Blueprint sells supplements from Bryan Johnson's anti-aging protocol. Singular formulates a unique powder calibrated to your blood biomarkers, with a longevity focus guided by an independent scientific committee. On one side, a standardized protocol built around one person. On the other, an individualized formulation built around your biology.
| Criterion | Singular | Blueprint |
|---|---|---|
| Personalization | Blood + questionnaire Analysis of your actual blood biomarkers | Online quiz Recommends fixed products based on your answers |
| Product format | Single powder (mg-level dosing) One integrated formula, not separate capsules | Separate products (capsules, powders, bars) Build-your-own stack, no integrated formula |
| Biomarkers analyzed | 28+ biomarkers Longevity-oriented comprehensive panel analyzed by the algorithm | 0 (for consumers) Bryan Johnson tests 100+ biomarkers, his customers do not |
| Possible bioactives | 50+ bioactives Selected to target the biological hallmarks of aging | ~40 products in catalog Supplements, nutrition, skincare, haircare |
| Price / month | 349 €/month Analysis + formula + delivery included | $98–300+/month Easy Stack $98/month, full stack $200–300+ |
| Commitment | No commitment Cancel anytime, no questions asked | No commitment Subscribe & save 5%, cancel anytime |
| Manufacturing | France (in-house laboratory) Fully vertically integrated | United States COAs available, no published ISO certification |
| Certifications | ISO 22000, HDS Certified Health Data Hosting | COA (Certificates of Analysis) No published ISO or GMP certification |
| Scientific validation | Independent scientific committee Experts in longevity medicine, pharmacology, cellular biology, nutrition | Bryan Johnson's personal protocol Based on published research, no independent scientific committee |
| Delivery | FR, EU, UK, CH, US Free delivery included | United States primarily Limited international shipping |
Blueprint is built on Bryan Johnson's anti-aging protocol — an entrepreneur who invests roughly $2 million per year in his personal longevity. The consumer products are simplified, accessible versions of that protocol.
The fundamental problem: one person's protocol is not transferable to every biology. Bryan Johnson tests over 100 biomarkers to calibrate his own regimen. His customers receive an online quiz.
Singular resolves this asymmetry. Every member has their own blood panel, analyzed by an algorithm that explores over one billion combinations. The formula is governed by an independent scientific committee composed of experts in longevity medicine, clinical pharmacology, cellular biology, and functional nutrition.
Blueprint sells individual products that consumers assemble into a stack. Longevity Mix, Essential Capsules, Omega-3, NAC+Ginger+Curcumin — each product is formulated independently. Nutrient interactions are not optimized at the system level.
Singular manufactures a single powder formula where every bioactive is dosed to the milligram. Synergies (magnesium + vitamin B6) and antagonisms (calcium vs iron) are built into the design. The result is one daily serving, not a stack of capsules.
Every Singular bioactive must clear three barriers before inclusion: efficacy evidence from meta-analyses or randomized controlled trials, demonstrated superior bioavailability, and no functional redundancy. Of 127 bioactives evaluated, 74 were rejected.
The Blueprint Easy Stack (Longevity Mix + Essential Capsules) costs $98 per month. A more complete stack with Omega-3, NAC+Ginger+Curcumin, Creatine, and Collagen Peptides approaches $250 to $300 per month. Over 12 months: $1,176 to $3,600.
Singular costs €349 per month, all inclusive: blood panel, algorithmic analysis of 28+ biomarkers, unit manufacturing in an integrated French laboratory (ISO 22000, HDS), and free delivery. Over 12 months: €4,188.
The price gap reflects the difference between buying standardized products and receiving a formula manufactured for your biology. Blueprint offers neither blood analysis nor individualized manufacturing.
Bryan Johnson has built a massive following around his quest for biological rejuvenation. His transparency about his personal protocol is a powerful marketing asset. But one individual's notoriety does not replace the rigor of a structured scientific process.
Blueprint has no published independent scientific committee. Formulations are based on published research interpreted by an internal team. The commercial protocol is a simplified version of Bryan Johnson's personal regimen.
Singular relies on an independent college of experts (longevity medicine, clinical pharmacology, cellular biology, functional nutrition) whose work shapes every formula. The scientific framework is grounded in the 12 hallmarks of cellular aging (López-Otín et al., Cell 2023).
Join the waitlist to discover your personalized formula.