Our bioactives library
Each bioactive is selected for its benefit demonstrated in humans and its documented bioavailability.
Every dosage shown states the active substance itself, excluding excipients and carriers. The raw material weighed in the laboratory is always heavier than the figure displayed.
Astaxanthin
Red carotenoid pigment extracted from Haematococcus pluvialis microalgae, one of the most concentrated natural sources of astaxanthin. This encapsulated form is water-dispersible: astaxanthin, fat-soluble in its natural state, is carried by a modified corn starch matrix that allows homogeneous dispersion in aqueous media. To date, no published human study compares the absorption of this form with that of the oils and oleoresins used in the trials. A blend of natural tocopherols protects the pigment from oxidation within this matrix. Unlike synthetic astaxanthin derived from petrochemistry, this form comes from controlled microalgal cultivation. The guaranteed assay covers total free astaxanthin, the sum of its isomers. The all-trans isomer is predominant at batch control.
Carotenoid of the xanthophyll family, astaxanthin is the pigment responsible for the red color of salmon, shrimp and flamingos. Extracted from the microalga Haematococcus pluvialis, its unique molecular structure allows it to span the lipid bilayer of cell membranes from end to end, a property shared by neither beta-carotene nor vitamin E. Unlike other carotenoids, astaxanthin does not convert to vitamin A, eliminating any risk of hypervitaminosis A even at high doses. In the formula, it complements lutein and zeaxanthin (also present) to form a trio of carotenoids with complementary localizations: astaxanthin in cell membranes, lutein at the periphery of the macula, zeaxanthin at the center of the macular pigment.
0 to 6 mg
Tap to closeAstaxanthin
Red carotenoid pigment extracted from Haematococcus pluvialis microalgae, one of the most concentrated natural sources of astaxanthin. This encapsulated form is water-dispersible: astaxanthin, fat-soluble in its natural state, is carried by a modified corn starch matrix that allows homogeneous dispersion in aqueous media. To date, no published human study compares the absorption of this form with that of the oils and oleoresins used in the trials. A blend of natural tocopherols protects the pigment from oxidation within this matrix. Unlike synthetic astaxanthin derived from petrochemistry, this form comes from controlled microalgal cultivation. The guaranteed assay covers total free astaxanthin, the sum of its isomers. The all-trans isomer is predominant at batch control.
Carotenoid of the xanthophyll family, astaxanthin is the pigment responsible for the red color of salmon, shrimp and flamingos. Extracted from the microalga Haematococcus pluvialis, its unique molecular structure allows it to span the lipid bilayer of cell membranes from end to end, a property shared by neither beta-carotene nor vitamin E. Unlike other carotenoids, astaxanthin does not convert to vitamin A, eliminating any risk of hypervitaminosis A even at high doses. In the formula, it complements lutein and zeaxanthin (also present) to form a trio of carotenoids with complementary localizations: astaxanthin in cell membranes, lutein at the periphery of the macula, zeaxanthin at the center of the macular pigment.
0 to 6 mg
Black Garlic
Abg10+® (Garlace®) is an aqueous extract of aged black garlic bulbs (Allium sativum L.). The process combines controlled temperature and humidity, followed by water extraction. It is an ageing process involving the Maillard reaction, without microbial fermentation. The extract is standardised through an organosulfur compound profile that includes S-allyl-cysteine (SAC). It is also the material evaluated in the controlled trial conducted in adults with hypertension. The selected material uses maltodextrin as a carrier. It retains a characteristic aroma and taste, with less pungency than fresh garlic.
Black garlic earns its place in the formula through documented human cardiovascular research. Two independent controlled trials link black garlic extracts with favourable blood pressure changes: the first in adults treated for grade I hypertension, the second in adults with moderate hypercholesterolaemia. Controlled ageing of the Allium sativum bulb transforms its organosulfur profile and establishes S-allyl-cysteine as its marker. Singular sets its amount on that marker rather than on extract mass: 1.2 mg a day, the amount used in the trials.
0 to 1,200 mg
Tap to closeBlack Garlic
Abg10+® (Garlace®) is an aqueous extract of aged black garlic bulbs (Allium sativum L.). The process combines controlled temperature and humidity, followed by water extraction. It is an ageing process involving the Maillard reaction, without microbial fermentation. The extract is standardised through an organosulfur compound profile that includes S-allyl-cysteine (SAC). It is also the material evaluated in the controlled trial conducted in adults with hypertension. The selected material uses maltodextrin as a carrier. It retains a characteristic aroma and taste, with less pungency than fresh garlic.
Black garlic earns its place in the formula through documented human cardiovascular research. Two independent controlled trials link black garlic extracts with favourable blood pressure changes: the first in adults treated for grade I hypertension, the second in adults with moderate hypercholesterolaemia. Controlled ageing of the Allium sativum bulb transforms its organosulfur profile and establishes S-allyl-cysteine as its marker. Singular sets its amount on that marker rather than on extract mass: 1.2 mg a day, the amount used in the trials.
0 to 1,200 mg
Cocoa Flavanols
CocoActiv® is a cocoa bean (Theobroma cacao) extract standardised to at least 30% cocoa flavanols. Among these native polyphenols, epicatechin is the most studied. The extraction process preserves the flavanol fraction that industrial cocoa processing, particularly roasting and alkalisation, largely degrades. This specification provides consistent content from batch to batch. Powder with no excipient.
Native polyphenols of the cocoa bean (Theobroma cacao), flavanols are among the best-documented plant compounds for vascular function, led by epicatechin. Industrial cocoa processing (roasting, alkalisation) destroys most of this fraction, which is why a standardised extract is preferred over ordinary cocoa. Cocoa flavanols help maintain the elasticity of blood vessels, which contributes to normal blood flow; this effect is obtained with a daily intake of 200 mg. A cross-over trial in healthy adults compared five daily intakes: dilation of the arm artery improved from 80 mg, then continued to rise with the dose. The formula delivers 350 mg, a level chosen to also exceed the threshold of the two trials measuring, in women, skin less reactive to UV and less pronounced wrinkles. In the formula, cocoa flavanols extend the vascular axis alongside omega-3 (EPA+DHA) and black garlic, and join astaxanthin on skin resilience.
0 to 350 mg
Tap to closeCocoa Flavanols
CocoActiv® is a cocoa bean (Theobroma cacao) extract standardised to at least 30% cocoa flavanols. Among these native polyphenols, epicatechin is the most studied. The extraction process preserves the flavanol fraction that industrial cocoa processing, particularly roasting and alkalisation, largely degrades. This specification provides consistent content from batch to batch. Powder with no excipient.
Native polyphenols of the cocoa bean (Theobroma cacao), flavanols are among the best-documented plant compounds for vascular function, led by epicatechin. Industrial cocoa processing (roasting, alkalisation) destroys most of this fraction, which is why a standardised extract is preferred over ordinary cocoa. Cocoa flavanols help maintain the elasticity of blood vessels, which contributes to normal blood flow; this effect is obtained with a daily intake of 200 mg. A cross-over trial in healthy adults compared five daily intakes: dilation of the arm artery improved from 80 mg, then continued to rise with the dose. The formula delivers 350 mg, a level chosen to also exceed the threshold of the two trials measuring, in women, skin less reactive to UV and less pronounced wrinkles. In the formula, cocoa flavanols extend the vascular axis alongside omega-3 (EPA+DHA) and black garlic, and join astaxanthin on skin resilience.
0 to 350 mg
Collagen Type II
Nuvicol® II is 100% chicken sternum cartilage providing at least 3% non-denatured type II collagen, with no added excipient. The non-denatured form preserves collagen's native three-dimensional structure and specific epitopes, unlike a hydrolysed form. This natural cartilage matrix also contains chondroitin sulphate and hydroxyproline, structural components of hyaline cartilage. Type II collagen is the predominant protein in articular cartilage. Manufactured in the Netherlands.
Two collagens coexist in the formula, and they do not do the same work. Undenatured type II is here for joint comfort, on the strength of randomized trials run at 40 mg per day over three to six months. The received idea to set aside is interchangeability. Hydrolyzed collagen is cut into short peptides and serves as raw material: it is used in grams. Undenatured type II keeps its three-dimensional structure intact, and that integrity is what counts. Recognized as such by the immune system of the small intestine, it engages a process of oral tolerance. Hence doses on a wholly different scale: 40 mg of material, about 1.2 mg of the fraction that has remained native. This apparent weakness of dose is a property of the mechanism, not a formulation saving. Oral tolerance trials with collagen in humans place their optimum below the milligram, and higher doses do no better there. In the formula, undenatured type II sits alongside glucosamine, which takes the structural route by supplying the precursors of cartilage glycosaminoglycans. Vitamin C completes the set: it contributes to normal collagen formation for the normal function of cartilage.
0 to 40 mg
Tap to closeCollagen Type II
Nuvicol® II is 100% chicken sternum cartilage providing at least 3% non-denatured type II collagen, with no added excipient. The non-denatured form preserves collagen's native three-dimensional structure and specific epitopes, unlike a hydrolysed form. This natural cartilage matrix also contains chondroitin sulphate and hydroxyproline, structural components of hyaline cartilage. Type II collagen is the predominant protein in articular cartilage. Manufactured in the Netherlands.
Two collagens coexist in the formula, and they do not do the same work. Undenatured type II is here for joint comfort, on the strength of randomized trials run at 40 mg per day over three to six months. The received idea to set aside is interchangeability. Hydrolyzed collagen is cut into short peptides and serves as raw material: it is used in grams. Undenatured type II keeps its three-dimensional structure intact, and that integrity is what counts. Recognized as such by the immune system of the small intestine, it engages a process of oral tolerance. Hence doses on a wholly different scale: 40 mg of material, about 1.2 mg of the fraction that has remained native. This apparent weakness of dose is a property of the mechanism, not a formulation saving. Oral tolerance trials with collagen in humans place their optimum below the milligram, and higher doses do no better there. In the formula, undenatured type II sits alongside glucosamine, which takes the structural route by supplying the precursors of cartilage glycosaminoglycans. Vitamin C completes the set: it contributes to normal collagen formation for the normal function of cartilage.
0 to 40 mg
Collagen Types I and III
Peptan® B 2000 LD provides additive-free hydrolysed bovine collagen peptides of types I and III with an average molecular weight of 2,000 daltons and instant solubility. Hydrolysis breaks the chains into short peptides, found in human blood as di- and tripeptides after intake. The ingredient provides collagen-specific amino acids, particularly glycine, proline and hydroxyproline, which are scarce in other dietary protein sources. Manufactured in France at Rousselot's Angoulême site.
