly active form, usable by the body without prior hepatic conversion. Conventional forms (pyridoxine, pyridoxamine) must be converted to P-5-P by the liver, a step that may be limited in some individuals with genetic polymorphisms of conversion enzymes.
0 to 19 mg
Vitamin B9
Genomic stabilityVitamin B9 as calcium L-5-methyltetrahydrofolate (5-MTHF), stabilised crystalline form. 5-MTHF is the biologically active form of folate, directly usable by the body. Unlike synthetic folic acid, it requires no enzymatic reduction by MTHFR (methylenetetrahydrofolate reductase), an enzyme whose activity is reduced in a significant portion of the population due to common genetic polymorphisms. Folate contributes to maternal tissue growth during pregnancy and to normal immune system function. Quality: non-GMO.
Folates contribute to normal blood formation, to normal homocysteine metabolism, to normal psychological functions, to the normal functioning of the immune system and play a role in the process of cell division. Essential for DNA synthesis and methylation, folates are particularly active in rapidly renewing tissues: bone marrow, intestinal mucosa, and during embryonic development. Synthetic folic acid must be converted to 5-MTHF by the enzyme MTHFR before it can perform its biological functions. However, approximately 10% of the European population carries the MTHFR C677T polymorphism in homozygous state, reducing the activity of this enzyme by 70%. This genetic limitation can compromise the effectiveness of conventional folic acid. The 5-MTHF (active folate) form selected in the formula completely bypasses this issue: it is the predominant circulating form in human plasma, directly usable without depending on individual conversion capacity. In the methylation cycle, B9 works in synergy with vitamin B12 (methylcobalamin), TMG and vitamin B6 (P-5-P), also present in the formula, to ensure optimal remethylation of homocysteine.
0 to 500 µg
Tap to closeVitamin B9
Genomic stabilityVitamin B9 as calcium L-5-methyltetrahydrofolate (5-MTHF), stabilised crystalline form. 5-MTHF is the biologically active form of folate, directly usable by the body. Unlike synthetic folic acid, it requires no enzymatic reduction by MTHFR (methylenetetrahydrofolate reductase), an enzyme whose activity is reduced in a significant portion of the population due to common genetic polymorphisms. Folate contributes to maternal tissue growth during pregnancy and to normal immune system function. Quality: non-GMO.
Folates contribute to normal blood formation, to normal homocysteine metabolism, to normal psychological functions, to the normal functioning of the immune system and play a role in the process of cell division. Essential for DNA synthesis and methylation, folates are particularly active in rapidly renewing tissues: bone marrow, intestinal mucosa, and during embryonic development. Synthetic folic acid must be converted to 5-MTHF by the enzyme MTHFR before it can perform its biological functions. However, approximately 10% of the European population carries the MTHFR C677T polymorphism in homozygous state, reducing the activity of this enzyme by 70%. This genetic limitation can compromise the effectiveness of conventional folic acid. The 5-MTHF (active folate) form selected in the formula completely bypasses this issue: it is the predominant circulating form in human plasma, directly usable without depending on individual conversion capacity. In the methylation cycle, B9 works in synergy with vitamin B12 (methylcobalamin), TMG and vitamin B6 (P-5-P), also present in the formula, to ensure optimal remethylation of homocysteine.
0 to 500 µg
Vitamin C
Oxidative stressL-ascorbic acid coated with ethylcellulose, an inert food-grade polymer. This coating protects vitamin C from oxidation and moisture degradation, two major weaknesses of unprotected ascorbic acid. Ethylcellulose enables gradual release in the digestive tract, extending the intestinal absorption window. The human body does not synthesise vitamin C (unlike most mammals). It contributes to normal immune system function and to the protection of cells from oxidative stress. Quality: non-GMO.
Vitamin C contributes to the normal formation of collagen for the normal function of skin and blood vessels, to the protection of cells against oxidative stress, to the normal functioning of the immune system and increases iron absorption. Humans are one of the few mammals unable to synthesize vitamin C, a genetic peculiarity resulting from the mutation of the GULO gene approximately 60 million years ago. Vitamin C is an indispensable cofactor of prolyl hydroxylases and lysyl hydroxylases, the enzymes that catalyze the hydroxylation of proline and lysine in collagen. Without these modifications, the collagen triple helix cannot form correctly. In the formula, vitamin C works in concert with type I collagen, glycine and L-lysine to support complete collagen synthesis. It also facilitates non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract, a direct synergy with the iron bisglycinate present in the formula. Vitamin C also participates in the regeneration of oxidized vitamin E and in the biosynthesis of carnitine and noradrenaline.
