Singular vs NOVOS: complete 2026 comparison

Q: Does NOVOS offer a blood test to personalize the formula?

No. NOVOS sells an epigenetic biological age test (NOVOS Age, $299, US only) that measures your biological age but does not change the composition of the supplements. Every NOVOS product — Core, Boost, Vital — is a fixed formula identical for all buyers.

Q: Do NOVOS clinical trials apply to me individually?

Clinical trials measure an average effect on a population. A participant with vitamin D deficiency benefits from high-dose supplementation; another with optimal levels does not. The average obscures this heterogeneity. Biomarker personalization does not replace clinical trials — it applies their conclusions to your specific biology.

Q: What is the difference between the NOVOS stack and a Singular formula?

NOVOS recommends 3 to 4 separate products (Core + Boost + Vital, optionally Bar) to cover different axes. Singular integrates every necessary bioactive into one powder formula, dosed to the milligram based on your blood panel. The architectural difference — assembling fixed products vs unit-manufactured calibrated formulation — defines the level of precision that can be reached.

Q: Can you combine Singular and NOVOS?

It is not recommended. Singular already integrates every bioactive needed based on your biomarkers. Adding NOVOS Core or Boost would create duplication (Ca-AKG, NR, etc. already present in Singular when indicated) and overdose risk for certain nutrients.

Q: Is the NOVOS biological age test useful?

Epigenetic biological age tests measure a global aging indicator, useful for tracking evolution over time. They do not replace functional analysis of actionable biomarkers (ferritin, vitamin D, HbA1c, hs-CRP, etc.) that guides formulation. NOVOS Age is sold separately and is only available in the United States.

NOVOS and Singular share the same scientific framework — the 12 hallmarks of cellular aging — but apply it in fundamentally different ways. NOVOS sells a standardized longevity stack (Core + Boost + Vital, with a biological age test sold separately), a fixed formula identical for everyone. Singular formulates a unique powder calibrated to 28+ individual blood biomarkers, governed by an independent scientific committee.

Detailed comparison

Criterion	Singular	NOVOS
Personalization	Blood + questionnaire Analysis of your actual blood biomarkers	None Fixed formula identical for all users
Product format	Single powder (mg-level dosing) One integrated formula, not separate capsules	Multi-product stack Core + Boost + Vital + bars + separate Age test
Biomarkers analyzed	28+ biomarkers Longevity-oriented comprehensive panel analyzed by the algorithm	0 (for formula calibration) Age test sold separately, not used to personalize
Possible bioactives	44+ bioactives Selected to target the biological hallmarks of aging	12 ingredients (NOVOS Core) + add-ons Ca-AKG, Fisetin, Pterostilbene, Lithium, Rhodiola, etc.
Price / month	349 €/month Analysis + formula + delivery included	~$160/month (full stack) Core $79 + Boost $32 + Vital $49 · Age test $299/year
Commitment	No commitment Cancel anytime, no questions asked	No commitment Cancel anytime subscription
Manufacturing	France (in-house laboratory) Fully vertically integrated	United States (cGMP) Third-party tested, COAs available
Certifications	ISO 22000, HDS Certified Health Data Hosting	cGMP, third-party tested No published ISO 22000 or HDS certification
Scientific validation	Independent scientific committee Experts in longevity medicine, pharmacology, cellular biology, nutrition	Harvard & MIT scientists, clinical trials Published randomized controlled trials on the fixed formula
Delivery	FR, EU, UK, CH, US Free delivery included	International Age test US only

Analysis

Shared scientific framework, diverging approaches: what does it mean?

NOVOS and Singular both build on the 12 hallmarks of cellular aging (López-Otín et al., Cell 2023). This framework identifies the biological mechanisms that govern the pace of aging — genomic instability, telomere attrition, chronic inflammation, cellular senescence, and more. But the framework does not prescribe uniformity: each hallmark manifests differently depending on individual biology.