Type I and III collagen in the form of hydrolyzed peptides. Type I collagen is the most abundant structural protein in the human body, constituting approximately 90% of total collagen, found in skin, bones, tendons and ligaments. Its density in the skin declines with age, a process accelerated by UV exposure, smoking and oxidative stress. Enzymatic hydrolysis produces low-molecular-weight peptides for facilitated intestinal absorption. These peptides exert a dual action once absorbed: they supply the specific amino acids of collagen (glycine, proline, hydroxyproline) as raw material, and certain dipeptides such as Pro-Hyp steer dermal fibroblast activity in laboratory work. Meta-analyses of randomized trials have shown improvement in skin hydration and elasticity after 8 to 12 weeks of supplementation at doses of 2.5 to 10 g/day. In the formula, these peptides are part of a complete synthesis network: glycine and L-lysine (present in the formula) provide the precursor amino acids, while vitamin C (also present) is the essential cofactor for the hydroxylation of proline and lysine, the key step in collagen maturation. Without vitamin C, the collagen triple helix cannot stabilize.
0 to 5 g
Tap to closeCollagen Types I and III
Peptan® B 2000 LD provides additive-free hydrolysed bovine collagen peptides of types I and III with an average molecular weight of 2,000 daltons and instant solubility. Hydrolysis breaks the chains into short peptides, found in human blood as di- and tripeptides after intake. The ingredient provides collagen-specific amino acids, particularly glycine, proline and hydroxyproline, which are scarce in other dietary protein sources. Manufactured in France at Rousselot's Angoulême site.
Type I and III collagen in the form of hydrolyzed peptides. Type I collagen is the most abundant structural protein in the human body, constituting approximately 90% of total collagen, found in skin, bones, tendons and ligaments. Its density in the skin declines with age, a process accelerated by UV exposure, smoking and oxidative stress. Enzymatic hydrolysis produces low-molecular-weight peptides for facilitated intestinal absorption. These peptides exert a dual action once absorbed: they supply the specific amino acids of collagen (glycine, proline, hydroxyproline) as raw material, and certain dipeptides such as Pro-Hyp steer dermal fibroblast activity in laboratory work. Meta-analyses of randomized trials have shown improvement in skin hydration and elasticity after 8 to 12 weeks of supplementation at doses of 2.5 to 10 g/day. In the formula, these peptides are part of a complete synthesis network: glycine and L-lysine (present in the formula) provide the precursor amino acids, while vitamin C (also present) is the essential cofactor for the hydroxylation of proline and lysine, the key step in collagen maturation. Without vitamin C, the collagen triple helix cannot stabilize.
0 to 5 g
Copper
Copper bisglycinate: each copper atom is chelated to two glycine molecules, the smallest amino acid naturally present in the body, and itself part of the formula as a bioactive in its own right. Chelation binds the mineral to an amino acid rather than to a mineral salt such as sulphate or oxide. Copper contributes to the normal function of the immune system and to maintenance of normal connective tissues. Pure raw material. No excipient.
An essential trace element present in minute amounts in the body, yet indispensable to functions nothing else performs. Copper contributes to the protection of cells from oxidative stress: it is the catalytic cofactor of copper-zinc superoxide dismutase, one of the first lines of enzymatic defence against free radicals, where zinc (also present in the formula) occupies the structural site that holds the assembly together. It also contributes to maintenance of normal connective tissues through lysyl oxidase, the enzyme that cross-links collagen and elastin, the two proteins that give support tissues their strength and elasticity. Finally, it contributes to normal iron transport in the body via ceruloplasmin, which matters for profiles receiving iron in their formula. The body regulates its copper closely and absorbs proportionally more when dietary intake is low: the formula therefore delivers it only when a blood panel shows low status, never by default.
0 to 1 mg
Tap to closeCopper
Copper bisglycinate: each copper atom is chelated to two glycine molecules, the smallest amino acid naturally present in the body, and itself part of the formula as a bioactive in its own right. Chelation binds the mineral to an amino acid rather than to a mineral salt such as sulphate or oxide. Copper contributes to the normal function of the immune system and to maintenance of normal connective tissues. Pure raw material. No excipient.
An essential trace element present in minute amounts in the body, yet indispensable to functions nothing else performs. Copper contributes to the protection of cells from oxidative stress: it is the catalytic cofactor of copper-zinc superoxide dismutase, one of the first lines of enzymatic defence against free radicals, where zinc (also present in the formula) occupies the structural site that holds the assembly together. It also contributes to maintenance of normal connective tissues through lysyl oxidase, the enzyme that cross-links collagen and elastin, the two proteins that give support tissues their strength and elasticity. Finally, it contributes to normal iron transport in the body via ceruloplasmin, which matters for profiles receiving iron in their formula. The body regulates its copper closely and absorbs proportionally more when dietary intake is low: the formula therefore delivers it only when a blood panel shows low status, never by default.
0 to 1 mg
Creatine
Micronised creatine monohydrate (200 mesh). Micronisation reduces particle size to an ultrafine level, which favours dispersibility in solution and dissolution speed at the time of preparation. The monohydrate form is the most scientifically documented among all available creatine forms. Creatine is a molecule naturally synthesised by the body from arginine, glycine and methionine, stored primarily in skeletal muscle. Pure raw material. No excipient.
Often filed among sports performance products, creatine is first and foremost a molecule the body makes itself. Its synthesis draws on three amino acids, including glycine, also present in the formula. It fuels the phosphocreatine/ATP system, a universal energy buffer found in muscle, brain, heart and bone. It is also the most documented bioactive in human supplementation, with over a thousand published studies. Creatine increases physical performance in successive bursts of short-term, high intensity exercise. This effect concerns adults performing high intensity exercise. In adults over the age of 55 engaged in regular resistance training, daily creatine consumption can enhance the effect of that training on muscle strength. Both effects are obtained with a daily intake of 3 g of creatine, the exact dose of the formula. At 2.3 g per day for six weeks, below that dose, healthy adults gained fatigue resistance. The measurement covered five sets of repeated high-intensity efforts, with no weight gain. Muscle biopsies set the pace: at 3 g per day, with no loading phase, total muscle creatine rises by around 20 % over twenty-eight days. The reserve builds over a month, which makes regularity the decisive variable. Dietary intake comes almost exclusively from meat and fish, while the creatine selected here is obtained by chemical synthesis, with no material of animal origin. Pooled data on kidney function show no impairment: the rise in serum creatinine, a creatine degradation product, does not reflect kidney dysfunction.
0 to 3 g
Tap to closeCreatine
Micronised creatine monohydrate (200 mesh). Micronisation reduces particle size to an ultrafine level, which favours dispersibility in solution and dissolution speed at the time of preparation. The monohydrate form is the most scientifically documented among all available creatine forms. Creatine is a molecule naturally synthesised by the body from arginine, glycine and methionine, stored primarily in skeletal muscle. Pure raw material. No excipient.
Often filed among sports performance products, creatine is first and foremost a molecule the body makes itself. Its synthesis draws on three amino acids, including glycine, also present in the formula. It fuels the phosphocreatine/ATP system, a universal energy buffer found in muscle, brain, heart and bone. It is also the most documented bioactive in human supplementation, with over a thousand published studies. Creatine increases physical performance in successive bursts of short-term, high intensity exercise. This effect concerns adults performing high intensity exercise. In adults over the age of 55 engaged in regular resistance training, daily creatine consumption can enhance the effect of that training on muscle strength. Both effects are obtained with a daily intake of 3 g of creatine, the exact dose of the formula. At 2.3 g per day for six weeks, below that dose, healthy adults gained fatigue resistance. The measurement covered five sets of repeated high-intensity efforts, with no weight gain. Muscle biopsies set the pace: at 3 g per day, with no loading phase, total muscle creatine rises by around 20 % over twenty-eight days. The reserve builds over a month, which makes regularity the decisive variable. Dietary intake comes almost exclusively from meat and fish, while the creatine selected here is obtained by chemical synthesis, with no material of animal origin. Pooled data on kidney function show no impairment: the rise in serum creatinine, a creatine degradation product, does not reflect kidney dysfunction.
0 to 3 g
Curcumin
Meriva™ is a patented complex of turmeric-derived curcuminoids and sunflower-lecithin phospholipids, standardised to 18-22% total curcuminoids. These polyphenols give the turmeric rhizome (Curcuma longa) its characteristic orange colour. Extraction with food-grade ethyl acetate yields a native extract at a 30:1 ratio. The resulting complex is carried on microcrystalline cellulose (E460(i)). Turmeric has been used in Ayurvedic tradition for millennia. As curcumin is naturally fat-soluble and poorly absorbed on its own, the phospholipid carrier is an integral part of the ingredient. Preservative-free.
The principal polyphenol of the turmeric rhizome (Curcuma longa), the golden spice at the heart of the Ayurvedic tradition for over 4,000 years. Curcumin is one of the most studied plant compounds in the world, with more than 28,000 publications indexed on PubMed. Its naturally limited oral bioavailability has been the primary galenic challenge: in its native form, curcumin is rapidly metabolized by the liver. A double-blind human crossover trial, run in the same volunteers and adjusted for dose, places absorption of the curcuminoid-phospholipid complex at 7.9 times that of the unformulated curcuminoid mixture. Sixteen controlled trials bringing together 1,810 adults measure a drop in knee pain and a gain in function; sixty-six trials measure a drop in C-reactive protein and a rise in the blood's antioxidant defences. In the formula, curcumin is paired with ginger (Zingiber officinale, also present), another member of the Zingiberaceae botanical family. These two rhizomes, used together for millennia in traditional medicine, present complementary activity spectra.
0 to 125 mg
Tap to closeCurcumin
Meriva™ is a patented complex of turmeric-derived curcuminoids and sunflower-lecithin phospholipids, standardised to 18-22% total curcuminoids. These polyphenols give the turmeric rhizome (Curcuma longa) its characteristic orange colour. Extraction with food-grade ethyl acetate yields a native extract at a 30:1 ratio. The resulting complex is carried on microcrystalline cellulose (E460(i)). Turmeric has been used in Ayurvedic tradition for millennia. As curcumin is naturally fat-soluble and poorly absorbed on its own, the phospholipid carrier is an integral part of the ingredient. Preservative-free.