0 to 1,000 mg
Tap to closeVitamin C
Oxidative stressL-ascorbic acid coated with ethylcellulose, an inert food-grade polymer. This coating protects vitamin C from oxidation and moisture degradation, two major weaknesses of unprotected ascorbic acid. Ethylcellulose enables gradual release in the digestive tract, extending the intestinal absorption window. The human body does not synthesise vitamin C (unlike most mammals). It contributes to normal immune system function and to the protection of cells from oxidative stress. Quality: non-GMO.
Vitamin C contributes to the normal formation of collagen for the normal function of skin and blood vessels, to the protection of cells against oxidative stress, to the normal functioning of the immune system and increases iron absorption. Humans are one of the few mammals unable to synthesize vitamin C, a genetic peculiarity resulting from the mutation of the GULO gene approximately 60 million years ago. Vitamin C is an indispensable cofactor of prolyl hydroxylases and lysyl hydroxylases, the enzymes that catalyze the hydroxylation of proline and lysine in collagen. Without these modifications, the collagen triple helix cannot form correctly. In the formula, vitamin C works in concert with type I collagen, glycine and L-lysine to support complete collagen synthesis. It also facilitates non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract, a direct synergy with the iron bisglycinate present in the formula. Vitamin C also participates in the regeneration of oxidized vitamin E and in the biosynthesis of carnitine and noradrenaline.
0 to 1,000 mg
Vitamin D3
Genomic stabilityPlant-sourced cholecalciferol (lichen), encapsulated in a protective matrix of acacia gum, modified starch and natural antioxidants (vitamin E, sodium ascorbate). This microencapsulation shields vitamin D3 from light and oxidation, ensuring optimal stability. The plant source (lichen) provides a certified vegan alternative to ovine lanolin, the classic cholecalciferol source. Vitamin D contributes to the maintenance of normal bones, normal immune system function and normal absorption of calcium. Quality: vegan, non-GMO.
Vitamin D contributes to the normal functioning of the immune system, to the maintenance of normal bones, normal teeth, normal muscle function and to the normal absorption of calcium and phosphorus. Vitamin D3 (cholecalciferol) is the form naturally produced by human skin under the effect of UVB rays. From October to March above the 35th parallel, the angle of solar incidence is too low to allow significant cutaneous synthesis, creating what researchers call 'vitamin D winter.' Vitamin D functions as a pro-hormone: once hydroxylated to calcitriol (1,25-dihydroxyvitamin D3) by the liver then the kidneys, it binds to the VDR (Vitamin D Receptor), a transcription factor expressed in over 30 cell types, regulating the expression of more than 1,000 genes involved in immunity, cell differentiation and phosphocalcic metabolism. D3 is part of the formula's bone axis, where it works in synergy with vitamin K2-MK7 (which directs calcium toward bones rather than arteries), magnesium (cofactor of vitamin D hydroxylation enzymes), boron and calcium alpha-ketoglutarate.
0 to 89 µg
Tap to closeVitamin D3
Genomic stabilityPlant-sourced cholecalciferol (lichen), encapsulated in a protective matrix of acacia gum, modified starch and natural antioxidants (vitamin E, sodium ascorbate). This microencapsulation shields vitamin D3 from light and oxidation, ensuring optimal stability. The plant source (lichen) provides a certified vegan alternative to ovine lanolin, the classic cholecalciferol source. Vitamin D contributes to the maintenance of normal bones, normal immune system function and normal absorption of calcium. Quality: vegan, non-GMO.
Vitamin D contributes to the normal functioning of the immune system, to the maintenance of normal bones, normal teeth, normal muscle function and to the normal absorption of calcium and phosphorus. Vitamin D3 (cholecalciferol) is the form naturally produced by human skin under the effect of UVB rays. From October to March above the 35th parallel, the angle of solar incidence is too low to allow significant cutaneous synthesis, creating what researchers call 'vitamin D winter.' Vitamin D functions as a pro-hormone: once hydroxylated to calcitriol (1,25-dihydroxyvitamin D3) by the liver then the kidneys, it binds to the VDR (Vitamin D Receptor), a transcription factor expressed in over 30 cell types, regulating the expression of more than 1,000 genes involved in immunity, cell differentiation and phosphocalcic metabolism. D3 is part of the formula's bone axis, where it works in synergy with vitamin K2-MK7 (which directs calcium toward bones rather than arteries), magnesium (cofactor of vitamin D hydroxylation enzymes), boron and calcium alpha-ketoglutarate.
0 to 89 µg
Vitamin K2-MK7
Tissue structureVitamin K2 as menaquinone-7 (MK-7), Pharmaquinone brand, all-trans isomer produced by fermentation. The all-trans isomer is the only biologically active form of MK-7. Unlike MK-4 forms (short half-life of a few hours), MK-7 has an extended half-life (approximately 72 hours), allowing stable blood levels with a single daily intake. Vitamin K contributes to the maintenance of normal bones and to normal blood clotting. Microcrystalline cellulose (MCC) carrier.