NOVOS applies population averages to a fixed formula. Every buyer receives the same dose of Ca-AKG, Fisetin, and Pterostilbene, regardless of age, sex, inflammation level, or nutritional status. Singular applies individual blood biomarkers to a calibrated formula: every bioactive (presence, dose, form) is adjusted based on your panel.

At Singular, formulation is governed by an independent scientific committee composed of experts in longevity medicine, clinical pharmacology, cellular biology, and functional nutrition. Every bioactive must clear three barriers before inclusion: efficacy evidence from meta-analyses or randomized controlled trials, demonstrated superior bioavailability, and no functional redundancy. Of 127 bioactives evaluated, 74 were rejected.

Fixed formula or calibrated formula: what is the real difference?

NOVOS Core contains 12 ingredients at identical doses for every customer — the same Ca-AKG dose, the same Fisetin dose, the same Pterostilbene dose, whether the customer is 30 or 70, whether inflammation is high or low, whether vitamin D status is optimal or deficient. The NOVOS Age biological age test, sold separately, measures epigenetic age but does not change the composition of the supplements shipped.

Singular adjusts each bioactive — dose, presence or absence, form — based on the member's blood biomarkers. A user with elevated hs-CRP and optimal ferritin does not receive the same formula as a user with borderline HbA1c and low vitamin D.

The Singular algorithm explores over one billion combinations across 50+ bioactives drawn from an evidence-curated library. Every component is dosed to the milligram based on your panel. The difference is not cosmetic: two different biologies call for two different formulas.

Do clinical trials on a fixed formula prove individual efficacy for you?

NOVOS has published randomized double-blind placebo-controlled trials — genuinely rare and commendable in the supplement industry. Preclinical mouse studies report roughly 18% lifespan extension. This work deserves credit.

But a clinical trial measures the average effect of a formula on a population. A participant with vitamin D deficiency benefits from high-dose supplementation; a participant with optimal levels does not — and may face overdose risk. The average obscures this individual heterogeneity. For a consumer, the relevant question is not "did this formula work on average?" but "is this formula right for my specific biology?"

Biomarker personalization does not replace clinical science — it applies it correctly to the individual. Every bioactive in the Singular library must itself clear the three barriers (meta-analyses, randomized controlled trials, superior bioavailability, no functional redundancy). Clinical rigor adds to individual calibration.

Multi-product stack or integrated formula: what is the true 12-month cost?

The full NOVOS stack — Core ($79) + Boost ($32) + Vital ($49) — comes to about $160 per month. Adding the NOVOS Age biological age test ($299/year, United States only) brings the annual total to roughly $2,219 for a US customer, or $1,920 internationally (without the Age test). This stack requires taking 3 to 4 separate products daily.

Singular costs €349 per month, all inclusive: blood panel, algorithmic analysis of 28+ biomarkers, unit manufacturing in an integrated French laboratory (ISO 22000 and HDS certifications), and free delivery. Over 12 months: €4,188. One daily serving, not a stack of products.

The price gap reflects the method: buying a standardized product line, or receiving a formula manufactured for your biology and recalibrated every three months based on new blood panels. These are not two prices for the same service: they are two different services.

Who is it for?

Singular is right for you if

✓You want a formula calibrated to your own blood biomarkers;
✓Quarterly adjustment of your formula based on how your markers evolve matters to you;
✓You prefer one daily serving rather than a stack of 3 to 4 products;
✓You are looking for an integrated laboratory with ISO 22000 and HDS certifications.

NOVOS is right for you if

•You align with NOVOS's longevity philosophy and scientific approach;
•You prefer a product backed by published clinical trials on the fixed formula;
•You are looking for a lower entry price ($79/month for Core alone);
•A separate biological age test (NOVOS Age) fits your self-measurement approach.

Frequently asked questions

Does NOVOS offer a blood test to personalize the formula?#[ + ]

Do NOVOS clinical trials apply to me individually?#[ + ]

What is the difference between the NOVOS stack and a Singular formula?#[ + ]

Can you combine Singular and NOVOS?#[ + ]

Is the NOVOS biological age test useful?#[ + ]

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