The principal polyphenol of the turmeric rhizome (Curcuma longa), the golden spice at the heart of the Ayurvedic tradition for over 4,000 years. Curcumin is one of the most studied plant compounds in the world, with more than 28,000 publications indexed on PubMed. Its naturally limited oral bioavailability has been the primary galenic challenge: in its native form, curcumin is rapidly metabolized by the liver. A double-blind human crossover trial, run in the same volunteers and adjusted for dose, places absorption of the curcuminoid-phospholipid complex at 7.9 times that of the unformulated curcuminoid mixture. Sixteen controlled trials bringing together 1,810 adults measure a drop in knee pain and a gain in function; sixty-six trials measure a drop in C-reactive protein and a rise in the blood's antioxidant defences. In the formula, curcumin is paired with ginger (Zingiber officinale, also present), another member of the Zingiberaceae botanical family. These two rhizomes, used together for millennia in traditional medicine, present complementary activity spectra.
0 to 125 mg
Galacto-oligosaccharides (GOS)
Vivinal® GOS is a concentrated soluble galacto-oligosaccharide fibre produced using proprietary enzymatic technology. These non-digestible prebiotics serve as a selective substrate for beneficial gut bacteria, particularly bifidobacteria. The ingredient contains a spectrum of oligosaccharide chains from DP2 to DP8, or 2 to 8 galactose units. Its taste is slightly sweet. Derived from milk lactose, this powder consists of 97% milk solids: 69% GOS, 23% lactose and other disaccharides, and 5% glucose and galactose.
Non-digestible prebiotic fibers produced by enzymatic transgalactosylation of lactose. GOS (galacto-oligosaccharides) are structurally similar to human milk oligosaccharides (HMOs), the natural fibers that shape the infant microbiota from the very first hours of life. Not digested in the small intestine, GOS reach the colon intact where they are selectively fermented by bifidobacteria and lactobacilli, the bacterial genera that are pillars of a balanced microbiota. This fermentation produces short-chain fatty acids (butyrate, propionate, acetate), energy sources for colonocytes and modulators of intestinal pH. Butyrate nourishes the cells of the colonic mucosa. GOS differ from FOS (fructo-oligosaccharides) in their galactosidic structure, which gives them superior digestive tolerance with less bloating. In the formula, GOS act upstream of the microbiota by feeding each person's resident bifidobacteria, without relying on colonization delivered by the supplement. Acacia fiber completes this system through slower, more gradual fermentation. This network approach aims to support microbiota diversity, whose decline is a marker of biological aging.
0 to 5 g
Tap to closeGalacto-oligosaccharides (GOS)
Vivinal® GOS is a concentrated soluble galacto-oligosaccharide fibre produced using proprietary enzymatic technology. These non-digestible prebiotics serve as a selective substrate for beneficial gut bacteria, particularly bifidobacteria. The ingredient contains a spectrum of oligosaccharide chains from DP2 to DP8, or 2 to 8 galactose units. Its taste is slightly sweet. Derived from milk lactose, this powder consists of 97% milk solids: 69% GOS, 23% lactose and other disaccharides, and 5% glucose and galactose.
Non-digestible prebiotic fibers produced by enzymatic transgalactosylation of lactose. GOS (galacto-oligosaccharides) are structurally similar to human milk oligosaccharides (HMOs), the natural fibers that shape the infant microbiota from the very first hours of life. Not digested in the small intestine, GOS reach the colon intact where they are selectively fermented by bifidobacteria and lactobacilli, the bacterial genera that are pillars of a balanced microbiota. This fermentation produces short-chain fatty acids (butyrate, propionate, acetate), energy sources for colonocytes and modulators of intestinal pH. Butyrate nourishes the cells of the colonic mucosa. GOS differ from FOS (fructo-oligosaccharides) in their galactosidic structure, which gives them superior digestive tolerance with less bloating. In the formula, GOS act upstream of the microbiota by feeding each person's resident bifidobacteria, without relying on colonization delivered by the supplement. Acacia fiber completes this system through slower, more gradual fermentation. This network approach aims to support microbiota diversity, whose decline is a marker of biological aging.
0 to 5 g
Ginger
Ginger rhizome extract (Zingiber officinale), standardised in gingerols, the primary bioactive compounds of the plant. Extraction is performed from the whole rhizome by a hydro-alcoholic process, using ethanol and water. A 15:1 ratio concentrates fifteen parts of dried rhizome into one part of extract. The extract is standardised to at least 10% gingerols by HPLC, twice the assay of standard 5% extracts. Ginger has been used for millennia in Ayurvedic and Chinese traditions.
Rhizome of Zingiber officinale, a tropical plant cultivated and used in Asian culinary and herbal traditions for millennia. Ginger owes its properties to its richness in gingerols and shogaols, pungent phenolic compounds. 6-gingerol dominates in the fresh rhizome, 6-shogaol in dried and concentrated forms, where thermal dehydration converts the first into the second. Its place in the formula rests first on the digestive sphere, where its action is local and best established: a double-blind crossover trial measures accelerated stomach emptying in healthy volunteers. Meta-analyses covering dozens of controlled trials further record a fall in C-reactive protein, a drop in fasting glucose in adults whose level is elevated, and a rise in HDL cholesterol. Ginger pairs with curcumin, another Zingiberaceae present in the formula. The two rhizomes, combined for centuries in Asian cooking, cover complementary ground.
0 to 150 mg
Tap to closeGinger
Ginger rhizome extract (Zingiber officinale), standardised in gingerols, the primary bioactive compounds of the plant. Extraction is performed from the whole rhizome by a hydro-alcoholic process, using ethanol and water. A 15:1 ratio concentrates fifteen parts of dried rhizome into one part of extract. The extract is standardised to at least 10% gingerols by HPLC, twice the assay of standard 5% extracts. Ginger has been used for millennia in Ayurvedic and Chinese traditions.
Rhizome of Zingiber officinale, a tropical plant cultivated and used in Asian culinary and herbal traditions for millennia. Ginger owes its properties to its richness in gingerols and shogaols, pungent phenolic compounds. 6-gingerol dominates in the fresh rhizome, 6-shogaol in dried and concentrated forms, where thermal dehydration converts the first into the second. Its place in the formula rests first on the digestive sphere, where its action is local and best established: a double-blind crossover trial measures accelerated stomach emptying in healthy volunteers. Meta-analyses covering dozens of controlled trials further record a fall in C-reactive protein, a drop in fasting glucose in adults whose level is elevated, and a rise in HDL cholesterol. Ginger pairs with curcumin, another Zingiberaceae present in the formula. The two rhizomes, combined for centuries in Asian cooking, cover complementary ground.
0 to 150 mg
Glucosamine
Amino sugar naturally present in cartilage. The selected product is derived from the chitin of crustacean shells: it is not suitable for vegetarian or vegan diets. Quality: no excipient.
Amino sugar naturally present in human cartilage, where it is a key constituent of glycosaminoglycans and proteoglycans, the molecules that give cartilage its cushioning and mechanical resistance properties. Glucosamine is the direct precursor of hyaluronic acid and keratan sulfates, essential components of the extracellular matrix of articular cartilage. Its endogenous production by chondrocytes (cartilage cells) decreases with age, contributing to the progressive thinning of cartilage observed during aging. The sulfate form is preferred because the sulfate group is itself necessary for the synthesis of sulfated glycosaminoglycans. Numerous clinical studies have evaluated glucosamine sulfate at doses of 1,500 mg/day, making it one of the most documented joint supplements in the world. Randomized trials spanning 3 years have shown a slowing of articular cartilage thickness loss measured by radiography. In the formula, glucosamine works in complementarity with undenatured type II collagen (also present). These two actives take distinct pathways: glucosamine provides the building blocks for glycosaminoglycans, while type II collagen modulates the immune response toward cartilage through oral tolerance. Two complementary mechanisms to support joint comfort.
0 to 1,118 mg
Tap to closeGlucosamine
Amino sugar naturally present in cartilage. The selected product is derived from the chitin of crustacean shells: it is not suitable for vegetarian or vegan diets. Quality: no excipient.
Amino sugar naturally present in human cartilage, where it is a key constituent of glycosaminoglycans and proteoglycans, the molecules that give cartilage its cushioning and mechanical resistance properties. Glucosamine is the direct precursor of hyaluronic acid and keratan sulfates, essential components of the extracellular matrix of articular cartilage. Its endogenous production by chondrocytes (cartilage cells) decreases with age, contributing to the progressive thinning of cartilage observed during aging. The sulfate form is preferred because the sulfate group is itself necessary for the synthesis of sulfated glycosaminoglycans. Numerous clinical studies have evaluated glucosamine sulfate at doses of 1,500 mg/day, making it one of the most documented joint supplements in the world. Randomized trials spanning 3 years have shown a slowing of articular cartilage thickness loss measured by radiography. In the formula, glucosamine works in complementarity with undenatured type II collagen (also present). These two actives take distinct pathways: glucosamine provides the building blocks for glycosaminoglycans, while type II collagen modulates the immune response toward cartilage through oral tolerance. Two complementary mechanisms to support joint comfort.
0 to 1,118 mg
Glycine
Glycine is the smallest and simplest of the amino acids. It accounts for roughly one third of the amino acids in collagen and provides one of the three building blocks of glutathione, the antioxidant that cells manufacture themselves. Depending on your profile, it may be present in your formula in two forms, both counted in the displayed dose. Added as a dedicated bioactive, it comes as free-form L-glycine: the amino acid on its own, not bound to another compound. The material selected is European Pharmacopoeia grade, with an assay between 98.5 and 101.5%. Delivered through magnesium, it comes as magnesium bisglycinate, a salt in which two glycine molecules are bound to a magnesium atom.
The simplest and smallest amino acid, and far from the least important: glycine accounts for roughly one third of the amino acids in collagen, the most abundant protein in the human body. It is described as conditionally essential, meaning the body produces it without always keeping pace with what it consumes. Glycine sits at a metabolic crossroads within the formula. It is a direct precursor of glutathione, alongside N-Acetylcysteine which supplies the cysteine. It is also one of the three precursors of creatine, itself present. And it provides one of the structural amino acids of type I, III and II collagens, all present. Beyond these intersections, glycine takes part in the hepatic conjugation of bile acids and acts as an inhibitory neurotransmitter in the central nervous system. Its own human evidence lies elsewhere: in crossover trials at 3 g taken before bedtime, in adults who reported poor sleep quality.