Vitamin K contributes to the maintenance of normal bones and to normal blood coagulation. Menaquinone-7 (MK-7) form, naturally produced by bacterial fermentation, the same process that gives Japanese natto its characteristic texture. MK-7 stands out from other forms of vitamin K by its long plasma half-life (approximately 72 hours versus 1 to 2 hours for K1), ensuring prolonged presence in the circulation and efficient distribution to extra-hepatic tissues, notably bones and blood vessels. Vitamin K2 activates two key proteins. In bones, osteocalcin binds calcium to the bone matrix. In blood vessels, MGP (Matrix Gla Protein) inhibits arterial calcification. This dual action directs calcium toward bones and away from arteries. K2-MK7 is an essential complement to vitamin D3 (also present in the formula), with which it shares the calcium metabolism axis. This same bone axis includes magnesium, boron and calcium alpha-ketoglutarate, forming a coherent network of cofactors working in concert to maintain bone health.
0 to 200 µg
Tap to closeVitamin K2-MK7
Tissue structureVitamin K2 as menaquinone-7 (MK-7), Pharmaquinone brand, all-trans isomer produced by fermentation. The all-trans isomer is the only biologically active form of MK-7. Unlike MK-4 forms (short half-life of a few hours), MK-7 has an extended half-life (approximately 72 hours), allowing stable blood levels with a single daily intake. Vitamin K contributes to the maintenance of normal bones and to normal blood clotting. Microcrystalline cellulose (MCC) carrier.
Vitamin K contributes to the maintenance of normal bones and to normal blood coagulation. Menaquinone-7 (MK-7) form, naturally produced by bacterial fermentation, the same process that gives Japanese natto its characteristic texture. MK-7 stands out from other forms of vitamin K by its long plasma half-life (approximately 72 hours versus 1 to 2 hours for K1), ensuring prolonged presence in the circulation and efficient distribution to extra-hepatic tissues, notably bones and blood vessels. Vitamin K2 activates two key proteins. In bones, osteocalcin binds calcium to the bone matrix. In blood vessels, MGP (Matrix Gla Protein) inhibits arterial calcification. This dual action directs calcium toward bones and away from arteries. K2-MK7 is an essential complement to vitamin D3 (also present in the formula), with which it shares the calcium metabolism axis. This same bone axis includes magnesium, boron and calcium alpha-ketoglutarate, forming a coherent network of cofactors working in concert to maintain bone health.
0 to 200 µg
Zeaxanthin
Oxidative stressMicroencapsulated zeaxanthin, a carotenoid extracted from Tagetes erecta flower (marigold) using water-ethanol solvent. Microencapsulation in a maltodextrin matrix protects this fat-soluble pigment from oxidation and light. Zeaxanthin concentrates in the centre of the macula (fovea), the retinal area responsible for fine vision. It works in complementarity with lutein, which distributes around the macula periphery. Quality: vegan, non-GMO, pesticide-free, Halal and Kosher certified.
Carotenoid isomer of lutein, extracted from marigold (Tagetes erecta). Zeaxanthin concentrates at the exact center of the macula (the fovea, the area of maximum cone density), where together with lutein it constitutes the macular pigment, the natural optical filter of the human eye. While lutein (also present in the formula) predominates at the periphery of the macula, zeaxanthin is the dominant carotenoid at the center of the fovea. This complementary distribution ensures complete macular pigment coverage. Zeaxanthin absorbs blue light photons with slightly greater efficiency than lutein in the 450-470 nm band, the most energetic of the visible spectrum. The body does not synthesize zeaxanthin: it must be provided through the diet (corn, yellow peppers, egg yolk) or supplementation. Zeaxanthin also shares membrane transport and incorporation mechanisms with astaxanthin (present in the formula), the three carotenoids forming a complementary photoprotection network at different tissue levels.
0 to 2 mg
Tap to closeZeaxanthin
Oxidative stressMicroencapsulated zeaxanthin, a carotenoid extracted from Tagetes erecta flower (marigold) using water-ethanol solvent. Microencapsulation in a maltodextrin matrix protects this fat-soluble pigment from oxidation and light. Zeaxanthin concentrates in the centre of the macula (fovea), the retinal area responsible for fine vision. It works in complementarity with lutein, which distributes around the macula periphery. Quality: vegan, non-GMO, pesticide-free, Halal and Kosher certified.
Carotenoid isomer of lutein, extracted from marigold (Tagetes erecta). Zeaxanthin concentrates at the exact center of the macula (the fovea, the area of maximum cone density), where together with lutein it constitutes the macular pigment, the natural optical filter of the human eye. While lutein (also present in the formula) predominates at the periphery of the macula, zeaxanthin is the dominant carotenoid at the center of the fovea. This complementary distribution ensures complete macular pigment coverage. Zeaxanthin absorbs blue light photons with slightly greater efficiency than lutein in the 450-470 nm band, the most energetic of the visible spectrum. The body does not synthesize zeaxanthin: it must be provided through the diet (corn, yellow peppers, egg yolk) or supplementation. Zeaxanthin also shares membrane transport and incorporation mechanisms with astaxanthin (present in the formula), the three carotenoids forming a complementary photoprotection network at different tissue levels.
