Rootine no longer offers personalized supplements based on blood or DNA. After its acquisition by Rhodium Software in February 2025, the service pivoted to standardized functional beverages (Stress, Sleep, Focus). This comparison documents the current situation and differences from the Singular approach, whose biomarker and bioactive selection specifically targets the hallmarks of cellular aging.
| Criterion | Singular | Rootine |
|---|---|---|
| Personalization | Blood + questionnaire Analysis of your actual blood biomarkers | None (since 2025) Formerly: blood + DNA. Now: standardized products |
| Product format | Single powder (mg-level dosing) One integrated formula, not separate capsules | Powder sachets (functional beverages) Standardized beverages: Stress, Sleep, Focus |
| Biomarkers analyzed | 28+ biomarkers Longevity-oriented comprehensive panel analyzed by the algorithm | 0 No blood analysis since the 2025 pivot |
| Possible bioactives | 50+ bioactives Selected to target the biological hallmarks of aging | Fixed formulas Identical composition for all buyers |
| Price / month | 349 €/month Analysis + formula + delivery included | $25–45/sachet Sold individually or in packs |
| Commitment | No commitment Cancel anytime, no questions asked | None One-time purchase or subscription |
| Manufacturing | France (in-house laboratory) Fully vertically integrated | United States Standardized production |
| Certifications | ISO 22000, HDS Certified Health Data Hosting | Not disclosed Information not publicly available |
| Scientific validation | Independent scientific committee Experts in longevity medicine, pharmacology, cellular biology, nutrition | N/A (2025 pivot) No scientific personalization since the pivot |
| Delivery | FR, EU, UK, CH, US Free delivery included | United States only No international delivery |
No. Since the 2025 pivot, Rootine has abandoned its blood and DNA personalization model. The legacy service — micro-doses of vitamins calibrated from a blood panel and DNA test — no longer exists.
Rootine now sells functional powder beverages in three standardized formulas: Stress, Sleep, and Focus. The composition is identical for all buyers. This is no longer personalized supplementation.
For former Rootine users seeking a blood-based personalized alternative, the market has changed significantly since 2025.
Rootine, based in Nashville, Tennessee, was acquired by Rhodium Software in February 2025. Following this acquisition, the business model was completely overhauled.
The blood biomarker and DNA personalization service was discontinued. The patented micro-beads (slow-release micro-spheres) are no longer produced. The website no longer mentions blood analysis or individual personalization.
This pivot illustrates the fragility of advanced personalization services when the business model fails to achieve financial sustainability.
Former Rootine users had access to a service combining DNA analysis and blood biomarkers. This positioning has no exact equivalent on today's market.
Singular offers blood-based personalization (28+ biomarkers) with individual manufacturing in a French laboratory. The format is a precision powder, dosed to the milligram. Delivery covers Europe, the United Kingdom, Switzerland, and the United States. Unlike Rootine, which assembled standardized micro-beads, Singular subjects every bioactive to a rigorous selection process overseen by an independent scientific committee (longevity medicine, pharmacology, cellular biology, nutrition). Three barriers condition inclusion: proven efficacy through meta-analyses or randomized controlled trials, superior bioavailability form, and no functional redundancy. Of 127 bioactives evaluated, 74 were rejected. The scientific framework is built on the 12 hallmarks of cellular aging (López-Otín et al., Cell 2023), positioning Singular as the longevity-focused alternative for those who sought more than simple deficit correction.
The key difference: Rootine integrated DNA data into its personalization. Singular focuses on blood biomarkers, whose variability is measurable and actionable at each cycle.
DNA is stable: it doesn't change over a lifetime. Blood biomarkers vary based on diet, lifestyle, seasons, and stress levels. This variability is precisely what makes them actionable.
A DNA test identifies predispositions (e.g., slow vitamin D metabolism, risk of folate deficiency). But it doesn't measure current status. A blood test says: "Today, your vitamin D is at 18 ng/mL."
Singular prioritizes dynamic data — the blood test — because it enables iterative formula adjustment at each cycle. DNA provides the context. Blood provides the direction.
Join the waitlist to discover your personalized formula.