Longevity Watch
Advances in global aging research: clinical studies, measurement technologies, biotech.
The Centenarian Microbiome: What Three Bacteria Reveal About Aging
Akkermansia, Bacillus subtilis, Bifidobacterium longum: three microbial signatures associated with longevity. Decoding the mechanisms and the probiotic vs postbiotic distinction.
Sun Exposure and Longevity: The Paradox Dermatology Refuses to See
Large epidemiological cohorts converge: total sun avoidance is a mortality risk factor comparable to smoking. Mechanisms, data, and the optimal exposure window.
Psychedelics and Neuroplasticity: When Science Separates the Trip from the Therapeutic Effect
Psilocybin, ketamine, LSD, DMT: psychedelics restart synaptogenesis through now-identified mechanisms. Non-hallucinogenic analogues open an unprecedented path for brain aging.
Antibiotics and the Microbiome: An Eight-Year Scar
A Nature Medicine study of nearly 15,000 adults reveals that certain antibiotics reduce gut diversity for up to eight years. A data-driven analysis of the findings and their implications.
Longevity diets: what epidemiological data actually shows
Blue Zones, Mediterranean diet, Okinawa: a critical analysis of the methodological biases in population studies on diet and longevity. What remains when survivor bias is removed?
ER-100: The First Partial Epigenetic Reprogramming Therapy to Reach a Human Clinical Trial
Life Biosciences received FDA clearance to test ER-100, an OSK gene therapy for cellular rejuvenation, in patients with optic neuropathies. A comprehensive analysis.
Gene therapy and longevity: from follistatin to genome editing
From AAV vectors to CRISPR, gene therapy now targets aging itself. Follistatin, telomerase, klotho, APOE: a rigorous scientific assessment of where we stand.
Mesenchymal Stem Cells: Promises and Realities of Regenerative Medicine
MSCs fascinate with their differentiation capacity and paracrine activity. From clinical trials to commercial clinics and cell-free therapies, a rigorous assessment.
Longevity Pharmacology: The Molecules Under Scientific Surveillance
A critical overview of pharmaceutical molecules studied for their potential impact on human longevity. Animal data, clinical trials, mechanisms, and limitations.
The mTOR Pathway: The Precarious Balance Between Cell Growth and Longevity
mTOR is the central kinase regulating growth, protein synthesis, and autophagy. Longevity science reveals a fundamental paradox: what drives growth in youth accelerates aging. A scientific breakdown.
Bioactive Peptides: Between Laboratory Promises and Clinical Reality
BPC-157, TB-500, GHK-Cu, Epithalon, MOTS-c: a scientific review of the peptides championed by the longevity community. Evidence levels, animal vs human data, real risks.
Heterochronic Parabiosis: Can Young Blood Reverse Aging
From parabiosis experiments to young plasma clinics, science explores blood-borne aging factors. A rigorous assessment of promises, controversies, and evidence.
Blood Donation: An Unexpected Lever for Longevity
Regular iron depletion through blood donation reduces oxidative stress, improves insulin sensitivity, and stimulates haematopoietic renewal. Epidemiological data and mechanisms.
Cellular Senescence: When Your Cells Refuse to Die
Senescent cells accumulate with age and secrete an inflammatory cocktail (SASP) that accelerates tissue aging. Mechanisms, biomarkers, and senolytic leads under investigation.
Epigenetic Clock: Your Biological Age Is Not Your Chronological Age
DNA methylation enables biological age measurement with 2 to 3 years precision. The Horvath and GrimAge clocks open the path to longitudinal monitoring of aging trajectories.
Medicine 3.0: The Transition from Clinical Intervention to Proactive Optimization
Waiting for biomarkers to turn red before intervening is a strategy built for emergencies, not chronic prevention. A different medical logic is emerging.