Singular and 4Health share a common ambition: formulating supplements from individual biological data. Singular uses the blood test as its primary data source and orients its bioactive selection toward longevity optimization — the 12 hallmarks of cellular aging. 4Health (formerly 4Gold) starts from DNA via a saliva test. This comparison details the differences between these two personalization approaches.
| Criterion | Singular | 4Health |
|---|---|---|
| Personalization | Blood + questionnaire Analysis of your actual blood biomarkers | DNA + blood (upload) + wearables + questionnaire Proprietary DNA saliva test, external blood panel upload |
| Product format | Single powder (mg-level dosing) One integrated formula, not separate capsules | 2 powder sachets/day (morning + evening) Liposomal microencapsulation, 2 daily servings |
| Biomarkers analyzed | 28+ biomarkers Longevity-oriented comprehensive panel analyzed by the algorithm | Variable (external upload) No blood test integrated into the service |
| Possible bioactives | 50+ bioactives Selected to target the biological hallmarks of aging | Up to 40 per formula Vitamins, minerals, and adaptogenic extracts |
| Price / month | 349 €/month Analysis + formula + delivery included | 80–100 €/month 12-month commitment for the first year (with DNA) |
| Commitment | No commitment Cancel anytime, no questions asked | 12 months (1st year) Annual commitment including the DNA test |
| Manufacturing | France (in-house laboratory) Fully vertically integrated | Belgium Belgian laboratory production |
| Certifications | ISO 22000, HDS Certified Health Data Hosting | Not disclosed in detail European standards |
| Scientific validation | Independent scientific committee Experts in longevity medicine, pharmacology, cellular biology, nutrition | Medical committee DNA and nutrigenomics focus |
| Delivery | FR, EU, UK, CH, US Free delivery included | Europe Delivery limited to mainland Europe |
4Health places DNA at the center of its personalization. The saliva test identifies genetic polymorphisms influencing nutrient metabolism. These predispositions are stable — they don't change over a lifetime. 4Health's medical committee orients formulation toward nutrigenomics.
Singular uses the blood test as its primary data source. Blood biomarkers reflect the body's current state: actual levels of vitamin D, iron, magnesium, and inflammation markers. These values evolve and allow iterative formula adjustment. Singular's scientific framework is built on the 12 hallmarks of cellular aging (López-Otín et al., Cell 2023), not solely on genetic polymorphisms. An independent scientific committee — experts in longevity medicine, clinical pharmacology, cellular biology, and functional nutrition — oversees every bioactive selection. Three criteria condition inclusion: proven efficacy through meta-analyses or randomized trials, documented superior bioavailability, and no functional redundancy.
DNA tells you what your body can do. Blood tells you what your body is doing right now. Both types of information are complementary, but blood data is immediately actionable for dosing.
4Health integrates data from 500+ connected devices (watches, sleep sensors, etc.) into its personalization algorithm. It's an ambitious multi-source approach.
Wearable data measures activity, sleep, and heart rate. This contextualizes lifestyle but doesn't measure micronutrient concentrations. A sleep sensor detects poor sleep quality, but doesn't measure magnesium or melatonin.
Singular focuses on the data most directly linked to dosing: the blood test. The health questionnaire captures lifestyle data without requiring a connected device.
4Health requires a 12-month commitment for the first year, which includes the DNA saliva test. This commitment is justified by amortizing the genetic test cost over time.
Singular operates with no commitment. Any month can be the last, with no justification or penalty. The blood test is included in each cycle — no cost amortized over time.
4Health's annual commitment represents an investment of 960 to 1,200 € for the first year. Singular's no-commitment model lets you test the service and decide based on measured results.
4Health adjusts the formula based on DNA data, uploaded blood results, and wearable data. The adjustment frequency depends on how often the user updates these sources.
The blood test at 4Health is external: the member must organize their own blood draw and upload the results. This friction reduces the effective frequency of updates. In practice, DNA (which doesn't change) remains the dominant data source.
Singular integrates the blood test into the service. The partner laboratory is organized, results are analyzed automatically, and the formula is recalculated. Dynamic data — the blood — effectively drives the formula.
Join the waitlist to discover your personalized formula.