0 to 3 g
Tap to closeGlycine
Glycine is the smallest and simplest of the amino acids. It accounts for roughly one third of the amino acids in collagen and provides one of the three building blocks of glutathione, the antioxidant that cells manufacture themselves. Depending on your profile, it may be present in your formula in two forms, both counted in the displayed dose. Added as a dedicated bioactive, it comes as free-form L-glycine: the amino acid on its own, not bound to another compound. The material selected is European Pharmacopoeia grade, with an assay between 98.5 and 101.5%. Delivered through magnesium, it comes as magnesium bisglycinate, a salt in which two glycine molecules are bound to a magnesium atom.
The simplest and smallest amino acid, and far from the least important: glycine accounts for roughly one third of the amino acids in collagen, the most abundant protein in the human body. It is described as conditionally essential, meaning the body produces it without always keeping pace with what it consumes. Glycine sits at a metabolic crossroads within the formula. It is a direct precursor of glutathione, alongside N-Acetylcysteine which supplies the cysteine. It is also one of the three precursors of creatine, itself present. And it provides one of the structural amino acids of type I, III and II collagens, all present. Beyond these intersections, glycine takes part in the hepatic conjugation of bile acids and acts as an inhibitory neurotransmitter in the central nervous system. Its own human evidence lies elsewhere: in crossover trials at 3 g taken before bedtime, in adults who reported poor sleep quality.
0 to 3 g
Hyaluronic Acid
ExceptionHYAL® Star is a patented sodium hyaluronate from Roelmi HPC, produced by bacterial fermentation without animal-derived raw materials. It combines several molecular weights.
Hyaluronic acid is naturally present in the skin’s extracellular matrix, where it contributes to water retention and the mechanical properties of tissues. Two controlled human trials evaluated ExceptionHYAL® Star at 200 mg per day for 28 or 56 days. They report instrumental improvements in hydration and several skin parameters. This direct human evidence places hydration at the heart of its selection for the Singular formula.
0 to 200 mg
Tap to closeHyaluronic Acid
ExceptionHYAL® Star is a patented sodium hyaluronate from Roelmi HPC, produced by bacterial fermentation without animal-derived raw materials. It combines several molecular weights.
Hyaluronic acid is naturally present in the skin’s extracellular matrix, where it contributes to water retention and the mechanical properties of tissues. Two controlled human trials evaluated ExceptionHYAL® Star at 200 mg per day for 28 or 56 days. They report instrumental improvements in hydration and several skin parameters. This direct human evidence places hydration at the heart of its selection for the Singular formula.
0 to 200 mg
Iodine
Potassium iodide (KI) spray-dried onto a maltodextrin carrier, which accounts for most of its mass. Potassium iodide provides a fixed, known ratio between the salt and the iodine it contains, where seaweed extracts vary from batch to batch. This dilution carrier allows a microgram-scale dose to be distributed evenly throughout the formula. Iodine contributes to the normal production of thyroid hormones and normal thyroid function, and to normal cognitive function.
Iodine contributes to the normal production of thyroid hormones and normal thyroid function, to normal cognitive function and to normal energy-yielding metabolism. An essential constituent of the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine), iodine holds a central position in regulating the basal metabolism of virtually every cell in the body. The thyroid concentrates circulating iodine to synthesize T4, which is then converted to T3 (the active form) by enzymes called deiodinases, whose activity depends on selenium (also present in the formula). This iodine-selenium synergy governs the conversion of T4 into T3. Despite table salt iodization in many countries, nutritional surveys reveal that certain populations remain at suboptimal intake, particularly people limiting their consumption of salt, dairy or fish. Thyroid function directly influences thermogenesis, heart rate, cell renewal and cognitive functions. Its useful window is narrow in both directions, with insufficient intake and excessive intake alike disturbing the gland, which makes reading iodine status relevant from a longevity perspective. Potassium iodide form, stable and well absorbed.
0 to 150 µg
Tap to closeIodine
Potassium iodide (KI) spray-dried onto a maltodextrin carrier, which accounts for most of its mass. Potassium iodide provides a fixed, known ratio between the salt and the iodine it contains, where seaweed extracts vary from batch to batch. This dilution carrier allows a microgram-scale dose to be distributed evenly throughout the formula. Iodine contributes to the normal production of thyroid hormones and normal thyroid function, and to normal cognitive function.
Iodine contributes to the normal production of thyroid hormones and normal thyroid function, to normal cognitive function and to normal energy-yielding metabolism. An essential constituent of the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine), iodine holds a central position in regulating the basal metabolism of virtually every cell in the body. The thyroid concentrates circulating iodine to synthesize T4, which is then converted to T3 (the active form) by enzymes called deiodinases, whose activity depends on selenium (also present in the formula). This iodine-selenium synergy governs the conversion of T4 into T3. Despite table salt iodization in many countries, nutritional surveys reveal that certain populations remain at suboptimal intake, particularly people limiting their consumption of salt, dairy or fish. Thyroid function directly influences thermogenesis, heart rate, cell renewal and cognitive functions. Its useful window is narrow in both directions, with insufficient intake and excessive intake alike disturbing the gland, which makes reading iodine status relevant from a longevity perspective. Potassium iodide form, stable and well absorbed.
0 to 150 µg
Iron
PHARMAGNESIA® FBg A is a fully reacted ferrous bisglycinate hydrochloride containing 17 to 22% elemental iron and no added excipient. Each iron atom (Fe2+) is bonded to two glycine molecules, which form the chelate's intrinsic ligand. Iron contributes to the reduction of tiredness and fatigue, and to normal oxygen transport in the body.
Iron contributes to normal formation of red blood cells and haemoglobin, to normal oxygen transport in the body and to the reduction of tiredness and fatigue. Included only according to your profile. Iron is a double-edged element: indispensable for oxygen transport and cellular respiration, but potentially pro-oxidant in excess via the Fenton reaction. This is why its supplementation is personalized and not systematic in the formula. Vitamin C (present in the formula) increases non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract. The balance with zinc and copper (also present in the formula in bisglycinate form) is carefully calibrated to avoid mineral absorption competition. Two randomised trials in pregnant women, over three to five months, compared iron bisglycinate with ferrous sulphate: at 15 then 25 mg of iron against 40 and 50 mg, it maintained iron status with fewer digestive complaints. The dose is calibrated on ferritin, transferrin saturation and haemoglobin, three markers re-read at every blood panel.
0 to 21 mg
Tap to closeIron
PHARMAGNESIA® FBg A is a fully reacted ferrous bisglycinate hydrochloride containing 17 to 22% elemental iron and no added excipient. Each iron atom (Fe2+) is bonded to two glycine molecules, which form the chelate's intrinsic ligand. Iron contributes to the reduction of tiredness and fatigue, and to normal oxygen transport in the body.
Iron contributes to normal formation of red blood cells and haemoglobin, to normal oxygen transport in the body and to the reduction of tiredness and fatigue. Included only according to your profile. Iron is a double-edged element: indispensable for oxygen transport and cellular respiration, but potentially pro-oxidant in excess via the Fenton reaction. This is why its supplementation is personalized and not systematic in the formula. Vitamin C (present in the formula) increases non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract. The balance with zinc and copper (also present in the formula in bisglycinate form) is carefully calibrated to avoid mineral absorption competition. Two randomised trials in pregnant women, over three to five months, compared iron bisglycinate with ferrous sulphate: at 15 then 25 mg of iron against 40 and 50 mg, it maintained iron status with fewer digestive complaints. The dose is calibrated on ferritin, transferrin saturation and haemoglobin, three markers re-read at every blood panel.
0 to 21 mg
L-Theanine
Aqueous extract of green tea leaves (Camellia sinensis L.), standardised to a minimum of 40% L-theanine (HPLC). L-theanine is a non-proteinogenic amino acid, meaning it does not form part of the body's proteins. In nature, it is found almost exclusively in tea leaves. Extraction uses water alone, with no hexane, and concentrates 25 kg of leaves into 1 kg of extract. The theanine obtained is therefore the plant's own: no synthetic theanine is added. The remaining 60% is the natural green tea matrix, around 18% catechins (including 3 to 6% EGCG) and 0.3% caffeine. The leaves are harvested in China.
Non-proteinogenic amino acid found almost exclusively in tea leaves (Camellia sinensis), where it represents up to 50% of free amino acids. It is L-theanine that gives green tea its distinctive umami character. Structurally analogous to glutamate, it has been studied since the 1960s in Japan. L-theanine crosses the blood-brain barrier and reaches the brain approximately 30 minutes after oral ingestion. Electroencephalographic studies show that it promotes the production of alpha waves (8-13 Hz), a brain state associated with wakeful relaxation and calm focus. This state of serene alertness, between drowsiness and mental hyperactivity, is precisely what individuals facing sustained cognitive demands seek. Several controlled trials have also explored its influence on sleep quality, with results suggesting improvement in sleep onset and subjective perception of rest. Its safety profile is firmly documented by decades of consumption through tea, and supplementation studies report no significant side effects at usual doses.
0 to 200 mg
Tap to closeL-Theanine
Aqueous extract of green tea leaves (Camellia sinensis L.), standardised to a minimum of 40% L-theanine (HPLC). L-theanine is a non-proteinogenic amino acid, meaning it does not form part of the body's proteins. In nature, it is found almost exclusively in tea leaves. Extraction uses water alone, with no hexane, and concentrates 25 kg of leaves into 1 kg of extract. The theanine obtained is therefore the plant's own: no synthetic theanine is added. The remaining 60% is the natural green tea matrix, around 18% catechins (including 3 to 6% EGCG) and 0.3% caffeine. The leaves are harvested in China.
Non-proteinogenic amino acid found almost exclusively in tea leaves (Camellia sinensis), where it represents up to 50% of free amino acids. It is L-theanine that gives green tea its distinctive umami character. Structurally analogous to glutamate, it has been studied since the 1960s in Japan. L-theanine crosses the blood-brain barrier and reaches the brain approximately 30 minutes after oral ingestion. Electroencephalographic studies show that it promotes the production of alpha waves (8-13 Hz), a brain state associated with wakeful relaxation and calm focus. This state of serene alertness, between drowsiness and mental hyperactivity, is precisely what individuals facing sustained cognitive demands seek. Several controlled trials have also explored its influence on sleep quality, with results suggesting improvement in sleep onset and subjective perception of rest. Its safety profile is firmly documented by decades of consumption through tea, and supplementation studies report no significant side effects at usual doses.