0 to 2 mg
Zinc
Genomic stabilityZinc bisglycinate: each zinc atom is chelated (bonded) to two glycine molecules, the smallest amino acid naturally present in the body. This chelation forms a complex stable at gastric pH, which uses amino acid absorption pathways in the intestine. Result: superior bioavailability compared to classic inorganic forms (oxide, sulphate) and optimal digestive tolerance. Zinc contributes to normal immune system function and to the protection of cells from oxidative stress. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Zinc contributes to the normal functioning of the immune system, to normal DNA synthesis, to the protection of cells against oxidative stress, to the maintenance of normal vision, normal skin and normal bones. The second most abundant trace element in the body after iron, zinc has no significant storage reserve, making a regular daily intake essential. Structurally involved in over 300 enzymes and approximately 10% of all human proteins, zinc is ubiquitous in cellular biochemistry. 'Zinc fingers' are structural protein motifs that allow hundreds of transcription factors to bind to DNA and regulate gene expression. Zinc is also a structural component of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic antioxidant defense in the body. This enzyme works in tandem with copper (also present in the formula in bisglycinate form), both minerals being necessary for its catalytic activity. A zinc-copper-iron balance is maintained in the formula to optimize absorption without excessive competition between these minerals. The bisglycinate form selected offers optimal absorption through dipeptide transport.
0 to 15 mg
Tap to closeZinc
Genomic stabilityZinc bisglycinate: each zinc atom is chelated (bonded) to two glycine molecules, the smallest amino acid naturally present in the body. This chelation forms a complex stable at gastric pH, which uses amino acid absorption pathways in the intestine. Result: superior bioavailability compared to classic inorganic forms (oxide, sulphate) and optimal digestive tolerance. Zinc contributes to normal immune system function and to the protection of cells from oxidative stress. Quality: vegan, non-GMO, no excipient, Halal and Kosher certified.
Zinc contributes to the normal functioning of the immune system, to normal DNA synthesis, to the protection of cells against oxidative stress, to the maintenance of normal vision, normal skin and normal bones. The second most abundant trace element in the body after iron, zinc has no significant storage reserve, making a regular daily intake essential. Structurally involved in over 300 enzymes and approximately 10% of all human proteins, zinc is ubiquitous in cellular biochemistry. 'Zinc fingers' are structural protein motifs that allow hundreds of transcription factors to bind to DNA and regulate gene expression. Zinc is also a structural component of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic antioxidant defense in the body. This enzyme works in tandem with copper (also present in the formula in bisglycinate form), both minerals being necessary for its catalytic activity. A zinc-copper-iron balance is maintained in the formula to optimize absorption without excessive competition between these minerals. The bisglycinate form selected offers optimal absorption through dipeptide transport.
0 to 15 mg
Quality and traceability
Each bioactive is selected according to strict criteria of quality, purity and bioavailability.
Quality tests
Certificates of analysis available
Premium sources
Certified suppliers
FR manufacturing
In-house lab in France
Eco-responsible
Recyclable packaging
Methodology
Our bioactive selection is based on the most robust longevity studies, reviewed by a multidisciplinary body of independent experts (doctors, pharmacists, nutritionists). Out of 127 bioactives evaluated since inception, 74 have been rejected. This rigor ensures that every ingredient in your formula has scientifically proven its value.
Systematic review
Each bioactive is selected after analysis of meta-analyses and randomized scientific trials available on PubMed and Cochrane.
Bioavailable forms
We prioritize the most absorbable forms (methylcobalamin vs cyanocobalamin, citrate vs oxide) for maximum efficacy.
Evidence-based dosages
Dosages are based on scientific studies that have demonstrated efficacy, not minimum recommended daily intakes.
Verified interactions
Each combination is verified for synergies (e.g., D3+K2) and potential interactions to avoid.
The price of precision
The standard industry optimizes cost per capsule. Singular optimizes biological benefit per milligram absorbed. For instance:
| Bioactive | Generic form | Singular form | Cost diff | Benefit |
|---|---|---|---|---|
| Magnesium | Oxide | Bisglycinate | 8-12× | 4% → 80% absorption |
| Vitamin B12 | Cyanocobalamin | Methylcobalamin | 5× | Direct active form |
| Folate | Folic acid | 5-MTHF (Quatrefolic®) | 10-15× | Universally active form |
| Curcumin | Standard extract | Liposomal form | 6-8× | 185× bioavailability |
This systemic surcharge does not appear on your invoice. It is built into our quality commitment.