Precision Supplementation
Supplementation is a complex science that requires precision, quality, and personalization. What works for one person may be ineffective or toxic for another.
Bioactive taxonomy
Not all supplements are created equal. We must distinguish survival from optimization.
Essentials (nutritional needs)
Vitamins and minerals to compensate for modern deficits. Depleted soils, industrial food, and sedentary lifestyles create near-universal nutritional needs.
Geroprotectors (longevity)
Molecules that the body doesn't produce or no longer produces enough of, acting on the fundamental mechanisms of cellular aging.
The universal formula myth
The average doesn't exist. What suits one person may not suit another. Your biology is unique — your supplementation must be too.
The U-Curve (hormesis)
Too little is bad, too much is toxic. Only a blood test defines your position on the curve.
Example: vitamin D
Two people taking 2000 IU will have radically different blood levels depending on their genetics (vitamin D receptor), body fat (D3 is fat-soluble), and sun exposure.
Variability factors: VDR genetics, body fat, skin pigmentation, latitude, season.
Scientific evidence: N=1
The Cell study (2015) on personalized glycemic response demonstrated that two people eating the same food can have radically different metabolic responses. Biology is unique. (lien)
Supplementation During Pregnancy
Avoid during pregnancy
Consider adding during pregnancy
- Methylated folate: 600 mcg/day (not synthetic folic acid)
- Vitamin B12 methylcobalamin: 2.5 mcg/day
- Magnesium: 500-600 mg/day
- Iron: 30 mg/day
- Calcium: 1200 mg/day
- DHA/EPA: 1000-2000 mg/day (low heavy metal source)
Consult your doctor before any supplementation during pregnancy.
Possible Luteal Phase Adjustments
- Magnesium: +100-200 mg/day (mood, cramps)
- Sodium: +200-400 mg/day (water retention)
- Potassium: +200-400 mg/day (water retention)
- Ashwagandha: 300-600 mg/day (stress, PMS)
- Rhodiola Rosea: 200-400 mg/day (fatigue, mood)
- Melatonin: 1-3 mg if sleep issues
Interaction chemistry
The stomach is a chemical reactor. Random mixing creates conflicts. The importance of precise timing and ratios is critical.
Antagonisms
Zinc and copper use the same intestinal transporter (MT1). Excess zinc blocks copper absorption. Dosages should therefore be dynamically adjusted based on your blood tests to maintain an optimal ratio. (lien)
An imbalanced ratio creates secondary imbalances.
Synergies
Vitamin D3 + K2
Vitamin D increases calcium absorption, but without vitamin K2, this calcium calcifies arteries instead of strengthening bones. K2 directs calcium to the bones.
Purity & bioavailability
What's written on the label isn't what reaches your cells. The chemical form determines actual absorption.
The forms deception: magnesium
Why does the industry use oxide? Because it costs 10x less. (lien)
To avoid (industry)
- Titanium dioxide (E171)
- Excessive magnesium stearate
- Talc (E553b)
- Artificial colorings
Ideal standard
- 100% active, 0% filler
- Patented high-absorption forms
- Third-party testing (heavy metals, contaminants)
- Transparent certifications
The feedback loop
A formula is never final. Your needs change, science advances. A static approach quickly becomes obsolete.
Biological adaptation
Your needs constantly evolve. What worked 6 months ago may no longer be optimal today.
Scientific obsolescence
Longevity science advances rapidly. Example: the recent questioning of Resveratrol. What was recommended yesterday may be outdated tomorrow.