0 to 200 mg
Lutein
XanMax® 2505 is a Tagetes erecta flower extract produced at a 400:1 extraction ratio and standardised to at least 25% lutein and 5% zeaxanthin. Lutein is a carotenoid of the xanthophyll family that naturally concentrates in the macula, the central area of the retina responsible for fine vision. The human body cannot synthesise it, so it must be obtained through the diet.
Carotenoid of the xanthophyll family, extracted from marigold petals (Tagetes erecta). Lutein concentrates in the macula of the retina, at the periphery of the fovea, where it forms the macular pigment together with zeaxanthin. The two travel together: the same raw material supplies them in the 5:1 ratio of our diet, which is also the one administered in the reference trials. The structure of the molecule absorbs light between 400 and 500 nm, an optical property measured in the laboratory that gives it its yellow colour. The density of this pigment is measured in humans without any sampling, and it rises with intake: this is the quantity on which most trials rest, and it increases with dose. The body does not synthesise lutein. Dietary intakes recorded in European adults remain well below the doses used in trials.
0 to 20 mg
Tap to closeLutein
XanMax® 2505 is a Tagetes erecta flower extract produced at a 400:1 extraction ratio and standardised to at least 25% lutein and 5% zeaxanthin. Lutein is a carotenoid of the xanthophyll family that naturally concentrates in the macula, the central area of the retina responsible for fine vision. The human body cannot synthesise it, so it must be obtained through the diet.
Carotenoid of the xanthophyll family, extracted from marigold petals (Tagetes erecta). Lutein concentrates in the macula of the retina, at the periphery of the fovea, where it forms the macular pigment together with zeaxanthin. The two travel together: the same raw material supplies them in the 5:1 ratio of our diet, which is also the one administered in the reference trials. The structure of the molecule absorbs light between 400 and 500 nm, an optical property measured in the laboratory that gives it its yellow colour. The density of this pigment is measured in humans without any sampling, and it rises with intake: this is the quantity on which most trials rest, and it increases with dose. The body does not synthesise lutein. Dietary intakes recorded in European adults remain well below the doses used in trials.
0 to 20 mg
Magnesium
Anhydrous magnesium bisglycinate, fully reacted: each magnesium atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Unlike partially chelated bisglycinate on the market, this form contains no residual oxide or inorganic magnesium. The anhydrous form concentrates more elemental magnesium per gram. Result: a well-absorbed organic form, and a digestive tolerance that sets it apart from the laxative salts. Magnesium contributes to a reduction of tiredness and fatigue. Magnesium contributes to normal functioning of the nervous system. No excipient.
Magnesium contributes to a reduction of tiredness and fatigue, to normal functioning of the nervous system, to normal muscle function, to normal energy-yielding metabolism, to normal psychological function, to normal protein synthesis, to the maintenance of normal bones and normal teeth, to electrolyte balance, and it has a role in the process of cell division. Cofactor of over 600 enzymatic reactions, magnesium is the most broadly involved mineral in human cellular metabolism. It forms the Mg-ATP complex, the active form of cellular energy, and is involved in DNA replication, protein synthesis, nerve transmission and muscle contraction. DNA repair systems also depend on its presence. Epidemiological studies estimate that approximately 50 to 75% of the Western population does not reach the recommended daily intake. In the formula, magnesium participates in the bone axis alongside vitamin D3, and vitamin K2-MK7. Bisglycinate form, chelated to two glycines, selected for its digestive tolerance: it lacks the osmotic laxative effect that limits the tolerable doses of inorganic salts.
0 to 360 mg
Tap to closeMagnesium
Anhydrous magnesium bisglycinate, fully reacted: each magnesium atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Unlike partially chelated bisglycinate on the market, this form contains no residual oxide or inorganic magnesium. The anhydrous form concentrates more elemental magnesium per gram. Result: a well-absorbed organic form, and a digestive tolerance that sets it apart from the laxative salts. Magnesium contributes to a reduction of tiredness and fatigue. Magnesium contributes to normal functioning of the nervous system. No excipient.
Magnesium contributes to a reduction of tiredness and fatigue, to normal functioning of the nervous system, to normal muscle function, to normal energy-yielding metabolism, to normal psychological function, to normal protein synthesis, to the maintenance of normal bones and normal teeth, to electrolyte balance, and it has a role in the process of cell division. Cofactor of over 600 enzymatic reactions, magnesium is the most broadly involved mineral in human cellular metabolism. It forms the Mg-ATP complex, the active form of cellular energy, and is involved in DNA replication, protein synthesis, nerve transmission and muscle contraction. DNA repair systems also depend on its presence. Epidemiological studies estimate that approximately 50 to 75% of the Western population does not reach the recommended daily intake. In the formula, magnesium participates in the bone axis alongside vitamin D3, and vitamin K2-MK7. Bisglycinate form, chelated to two glycines, selected for its digestive tolerance: it lacks the osmotic laxative effect that limits the tolerable doses of inorganic salts.
0 to 360 mg
N-Acetylcysteine
N-acetyl-L-cysteine of Ph. Eur. and USP grade, obtained by synthesis-fermentation from L-cysteine of non-animal origin. The acetyl group stabilises the molecule: free L-cysteine oxidises spontaneously, whereas the acetylated form stays intact in solution. Once absorbed, it releases cysteine, the sulphur amino acid that laboratory work describes as rate-limiting in glutathione synthesis. White crystalline powder, freely soluble in water.
Stabilised form of cysteine, selected because both direct routes fail: free L-cysteine oxidises spontaneously in the digestive tract, and glutathione taken as such is cleaved by intestinal peptidases before reaching the circulation. In laboratory work, cysteine is the rate-limiting link in glutathione synthesis; glycine, also present in the formula, supplies a second substrate. In adults, a meta-analysis of twenty-four randomised trials of oral supplementation measures a drop in C-reactive protein and interleukin-6, at doses of 400 to 2,000 mg per day. NAC is not a default component: the engine adds it only for certain profiles, at 600 mg per day, the maximum daily amount authorised in France for this substance.
0 to 600 mg
Tap to closeN-Acetylcysteine
N-acetyl-L-cysteine of Ph. Eur. and USP grade, obtained by synthesis-fermentation from L-cysteine of non-animal origin. The acetyl group stabilises the molecule: free L-cysteine oxidises spontaneously, whereas the acetylated form stays intact in solution. Once absorbed, it releases cysteine, the sulphur amino acid that laboratory work describes as rate-limiting in glutathione synthesis. White crystalline powder, freely soluble in water.
Stabilised form of cysteine, selected because both direct routes fail: free L-cysteine oxidises spontaneously in the digestive tract, and glutathione taken as such is cleaved by intestinal peptidases before reaching the circulation. In laboratory work, cysteine is the rate-limiting link in glutathione synthesis; glycine, also present in the formula, supplies a second substrate. In adults, a meta-analysis of twenty-four randomised trials of oral supplementation measures a drop in C-reactive protein and interleukin-6, at doses of 400 to 2,000 mg per day. NAC is not a default component: the engine adds it only for certain profiles, at 600 mg per day, the maximum daily amount authorised in France for this substance.
0 to 600 mg
Omega-3 (EPA+DHA)
AvailOm® 50 High EPA is a lysine salt of omega-3 fatty acids, derived from purified fish oil and manufactured in France by Evonik Rexim. The free fatty acids are bonded to L-lysine obtained through fermentation. This ionic structure makes them water-soluble: their absorption no longer depends on bile secretion, which classic oils require. It also gives them an oxidation resistance that holds for several years without any additive, where liquid oils turn rancid. Dioxins, PCBs, heavy metals and aromatic hydrocarbons are controlled against European regulatory limits.
EPA and DHA are among the few nutritional levers whose effect reads on a marker already present in the blood panel: triglycerides. That marker alone commands a reinforced dose, and only when it runs very high. EPA and DHA contribute to the normal function of the heart (effect obtained with 250 mg/day), and DHA to maintenance of normal brain function as well as to the maintenance of normal vision (effect obtained with 250 mg/day of DHA). When measured triglycerides run very high, the delivered dose rises to the tier that carries a fourth contribution: the maintenance of normal blood triglyceride levels (effect obtained with 2 g/day). DHA represents approximately 40% of polyunsaturated fatty acids in the brain and 60% in the retina, explaining its structural role in these high metabolic activity tissues. EPA acts through an entirely distinct pathway. Delivering both covers the two, where favouring one means giving up the other.
0 to 2 g
Tap to closeOmega-3 (EPA+DHA)
AvailOm® 50 High EPA is a lysine salt of omega-3 fatty acids, derived from purified fish oil and manufactured in France by Evonik Rexim. The free fatty acids are bonded to L-lysine obtained through fermentation. This ionic structure makes them water-soluble: their absorption no longer depends on bile secretion, which classic oils require. It also gives them an oxidation resistance that holds for several years without any additive, where liquid oils turn rancid. Dioxins, PCBs, heavy metals and aromatic hydrocarbons are controlled against European regulatory limits.
EPA and DHA are among the few nutritional levers whose effect reads on a marker already present in the blood panel: triglycerides. That marker alone commands a reinforced dose, and only when it runs very high. EPA and DHA contribute to the normal function of the heart (effect obtained with 250 mg/day), and DHA to maintenance of normal brain function as well as to the maintenance of normal vision (effect obtained with 250 mg/day of DHA). When measured triglycerides run very high, the delivered dose rises to the tier that carries a fourth contribution: the maintenance of normal blood triglyceride levels (effect obtained with 2 g/day). DHA represents approximately 40% of polyunsaturated fatty acids in the brain and 60% in the retina, explaining its structural role in these high metabolic activity tissues. EPA acts through an entirely distinct pathway. Delivering both covers the two, where favouring one means giving up the other.
0 to 2 g
PQQ
MGCPQQ® is a pyrroloquinoline quinone disodium dihydrate of more than 99% purity, produced by fermenting a strain of Hyphomicrobium denitrificans. PQQ is a redox cofactor with a tricyclic aromatic structure, naturally present in trace amounts in foods such as kiwi, parsley, green tea and breast milk. This form provides the stability and solubility sought for oral use and is the form used in the majority of published clinical trials. Manufactured by Mitsubishi Gas Chemical.
A redox cofactor first isolated from a bacterium in 1979, and naturally present in kiwi, parsley, green tea and breast milk, at levels in the nanogram-per-gram range. Its candidacy for vitamin status, put forward in the early 2000s, was not upheld: PQQ remains a redox cofactor, not an essential nutrient. What sets it apart is its stability. In chemistry, it runs through thousands of redox cycles without degrading, where ascorbic acid manages a handful. Four placebo-controlled trials have evaluated it on a cognitive endpoint, three at the exact dose we deliver. The number and quality of mitochondria decline with age, a process that contributes directly to the loss of cellular energy. That is the axis on which PQQ is retained.
0 to 20 mg
Tap to closePQQ
MGCPQQ® is a pyrroloquinoline quinone disodium dihydrate of more than 99% purity, produced by fermenting a strain of Hyphomicrobium denitrificans. PQQ is a redox cofactor with a tricyclic aromatic structure, naturally present in trace amounts in foods such as kiwi, parsley, green tea and breast milk. This form provides the stability and solubility sought for oral use and is the form used in the majority of published clinical trials. Manufactured by Mitsubishi Gas Chemical.
A redox cofactor first isolated from a bacterium in 1979, and naturally present in kiwi, parsley, green tea and breast milk, at levels in the nanogram-per-gram range. Its candidacy for vitamin status, put forward in the early 2000s, was not upheld: PQQ remains a redox cofactor, not an essential nutrient. What sets it apart is its stability. In chemistry, it runs through thousands of redox cycles without degrading, where ascorbic acid manages a handful. Four placebo-controlled trials have evaluated it on a cognitive endpoint, three at the exact dose we deliver. The number and quality of mitochondria decline with age, a process that contributes directly to the loss of cellular energy. That is the axis on which PQQ is retained.
0 to 20 mg
Selenium
L-selenomethionine, an organic form of selenium where the selenium atom replaces sulphur in methionine, an essential amino acid. This form exactly replicates the selenium naturally present in food (cereals, Brazil nuts, legumes). Unlike inorganic forms (selenite, selenate), selenomethionine is recognised by intestinal amino acid transporters, providing significantly higher oral bioavailability. Selenium contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Selenium contributes to the protection of cells from oxidative stress, to the normal function of the immune system, to normal thyroid function and to the maintenance of normal hair and normal nails. The human genome encodes 25 selenoproteins, including glutathione peroxidases (enzymes that neutralize hydrogen peroxide and lipid hydroperoxides) and thioredoxin reductases, involved in regenerating intracellular antioxidant systems. In selenomethionine form, selenium is non-specifically incorporated into body proteins in place of methionine, creating a reservoir mobilizable according to the body's needs. Selenium content in European soils is generally lower than in North American soils, resulting in variable dietary intakes across regions. The deiodinases, enzymes responsible for converting thyroxine (T4) to triiodothyronine (T3, the active form), are themselves selenoproteins. Selenium and iodine (also present in the formula) therefore work in tandem to support normal thyroid function.
0 to 100 µg
Tap to closeSelenium
L-selenomethionine, an organic form of selenium where the selenium atom replaces sulphur in methionine, an essential amino acid. This form exactly replicates the selenium naturally present in food (cereals, Brazil nuts, legumes). Unlike inorganic forms (selenite, selenate), selenomethionine is recognised by intestinal amino acid transporters, providing significantly higher oral bioavailability. Selenium contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Selenium contributes to the protection of cells from oxidative stress, to the normal function of the immune system, to normal thyroid function and to the maintenance of normal hair and normal nails. The human genome encodes 25 selenoproteins, including glutathione peroxidases (enzymes that neutralize hydrogen peroxide and lipid hydroperoxides) and thioredoxin reductases, involved in regenerating intracellular antioxidant systems. In selenomethionine form, selenium is non-specifically incorporated into body proteins in place of methionine, creating a reservoir mobilizable according to the body's needs. Selenium content in European soils is generally lower than in North American soils, resulting in variable dietary intakes across regions. The deiodinases, enzymes responsible for converting thyroxine (T4) to triiodothyronine (T3, the active form), are themselves selenoproteins. Selenium and iodine (also present in the formula) therefore work in tandem to support normal thyroid function.
0 to 100 µg
Sulforaphane
Sulfodyne® is a broccoli seed extract (Brassica oleracea var. italica) patented by Ingood by Olga, standardized for free, stabilized sulforaphane. Most broccoli extracts supply glucoraphanin, an inactive precursor that gut flora must hydrolyse to release sulforaphane, a conversion that depends on the microbiome and on gastric acidity. A patented stabilization process delivers the isothiocyanate directly in its active form, with no intermediate enzymatic step. European seed origin, manufactured in France.
Sulphur-containing isothiocyanate from cruciferous vegetables, concentrated in broccoli seeds and young sprouts, where the content of glucoraphanin — its precursor — is ten to one hundred times that of mature broccoli. Sulforaphane is formed by the action of the enzyme myrosinase on glucoraphanin during chewing or processing; the selected extract already supplies it in its free form, without that step. With over three thousand publications, it is one of the most studied plant compounds of the decade. In the laboratory, it triggers a cellular defence programme: a brief molecular stress that sets off the reading of several hundred protective genes, including those of the enzymes that neutralise and clear unwanted compounds. In humans, what is measured lies downstream: in 291 adults exposed to air pollution, twelve weeks of a broccoli sprout beverage raise urinary excretion of benzene derivatives by 61%, and a second trial establishes the dose-response relationship.
0 to 20 mg
Tap to closeSulforaphane
Sulfodyne® is a broccoli seed extract (Brassica oleracea var. italica) patented by Ingood by Olga, standardized for free, stabilized sulforaphane. Most broccoli extracts supply glucoraphanin, an inactive precursor that gut flora must hydrolyse to release sulforaphane, a conversion that depends on the microbiome and on gastric acidity. A patented stabilization process delivers the isothiocyanate directly in its active form, with no intermediate enzymatic step. European seed origin, manufactured in France.
Sulphur-containing isothiocyanate from cruciferous vegetables, concentrated in broccoli seeds and young sprouts, where the content of glucoraphanin — its precursor — is ten to one hundred times that of mature broccoli. Sulforaphane is formed by the action of the enzyme myrosinase on glucoraphanin during chewing or processing; the selected extract already supplies it in its free form, without that step. With over three thousand publications, it is one of the most studied plant compounds of the decade. In the laboratory, it triggers a cellular defence programme: a brief molecular stress that sets off the reading of several hundred protective genes, including those of the enzymes that neutralise and clear unwanted compounds. In humans, what is measured lies downstream: in 291 adults exposed to air pollution, twelve weeks of a broccoli sprout beverage raise urinary excretion of benzene derivatives by 61%, and a second trial establishes the dose-response relationship.
0 to 20 mg
Taurine
Synthetic taurine suitable for vegetarian diets, a non-proteinogenic sulphur amino acid. Unlike the 20 protein amino acids, taurine is not incorporated into proteins: it remains free in tissues. It naturally concentrates in the heart, brain, retina and skeletal muscles. The body synthesises it from cysteine, and its dietary sources are almost exclusively animal. Obtained by chemical synthesis without animal-derived raw materials, it is chemically identical to natural taurine. Supplier-declared vegetarian suitability.
Often mistaken for a stimulant because of its presence in energy drinks, taurine is in fact a sulfur amino acid that acts as an inhibitory neuromodulator in the central nervous system. It is one of the most abundant free amino acids in the human body, concentrated in organs with high metabolic demand: heart, brain, retina and skeletal muscle. Its place in the formula rests on a cardiometabolic base: a synthesis of 34 randomized trials measures reductions in blood pressure, total cholesterol, triglycerides and insulin resistance, within a window of 1.5 to 3 g per day. The most rigorous trial in that body of work followed 120 prehypertensive adults for 12 weeks. These three axes, blood pressure, blood lipids and blood glucose, are precisely the ones that drift over the decades. Synthesized in the body from cysteine, taurine also works in complementarity with NAC, likewise present in the formula, which supplies that precursor.
0 to 3 g
Tap to closeTaurine
Synthetic taurine suitable for vegetarian diets, a non-proteinogenic sulphur amino acid. Unlike the 20 protein amino acids, taurine is not incorporated into proteins: it remains free in tissues. It naturally concentrates in the heart, brain, retina and skeletal muscles. The body synthesises it from cysteine, and its dietary sources are almost exclusively animal. Obtained by chemical synthesis without animal-derived raw materials, it is chemically identical to natural taurine. Supplier-declared vegetarian suitability.
Often mistaken for a stimulant because of its presence in energy drinks, taurine is in fact a sulfur amino acid that acts as an inhibitory neuromodulator in the central nervous system. It is one of the most abundant free amino acids in the human body, concentrated in organs with high metabolic demand: heart, brain, retina and skeletal muscle. Its place in the formula rests on a cardiometabolic base: a synthesis of 34 randomized trials measures reductions in blood pressure, total cholesterol, triglycerides and insulin resistance, within a window of 1.5 to 3 g per day. The most rigorous trial in that body of work followed 120 prehypertensive adults for 12 weeks. These three axes, blood pressure, blood lipids and blood glucose, are precisely the ones that drift over the decades. Synthesized in the body from cysteine, taurine also works in complementarity with NAC, likewise present in the formula, which supplies that precursor.
0 to 3 g
Vitamin B12
Vitamin B12 as methylcobalamin, one of the two coenzyme forms found in human physiology. Cyanocobalamin, the most widespread synthetic form on the market, occurs in human tissues only in trace amounts. Methylcobalamin takes part in the methionine cycle and homocysteine metabolism. Vitamin B12 contributes to normal energy-yielding metabolism, normal red blood cell formation and normal functioning of the nervous system.
Vitamin B12 contributes to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal homocysteine metabolism, to normal psychological function, to normal red blood cell formation, to the normal function of the immune system and to the reduction of tiredness and fatigue. It also has a role in the process of cell division. A unique vitamin among all: it contains cobalt in its corrin ring, is exclusively synthesized by microorganisms, and its absorption requires a complex mechanism involving gastric intrinsic factor. The prevalence of B12 insufficiency increases significantly with age, affecting up to 20% of people over 60, due to the progressive decrease in gastric acid and intrinsic factor production. Vegan diets imperatively require supplementation. In the formula, B12 takes part in the methylation cycle alongside vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), together ensuring efficient remethylation of homocysteine to methionine. The methylcobalamin form selected is one of the two active coenzyme forms of B12, the one that operates in the cell cytoplasm. This choice sets aside cyanocobalamin. At high doses, that form has been associated with a faster decline in renal function in people whose function is already impaired.
0 to 1,000 µg
Tap to closeVitamin B12
Vitamin B12 as methylcobalamin, one of the two coenzyme forms found in human physiology. Cyanocobalamin, the most widespread synthetic form on the market, occurs in human tissues only in trace amounts. Methylcobalamin takes part in the methionine cycle and homocysteine metabolism. Vitamin B12 contributes to normal energy-yielding metabolism, normal red blood cell formation and normal functioning of the nervous system.
Vitamin B12 contributes to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal homocysteine metabolism, to normal psychological function, to normal red blood cell formation, to the normal function of the immune system and to the reduction of tiredness and fatigue. It also has a role in the process of cell division. A unique vitamin among all: it contains cobalt in its corrin ring, is exclusively synthesized by microorganisms, and its absorption requires a complex mechanism involving gastric intrinsic factor. The prevalence of B12 insufficiency increases significantly with age, affecting up to 20% of people over 60, due to the progressive decrease in gastric acid and intrinsic factor production. Vegan diets imperatively require supplementation. In the formula, B12 takes part in the methylation cycle alongside vitamin B9 (5-MTHF) and vitamin B6 (P-5-P), together ensuring efficient remethylation of homocysteine to methionine. The methylcobalamin form selected is one of the two active coenzyme forms of B12, the one that operates in the cell cytoplasm. This choice sets aside cyanocobalamin. At high doses, that form has been associated with a faster decline in renal function in people whose function is already impaired.
0 to 1,000 µg
Vitamin B6 (P5P)
Active form of vitamin B6: pyridoxal-5-phosphate (P5P) monohydrate, diluted on maltodextrin, its only declared carrier. P5P is the vitamer enzymes bind to: it serves as a coenzyme for more than 100 enzymes, particularly in amino acid metabolism and neurotransmitter synthesis. Its activation route proceeds through phosphorylation by pyridoxal kinase, without the additional oxidation step that pyridoxine requires. Vitamin B6 contributes to normal functioning of the nervous system and to the reduction of tiredness and fatigue.
Vitamin B6 contributes to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal psychological function, to the reduction of tiredness and fatigue, to normal protein and glycogen metabolism and to the regulation of hormonal activity. Cofactor of more than 100 enzymes, B6 is primarily involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA, noradrenaline) and hemoglobin synthesis. It also participates in the conversion of tryptophan to niacin (vitamin B3). In the methylation cycle, B6 is the cofactor of the transsulfuration pathway of homocysteine, complementary to the remethylation pathway dependent on vitamins B12 and B9. The P-5-P (pyridoxal-5-phosphate) form selected is the coenzyme vitamer, the one enzymes bind to. Its activation proceeds through phosphorylation by pyridoxal kinase, without the additional oxidation step that pyridoxine requires.
0 to 7 mg
Tap to closeVitamin B6 (P5P)
Active form of vitamin B6: pyridoxal-5-phosphate (P5P) monohydrate, diluted on maltodextrin, its only declared carrier. P5P is the vitamer enzymes bind to: it serves as a coenzyme for more than 100 enzymes, particularly in amino acid metabolism and neurotransmitter synthesis. Its activation route proceeds through phosphorylation by pyridoxal kinase, without the additional oxidation step that pyridoxine requires. Vitamin B6 contributes to normal functioning of the nervous system and to the reduction of tiredness and fatigue.
Vitamin B6 contributes to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal psychological function, to the reduction of tiredness and fatigue, to normal protein and glycogen metabolism and to the regulation of hormonal activity. Cofactor of more than 100 enzymes, B6 is primarily involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA, noradrenaline) and hemoglobin synthesis. It also participates in the conversion of tryptophan to niacin (vitamin B3). In the methylation cycle, B6 is the cofactor of the transsulfuration pathway of homocysteine, complementary to the remethylation pathway dependent on vitamins B12 and B9. The P-5-P (pyridoxal-5-phosphate) form selected is the coenzyme vitamer, the one enzymes bind to. Its activation proceeds through phosphorylation by pyridoxal kinase, without the additional oxidation step that pyridoxine requires.
0 to 7 mg
Vitamin B9
Vitamin B9 as calcium L-5-methyltetrahydrofolate (5-MTHF), stabilised crystalline form. 5-MTHF is the biologically active form of folate, directly usable by the body. Unlike synthetic folic acid, it requires no enzymatic reduction by MTHFR (methylenetetrahydrofolate reductase), an enzyme whose activity is reduced in a significant portion of the population due to common genetic polymorphisms. Folate contributes to maternal tissue growth during pregnancy and to the normal function of the immune system.
Folates contribute to normal blood formation, to normal homocysteine metabolism, to normal amino acid synthesis, to normal psychological function, to the normal function of the immune system, to the reduction of tiredness and fatigue, and play a role in the process of cell division. Essential for DNA synthesis and methylation, folates are particularly active in rapidly renewing tissues: bone marrow, intestinal mucosa, and during embryonic development. Synthetic folic acid must be converted to 5-MTHF by the enzyme MTHFR before it can perform its biological functions. The 5-MTHF form selected in the formula is already at the end of that conversion: it is the form in which folate circulates in human plasma, whatever form is ingested. In the methylation cycle, B9 works in synergy with vitamin B12 (methylcobalamin) and vitamin B6 (P-5-P), also present in the formula, to ensure optimal remethylation of homocysteine.
0 to 500 µg
Tap to closeVitamin B9
Vitamin B9 as calcium L-5-methyltetrahydrofolate (5-MTHF), stabilised crystalline form. 5-MTHF is the biologically active form of folate, directly usable by the body. Unlike synthetic folic acid, it requires no enzymatic reduction by MTHFR (methylenetetrahydrofolate reductase), an enzyme whose activity is reduced in a significant portion of the population due to common genetic polymorphisms. Folate contributes to maternal tissue growth during pregnancy and to the normal function of the immune system.
Folates contribute to normal blood formation, to normal homocysteine metabolism, to normal amino acid synthesis, to normal psychological function, to the normal function of the immune system, to the reduction of tiredness and fatigue, and play a role in the process of cell division. Essential for DNA synthesis and methylation, folates are particularly active in rapidly renewing tissues: bone marrow, intestinal mucosa, and during embryonic development. Synthetic folic acid must be converted to 5-MTHF by the enzyme MTHFR before it can perform its biological functions. The 5-MTHF form selected in the formula is already at the end of that conversion: it is the form in which folate circulates in human plasma, whatever form is ingested. In the methylation cycle, B9 works in synergy with vitamin B12 (methylcobalamin) and vitamin B6 (P-5-P), also present in the formula, to ensure optimal remethylation of homocysteine.
0 to 500 µg
Vitamin C
L-ascorbic acid coated with ethylcellulose, an inert food-grade polymer. This coating protects vitamin C from oxidation and moisture degradation, two major weaknesses of unprotected ascorbic acid. Applied by aqueous granulation, it is the only inactive component of the selected material. The human body does not synthesise vitamin C (unlike most mammals). It contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Vitamin C contributes to normal collagen formation for the normal function of skin, to the protection of cells from oxidative stress, to the normal function of the immune system and increases iron absorption. Humans are one of the few mammals unable to synthesize vitamin C, a genetic peculiarity resulting from the mutation of the GULO gene approximately 60 million years ago. Vitamin C is an indispensable cofactor of prolyl hydroxylases and lysyl hydroxylases, the enzymes that catalyze the hydroxylation of proline and lysine in collagen. Without these modifications, the collagen triple helix cannot form correctly. In the formula, vitamin C works in concert with type I collagen, glycine and L-lysine to support complete collagen synthesis. It also facilitates non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract, a direct synergy with the iron bisglycinate present in the formula. Vitamin C also participates in the regeneration of oxidized vitamin E and in the biosynthesis of carnitine and noradrenaline.
0 to 750 mg
Tap to closeVitamin C
L-ascorbic acid coated with ethylcellulose, an inert food-grade polymer. This coating protects vitamin C from oxidation and moisture degradation, two major weaknesses of unprotected ascorbic acid. Applied by aqueous granulation, it is the only inactive component of the selected material. The human body does not synthesise vitamin C (unlike most mammals). It contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Vitamin C contributes to normal collagen formation for the normal function of skin, to the protection of cells from oxidative stress, to the normal function of the immune system and increases iron absorption. Humans are one of the few mammals unable to synthesize vitamin C, a genetic peculiarity resulting from the mutation of the GULO gene approximately 60 million years ago. Vitamin C is an indispensable cofactor of prolyl hydroxylases and lysyl hydroxylases, the enzymes that catalyze the hydroxylation of proline and lysine in collagen. Without these modifications, the collagen triple helix cannot form correctly. In the formula, vitamin C works in concert with type I collagen, glycine and L-lysine to support complete collagen synthesis. It also facilitates non-heme iron absorption by keeping it in reduced form (Fe2+) in the intestinal tract, a direct synergy with the iron bisglycinate present in the formula. Vitamin C also participates in the regeneration of oxidized vitamin E and in the biosynthesis of carnitine and noradrenaline.
0 to 750 mg
Vitamin D3
L-VITAL® D3 PW25 Fiber is a liposomal cholecalciferol powder derived from lanolin and deposited on an insoluble plant-fibre matrix. This animal origin is not suitable for vegan diets. The finished ingredient is manufactured in France, and its matrix combines pea fibre, sunflower lecithin, inulin and coconut MCT oil. Vitamin D contributes to the maintenance of normal bones, to the normal function of the immune system and to normal absorption/utilisation of calcium and phosphorus.
Vitamin D contributes to the normal function of the immune system, to the maintenance of normal bones, normal teeth and normal muscle function, to normal blood calcium levels and to normal absorption/utilisation of calcium and phosphorus. Vitamin D3 (cholecalciferol) is the form naturally produced by human skin under the effect of UVB rays. Above the 42nd parallel, the angle of solar incidence stays too low from November to February to allow cutaneous synthesis, and that window lengthens as latitude rises: this is what researchers call 'vitamin D winter.' Vitamin D functions as a pro-hormone: once hydroxylated to calcitriol (1,25-dihydroxyvitamin D3) by the liver then the kidneys, it binds to the VDR (Vitamin D Receptor), a transcription factor expressed in many cell types, where it governs the expression of genes involved in immunity, cell differentiation and phosphocalcic metabolism. D3 is part of the formula's bone axis, where it works in synergy with vitamin K2-MK7 (which helps a protein in bone bind calcium there) and magnesium, cofactor of vitamin D hydroxylation enzymes.
0 to 70 µg
Tap to closeVitamin D3
L-VITAL® D3 PW25 Fiber is a liposomal cholecalciferol powder derived from lanolin and deposited on an insoluble plant-fibre matrix. This animal origin is not suitable for vegan diets. The finished ingredient is manufactured in France, and its matrix combines pea fibre, sunflower lecithin, inulin and coconut MCT oil. Vitamin D contributes to the maintenance of normal bones, to the normal function of the immune system and to normal absorption/utilisation of calcium and phosphorus.
Vitamin D contributes to the normal function of the immune system, to the maintenance of normal bones, normal teeth and normal muscle function, to normal blood calcium levels and to normal absorption/utilisation of calcium and phosphorus. Vitamin D3 (cholecalciferol) is the form naturally produced by human skin under the effect of UVB rays. Above the 42nd parallel, the angle of solar incidence stays too low from November to February to allow cutaneous synthesis, and that window lengthens as latitude rises: this is what researchers call 'vitamin D winter.' Vitamin D functions as a pro-hormone: once hydroxylated to calcitriol (1,25-dihydroxyvitamin D3) by the liver then the kidneys, it binds to the VDR (Vitamin D Receptor), a transcription factor expressed in many cell types, where it governs the expression of genes involved in immunity, cell differentiation and phosphocalcic metabolism. D3 is part of the formula's bone axis, where it works in synergy with vitamin K2-MK7 (which helps a protein in bone bind calcium there) and magnesium, cofactor of vitamin D hydroxylation enzymes.
0 to 70 µg
Vitamin K2-MK7
Pharmaquinone® is a synthetic vitamin K2 as all-trans MK-7, containing more than 1% vitamin K2 and carried on microcrystalline cellulose using MCT oil. This configuration is the biologically active form of MK-7. Its extended half-life, approximately 72 hours compared with a few hours for MK-4, supports stable blood levels with a single daily intake. Vitamin K contributes to the maintenance of normal bones. Vitamin K contributes to normal blood clotting.
Vitamin K contributes to the maintenance of normal bones. Vitamin K contributes to normal blood clotting. The selected menaquinone-7 (MK-7) form is produced by synthesis and has an all-trans configuration, the only one human enzymes recognise. It stands apart from other forms of vitamin K by its long plasma half-life, about 72 hours against one to two hours for K1, which gives it a prolonged presence in the circulation on a single daily intake. In the laboratory, vitamin K2 is the cofactor of the enzyme that carboxylates osteocalcin, the bone protein that binds calcium to the matrix. That step is the one supplementation shifts most reproducibly. K2-MK7 complements vitamin D3, also present in the formula, with which it shares the calcium metabolism axis. This same bone axis includes magnesium, which contributes to the maintenance of normal bones.
0 to 180 µg
Tap to closeVitamin K2-MK7
Pharmaquinone® is a synthetic vitamin K2 as all-trans MK-7, containing more than 1% vitamin K2 and carried on microcrystalline cellulose using MCT oil. This configuration is the biologically active form of MK-7. Its extended half-life, approximately 72 hours compared with a few hours for MK-4, supports stable blood levels with a single daily intake. Vitamin K contributes to the maintenance of normal bones. Vitamin K contributes to normal blood clotting.
Vitamin K contributes to the maintenance of normal bones. Vitamin K contributes to normal blood clotting. The selected menaquinone-7 (MK-7) form is produced by synthesis and has an all-trans configuration, the only one human enzymes recognise. It stands apart from other forms of vitamin K by its long plasma half-life, about 72 hours against one to two hours for K1, which gives it a prolonged presence in the circulation on a single daily intake. In the laboratory, vitamin K2 is the cofactor of the enzyme that carboxylates osteocalcin, the bone protein that binds calcium to the matrix. That step is the one supplementation shifts most reproducibly. K2-MK7 complements vitamin D3, also present in the formula, with which it shares the calcium metabolism axis. This same bone axis includes magnesium, which contributes to the maintenance of normal bones.
0 to 180 µg
Zeaxanthin
XanMax® 2505 is the carrier raw material, an extract of Tagetes erecta flowers obtained with hexane and ethanol at a 400:1 extraction ratio. Its xanthophyll crystals are formulated with dextrin, gum acacia and tocopherols, which slow oxidation of the pigment. A single weighing supplies both lutein and zeaxanthin, in the ratio set by the standardisation of the material: at least 25% lutein and 5% zeaxanthin.
Carotenoid of the xanthophyll family, an isomer of lutein from which it differs only by the position of one double bond. That structural nuance decides its destination: zeaxanthin deposits at the centre of the fovea, the area of the retina where cones are densest, while lutein occupies the periphery of the macula. Together the two form the macular pigment, and the two travel together: the same raw material supplies them in a ratio close to that of our diet. It is also the ratio administered in the reference trials, which makes their results directly readable. The density of this pigment is measured in humans without any sampling, and it rises with intake: this is the quantity on which most trials rest. The body does not synthesise zeaxanthin. Intakes recorded in European adults remain well below the doses used in trials.
0 to 4 mg
Tap to closeZeaxanthin
XanMax® 2505 is the carrier raw material, an extract of Tagetes erecta flowers obtained with hexane and ethanol at a 400:1 extraction ratio. Its xanthophyll crystals are formulated with dextrin, gum acacia and tocopherols, which slow oxidation of the pigment. A single weighing supplies both lutein and zeaxanthin, in the ratio set by the standardisation of the material: at least 25% lutein and 5% zeaxanthin.
Carotenoid of the xanthophyll family, an isomer of lutein from which it differs only by the position of one double bond. That structural nuance decides its destination: zeaxanthin deposits at the centre of the fovea, the area of the retina where cones are densest, while lutein occupies the periphery of the macula. Together the two form the macular pigment, and the two travel together: the same raw material supplies them in a ratio close to that of our diet. It is also the ratio administered in the reference trials, which makes their results directly readable. The density of this pigment is measured in humans without any sampling, and it rises with intake: this is the quantity on which most trials rest. The body does not synthesise zeaxanthin. Intakes recorded in European adults remain well below the doses used in trials.
0 to 4 mg
Zinc
PHARMAGNESIA® ZBg A is a zinc bisglycinate containing 26.8 to 34.5% zinc and no added excipient. In this complex, each zinc atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Zinc contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Zinc contributes to the normal function of the immune system, to normal DNA synthesis, to the protection of cells from oxidative stress, to the maintenance of normal vision, normal skin and normal bones. The second most abundant trace element in the body after iron, zinc has no significant storage reserve, making a regular daily intake essential. Structurally involved in over 300 enzymes and approximately 10% of all human proteins, zinc is ubiquitous in cellular biochemistry. 'Zinc fingers' are structural protein motifs that allow hundreds of transcription factors to bind to DNA and regulate gene expression. Zinc is also a structural component of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic antioxidant defense in the body. This enzyme works in tandem with copper (also present in the formula in bisglycinate form), both minerals being necessary for its catalytic activity. A zinc-copper-iron balance is maintained in the formula to optimize absorption without excessive competition between these minerals. The dose is calibrated on serum zinc and on the copper to zinc ratio, two markers re-read at every blood panel.
0 to 15 mg
Tap to closeZinc
PHARMAGNESIA® ZBg A is a zinc bisglycinate containing 26.8 to 34.5% zinc and no added excipient. In this complex, each zinc atom is bonded to two glycine molecules, the smallest amino acid naturally present in the body. Zinc contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
Zinc contributes to the normal function of the immune system, to normal DNA synthesis, to the protection of cells from oxidative stress, to the maintenance of normal vision, normal skin and normal bones. The second most abundant trace element in the body after iron, zinc has no significant storage reserve, making a regular daily intake essential. Structurally involved in over 300 enzymes and approximately 10% of all human proteins, zinc is ubiquitous in cellular biochemistry. 'Zinc fingers' are structural protein motifs that allow hundreds of transcription factors to bind to DNA and regulate gene expression. Zinc is also a structural component of copper-zinc superoxide dismutase (Cu/Zn-SOD), one of the first lines of enzymatic antioxidant defense in the body. This enzyme works in tandem with copper (also present in the formula in bisglycinate form), both minerals being necessary for its catalytic activity. A zinc-copper-iron balance is maintained in the formula to optimize absorption without excessive competition between these minerals. The dose is calibrated on serum zinc and on the copper to zinc ratio, two markers re-read at every blood panel.
0 to 15 mg
Quality and traceability
Each bioactive is selected according to strict criteria of quality, purity and bioavailability.
Premium sources
Qualified supplier-product combinations
FR manufacturing
In-house lab in France
Eco-responsible
Recyclable packaging
Methodology
Our bioactive selection is based on the most robust longevity studies, reviewed by a multidisciplinary body of independent experts (doctors, pharmacists, nutritionists). Out of 127 bioactives evaluated since inception, 95 have been rejected. This rigor explains why every ingredient in your formula must justify its place, sources in hand.
Systematic review
Each bioactive is selected after analysis of meta-analyses and randomized scientific trials available on PubMed and Cochrane.
Bioavailable forms
We prioritize the most absorbable forms (citrate over oxide), whose exposure in humans is documented, and we set aside those that carry a safety signal.
Evidence-based dosages
Dosages are based on scientific studies that have demonstrated efficacy, not minimum recommended daily intakes.
Verified interactions
Each combination is verified for synergies (e.g., D3+K2) and potential interactions to avoid.
The price of precision
The standard industry optimizes cost per capsule. Singular optimizes biological benefit per milligram absorbed. For instance:
| Bioactive | Generic form | Singular form | Cost diff | Benefit |
|---|---|---|---|---|
| Magnesium | Oxide | Bisglycinate | 8-12× | Absorbed, no laxative effect |
| Vitamin B12 | Cyanocobalamin | Methylcobalamin | 5× | Non-cyano coenzyme form |
| Folate | Folic acid | Calcium L-5-MTHFPatented active | 10-15× | Active form, no reduction step |
| Curcumin | Standard extract | Meriva™ (phospholipid complex)Patented active | 6-8× | Absorbed without piperine |
| PQQ | Generic disodium salt | MGCPQQ® (fermentation)Patented active | 4-6× | Clinically studied form |
| Omega-3 | Fish oil (triglyceride or ethyl ester) | AvailOm® (lysine salt)Patented active | 3-5× | Stable; absorbed 1.6× vs triglyceride, 9.3× vs ethyl ester |
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Discover your personalized formula
Each bioactive is dosed to the milligram according to the applicable formulation rules. Your first formulation is free.